KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MLH1
Full Name:
DNA mismatch repair protein Mlh1
Alias:
COCA2; E.coli MutL homolog gene; FCC2; HNPCC; HNPCC2; MutL 1; MutL protein homologue 1
Type:
DNA repair protein
Mass (Da):
84601
Number AA:
756
UniProt ID:
P40692
International Prot ID:
IPI00029754
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000793
GO:0000795
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0000003
GO:0000018
GO:0000019
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T81
D
I
V
C
E
R
F
T
T
S
K
L
Q
S
F
Site 2
T82
I
V
C
E
R
F
T
T
S
K
L
Q
S
F
E
Site 3
S83
V
C
E
R
F
T
T
S
K
L
Q
S
F
E
D
Site 4
S87
F
T
T
S
K
L
Q
S
F
E
D
L
A
S
I
Site 5
S93
Q
S
F
E
D
L
A
S
I
S
T
Y
G
F
R
Site 6
T119
H
V
T
I
T
T
K
T
A
D
G
K
C
A
Y
Site 7
S129
G
K
C
A
Y
R
A
S
Y
S
D
G
K
L
K
Site 8
Y130
K
C
A
Y
R
A
S
Y
S
D
G
K
L
K
A
Site 9
S131
C
A
Y
R
A
S
Y
S
D
G
K
L
K
A
P
Site 10
T151
G
N
Q
G
T
Q
I
T
V
E
D
L
F
Y
N
Site 11
Y157
I
T
V
E
D
L
F
Y
N
I
A
T
R
R
K
Site 12
S170
R
K
A
L
K
N
P
S
E
E
Y
G
K
I
L
Site 13
Y183
I
L
E
V
V
G
R
Y
S
V
H
N
A
G
I
Site 14
S184
L
E
V
V
G
R
Y
S
V
H
N
A
G
I
S
Site 15
S191
S
V
H
N
A
G
I
S
F
S
V
K
K
Q
G
Site 16
S193
H
N
A
G
I
S
F
S
V
K
K
Q
G
E
T
Site 17
T206
E
T
V
A
D
V
R
T
L
P
N
A
S
T
V
Site 18
T237
E
I
G
C
E
D
K
T
L
A
F
K
M
N
G
Site 19
Y245
L
A
F
K
M
N
G
Y
I
S
N
A
N
Y
S
Site 20
Y251
G
Y
I
S
N
A
N
Y
S
V
K
K
C
I
F
Site 21
S269
I
N
H
R
L
V
E
S
T
S
L
R
K
A
I
Site 22
T270
N
H
R
L
V
E
S
T
S
L
R
K
A
I
E
Site 23
S271
H
R
L
V
E
S
T
S
L
R
K
A
I
E
T
Site 24
Y280
R
K
A
I
E
T
V
Y
A
A
Y
L
P
K
N
Site 25
T288
A
A
Y
L
P
K
N
T
H
P
F
L
Y
L
S
Site 26
Y293
K
N
T
H
P
F
L
Y
L
S
L
E
I
S
P
Site 27
S295
T
H
P
F
L
Y
L
S
L
E
I
S
P
Q
N
Site 28
S332
R
V
Q
Q
H
I
E
S
K
L
L
G
S
N
S
Site 29
S337
I
E
S
K
L
L
G
S
N
S
S
R
M
Y
F
Site 30
S339
S
K
L
L
G
S
N
S
S
R
M
Y
F
T
Q
Site 31
S340
K
L
L
G
S
N
S
S
R
M
Y
F
T
Q
T
Site 32
Y343
G
S
N
S
S
R
M
Y
F
T
Q
T
L
L
P
Site 33
S362
P
S
G
E
M
V
K
S
T
T
S
L
T
S
S
Site 34
T363
S
G
E
M
V
K
S
T
T
S
L
T
S
S
S
Site 35
T364
G
E
M
V
K
S
T
T
S
L
T
S
S
S
T
Site 36
S365
E
M
V
K
S
T
T
S
L
T
S
S
S
T
S
Site 37
T367
V
K
S
T
T
S
L
T
S
S
S
T
S
G
S
Site 38
S368
K
S
T
T
S
L
T
S
S
S
T
S
G
S
S
Site 39
S369
S
T
T
S
L
T
S
S
S
T
S
G
S
S
D
Site 40
S370
T
T
S
L
T
S
S
S
T
S
G
S
S
D
K
Site 41
T371
T
S
L
T
S
S
S
T
S
G
S
S
D
K
V
Site 42
S372
S
L
T
S
S
S
T
S
G
S
S
D
K
V
Y
Site 43
S374
T
S
S
S
T
S
G
S
S
D
K
V
Y
A
H
Site 44
S375
S
S
S
T
S
G
S
S
D
K
V
Y
A
H
Q
Site 45
Y379
S
G
S
S
D
K
V
Y
A
H
Q
M
V
R
T
Site 46
T386
Y
A
H
Q
M
V
R
T
D
S
R
E
Q
K
L
Site 47
S388
H
Q
M
V
R
T
D
S
R
E
Q
K
L
D
A
Site 48
S401
D
A
F
L
Q
P
L
S
K
P
L
S
S
Q
P
Site 49
S405
Q
P
L
S
K
P
L
S
S
Q
P
Q
A
I
V
Site 50
S406
P
L
S
K
P
L
S
S
Q
P
Q
A
I
V
T
Site 51
T417
A
I
V
T
E
D
K
T
D
I
S
S
G
R
A
Site 52
S421
E
D
K
T
D
I
S
S
G
R
A
R
Q
Q
D
Site 53
S446
E
V
A
A
K
N
Q
S
L
E
G
D
T
T
K
Site 54
T452
Q
S
L
E
G
D
T
T
K
G
T
S
E
M
S
Site 55
T455
E
G
D
T
T
K
G
T
S
E
M
S
E
K
R
Site 56
S459
T
K
G
T
S
E
M
S
E
K
R
G
P
T
S
Site 57
T465
M
S
E
K
R
G
P
T
S
S
N
P
R
K
R
Site 58
S466
S
E
K
R
G
P
T
S
S
N
P
R
K
R
H
Site 59
S467
E
K
R
G
P
T
S
S
N
P
R
K
R
H
R
Site 60
S477
R
K
R
H
R
E
D
S
D
V
E
M
V
E
D
Site 61
S486
V
E
M
V
E
D
D
S
R
K
E
M
T
A
A
Site 62
T495
K
E
M
T
A
A
C
T
P
R
R
R
I
I
N
Site 63
T504
R
R
R
I
I
N
L
T
S
V
L
S
L
Q
E
Site 64
S508
I
N
L
T
S
V
L
S
L
Q
E
E
I
N
E
Site 65
Y548
A
Q
H
Q
T
K
L
Y
L
L
N
T
T
K
L
Site 66
T552
T
K
L
Y
L
L
N
T
T
K
L
S
E
E
L
Site 67
S592
L
A
M
L
A
L
D
S
P
E
S
G
W
T
E
Site 68
S595
L
A
L
D
S
P
E
S
G
W
T
E
E
D
G
Site 69
T598
D
S
P
E
S
G
W
T
E
E
D
G
P
K
E
Site 70
Y610
P
K
E
G
L
A
E
Y
I
V
E
F
L
K
K
Site 71
Y625
K
A
E
M
L
A
D
Y
F
S
L
E
I
D
E
Site 72
S627
E
M
L
A
D
Y
F
S
L
E
I
D
E
E
G
Site 73
S675
E
E
K
E
C
F
E
S
L
S
K
E
C
A
M
Site 74
Y684
S
K
E
C
A
M
F
Y
S
I
R
K
Q
Y
I
Site 75
Y690
F
Y
S
I
R
K
Q
Y
I
S
E
E
S
T
L
Site 76
S692
S
I
R
K
Q
Y
I
S
E
E
S
T
L
S
G
Site 77
T696
Q
Y
I
S
E
E
S
T
L
S
G
Q
Q
S
E
Site 78
S698
I
S
E
E
S
T
L
S
G
Q
Q
S
E
V
P
Site 79
S702
S
T
L
S
G
Q
Q
S
E
V
P
G
S
I
P
Site 80
S707
Q
Q
S
E
V
P
G
S
I
P
N
S
W
K
W
Site 81
Y721
W
T
V
E
H
I
V
Y
K
A
L
R
S
H
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation