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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PBX2
Full Name:
Pre-B-cell leukemia transcription factor 2
Alias:
G17; G17 protein; Homeobox 12; Homeobox protein PBX2; HOX12; PBX2MHC; Pre-B-cell leukemia homeobox 2
Type:
Transcription protein
Mass (Da):
45881
Number AA:
430
UniProt ID:
P40425
International Prot ID:
IPI00028416
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
R
G
G
L
G
L
V
S
G
E
P
G
G
P
G
Site 2
S41
G
G
D
P
G
G
G
S
G
G
V
P
G
G
R
Site 3
T62
D
I
L
Q
Q
I
M
T
I
T
D
Q
S
L
D
Site 4
S101
I
K
E
K
T
G
L
S
I
R
S
S
Q
E
E
Site 5
S104
K
T
G
L
S
I
R
S
S
Q
E
E
E
P
V
Site 6
S105
T
G
L
S
I
R
S
S
Q
E
E
E
P
V
D
Site 7
S136
G
P
E
K
G
G
G
S
A
A
A
A
A
A
A
Site 8
S151
A
A
S
G
G
G
V
S
P
D
N
S
I
E
H
Site 9
S155
G
G
V
S
P
D
N
S
I
E
H
S
D
Y
R
Site 10
S159
P
D
N
S
I
E
H
S
D
Y
R
S
K
L
A
Site 11
Y161
N
S
I
E
H
S
D
Y
R
S
K
L
A
Q
I
Site 12
S163
I
E
H
S
D
Y
R
S
K
L
A
Q
I
R
H
Site 13
Y172
L
A
Q
I
R
H
I
Y
H
S
E
L
E
K
Y
Site 14
S174
Q
I
R
H
I
Y
H
S
E
L
E
K
Y
E
Q
Site 15
Y179
Y
H
S
E
L
E
K
Y
E
Q
A
C
N
E
F
Site 16
S198
M
N
L
L
R
E
Q
S
R
T
R
P
V
A
P
Site 17
T200
L
L
R
E
Q
S
R
T
R
P
V
A
P
K
E
Site 18
S213
K
E
M
E
R
M
V
S
I
I
H
R
K
F
S
Site 19
S220
S
I
I
H
R
K
F
S
A
I
Q
M
Q
L
K
Site 20
S252
R
R
K
R
R
N
F
S
K
Q
A
T
E
V
L
Site 21
T256
R
N
F
S
K
Q
A
T
E
V
L
N
E
Y
F
Site 22
Y262
A
T
E
V
L
N
E
Y
F
Y
S
H
L
S
N
Site 23
Y264
E
V
L
N
E
Y
F
Y
S
H
L
S
N
P
Y
Site 24
S268
E
Y
F
Y
S
H
L
S
N
P
Y
P
S
E
E
Site 25
Y271
Y
S
H
L
S
N
P
Y
P
S
E
E
A
K
E
Site 26
Y302
F
G
N
K
R
I
R
Y
K
K
N
I
G
K
F
Site 27
Y316
F
Q
E
E
A
N
I
Y
A
V
K
T
A
V
S
Site 28
S323
Y
A
V
K
T
A
V
S
V
T
Q
G
G
H
S
Site 29
T325
V
K
T
A
V
S
V
T
Q
G
G
H
S
R
T
Site 30
S330
S
V
T
Q
G
G
H
S
R
T
S
S
P
T
P
Site 31
T332
T
Q
G
G
H
S
R
T
S
S
P
T
P
P
S
Site 32
S333
Q
G
G
H
S
R
T
S
S
P
T
P
P
S
S
Site 33
S334
G
G
H
S
R
T
S
S
P
T
P
P
S
S
A
Site 34
T336
H
S
R
T
S
S
P
T
P
P
S
S
A
G
S
Site 35
S339
T
S
S
P
T
P
P
S
S
A
G
S
G
G
S
Site 36
S340
S
S
P
T
P
P
S
S
A
G
S
G
G
S
F
Site 37
S343
T
P
P
S
S
A
G
S
G
G
S
F
N
L
S
Site 38
S346
S
S
A
G
S
G
G
S
F
N
L
S
G
S
G
Site 39
S350
S
G
G
S
F
N
L
S
G
S
G
D
M
F
L
Site 40
S366
M
P
G
L
N
G
D
S
Y
S
A
S
Q
V
E
Site 41
Y367
P
G
L
N
G
D
S
Y
S
A
S
Q
V
E
S
Site 42
S368
G
L
N
G
D
S
Y
S
A
S
Q
V
E
S
L
Site 43
S370
N
G
D
S
Y
S
A
S
Q
V
E
S
L
R
H
Site 44
S374
Y
S
A
S
Q
V
E
S
L
R
H
S
M
G
P
Site 45
S378
Q
V
E
S
L
R
H
S
M
G
P
G
G
Y
G
Site 46
Y384
H
S
M
G
P
G
G
Y
G
D
N
L
G
G
G
Site 47
S395
L
G
G
G
Q
M
Y
S
P
R
E
M
R
A
N
Site 48
T410
G
S
W
Q
E
A
V
T
P
S
S
V
T
S
P
Site 49
S412
W
Q
E
A
V
T
P
S
S
V
T
S
P
T
E
Site 50
S413
Q
E
A
V
T
P
S
S
V
T
S
P
T
E
G
Site 51
S416
V
T
P
S
S
V
T
S
P
T
E
G
P
G
S
Site 52
T418
P
S
S
V
T
S
P
T
E
G
P
G
S
V
H
Site 53
S423
S
P
T
E
G
P
G
S
V
H
S
D
T
S
N
Site 54
S426
E
G
P
G
S
V
H
S
D
T
S
N
_
_
_
Site 55
T428
P
G
S
V
H
S
D
T
S
N
_
_
_
_
_
Site 56
S429
G
S
V
H
S
D
T
S
N
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation