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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MDH1
Full Name:
Malate dehydrogenase, cytoplasmic
Alias:
Cytosolic malate dehydrogenase; Malate dehydrogenase 1, NAD (soluble); MDHA; MDHC; MDH-s; MOR2
Type:
Oxidoreductase; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 1.1.1.37; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - citrate (TCA) cycle
Mass (Da):
36426
Number AA:
334
UniProt ID:
P40925
International Prot ID:
IPI00291005
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0030060
GO:0004470
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
GO:0006108
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
Q
I
A
Y
S
L
L
Y
S
I
G
N
G
S
V
Site 2
S28
L
Y
S
I
G
N
G
S
V
F
G
K
D
Q
P
Site 3
S111
A
N
V
K
I
F
K
S
Q
G
A
A
L
D
K
Site 4
Y119
Q
G
A
A
L
D
K
Y
A
K
K
S
V
K
V
Site 5
T139
P
A
N
T
N
C
L
T
A
S
K
S
A
P
S
Site 6
S141
N
T
N
C
L
T
A
S
K
S
A
P
S
I
P
Site 7
S143
N
C
L
T
A
S
K
S
A
P
S
I
P
K
E
Site 8
S146
T
A
S
K
S
A
P
S
I
P
K
E
N
F
S
Site 9
S153
S
I
P
K
E
N
F
S
C
L
T
R
L
D
H
Site 10
Y192
G
N
H
S
S
T
Q
Y
P
D
V
N
H
A
K
Site 11
Y210
Q
G
K
E
V
G
V
Y
E
A
L
K
D
D
S
Site 12
S217
Y
E
A
L
K
D
D
S
W
L
K
G
E
F
V
Site 13
T226
L
K
G
E
F
V
T
T
V
Q
Q
R
G
A
A
Site 14
S241
V
I
K
A
R
K
L
S
S
A
M
S
A
A
K
Site 15
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Site 16
S245
R
K
L
S
S
A
M
S
A
A
K
A
I
C
D
Site 17
T261
V
R
D
I
W
F
G
T
P
E
G
E
F
V
S
Site 18
S268
T
P
E
G
E
F
V
S
M
G
V
I
S
D
G
Site 19
S277
G
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
Site 20
Y278
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
L
Site 21
T316
S
R
E
K
M
D
L
T
A
K
E
L
T
E
E
Site 22
S326
E
L
T
E
E
K
E
S
A
F
E
F
L
S
S
Site 23
S333
S
A
F
E
F
L
S
S
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation