KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MDH2
Full Name:
Malate dehydrogenase, mitochondrial
Alias:
malate dehydrogenase 2; malate dehydrogenase 2, NAD (mitochondrial); MDHM
Type:
Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; Oxidoreductase
Mass (Da):
35503
Number AA:
338
UniProt ID:
P40926
International Prot ID:
IPI00291006
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0030060
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
GO:0006108
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
A
L
A
R
P
A
S
A
A
L
R
R
S
F
Site 2
S16
A
S
A
A
L
R
R
S
F
S
T
S
A
Q
N
Site 3
S18
A
A
L
R
R
S
F
S
T
S
A
Q
N
N
A
Site 4
S20
L
R
R
S
F
S
T
S
A
Q
N
N
A
K
V
Site 5
S51
L
K
N
S
P
L
V
S
R
L
T
L
Y
D
I
Site 6
Y56
L
V
S
R
L
T
L
Y
D
I
A
H
T
P
G
Site 7
S69
P
G
V
A
A
D
L
S
H
I
E
T
K
A
A
Site 8
T73
A
D
L
S
H
I
E
T
K
A
A
V
K
G
Y
Site 9
Y80
T
K
A
A
V
K
G
Y
L
G
P
E
Q
L
P
Site 10
T109
V
P
R
K
P
G
M
T
R
D
D
L
F
N
T
Site 11
T151
V
N
S
T
I
P
I
T
A
E
V
F
K
K
H
Site 12
Y161
V
F
K
K
H
G
V
Y
N
P
N
K
I
F
G
Site 13
T171
N
K
I
F
G
V
T
T
L
D
I
V
R
A
N
Site 14
T224
D
F
P
Q
D
Q
L
T
A
L
T
G
R
I
Q
Site 15
T235
G
R
I
Q
E
A
G
T
E
V
V
K
A
K
A
Site 16
S246
K
A
K
A
G
A
G
S
A
T
L
S
M
A
Y
Site 17
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Site 18
S261
A
G
A
R
F
V
F
S
L
V
D
A
M
N
G
Site 19
S276
K
E
G
V
V
E
C
S
F
V
K
S
Q
E
T
Site 20
S280
V
E
C
S
F
V
K
S
Q
E
T
E
C
T
Y
Site 21
T283
S
F
V
K
S
Q
E
T
E
C
T
Y
F
S
T
Site 22
T286
K
S
Q
E
T
E
C
T
Y
F
S
T
P
L
L
Site 23
Y287
S
Q
E
T
E
C
T
Y
F
S
T
P
L
L
L
Site 24
T290
T
E
C
T
Y
F
S
T
P
L
L
L
G
K
K
Site 25
S309
N
L
G
I
G
K
V
S
S
F
E
E
K
M
I
Site 26
S317
S
F
E
E
K
M
I
S
D
A
I
P
E
L
K
Site 27
S326
A
I
P
E
L
K
A
S
I
K
K
G
E
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation