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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SILV
Full Name:
Melanocyte protein Pmel 17
Alias:
ME20-M;Melanocytes lineage-specific antigen GP100;Melanoma-associated ME20 antigen;P1;P100;Silver locus protein homolog;95 kDa melanocyte-specific secreted glycoprotein;P26;Secreted melanoma-associated ME20 antigen
Type:
Mass (Da):
70255
Number AA:
661
UniProt ID:
P40967
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y49
K
A
W
N
R
Q
L
Y
P
E
W
T
E
A
Q
Site 2
T53
R
Q
L
Y
P
E
W
T
E
A
Q
R
L
D
C
Site 3
S67
C
W
R
G
G
Q
V
S
L
K
V
S
N
D
G
Site 4
S71
G
Q
V
S
L
K
V
S
N
D
G
P
T
L
I
Site 5
Y122
V
W
G
G
Q
P
V
Y
P
Q
E
T
D
D
A
Site 6
S140
P
D
G
G
P
C
P
S
G
S
W
S
Q
K
R
Site 7
S142
G
G
P
C
P
S
G
S
W
S
Q
K
R
S
F
Site 8
S144
P
C
P
S
G
S
W
S
Q
K
R
S
F
V
Y
Site 9
Y151
S
Q
K
R
S
F
V
Y
V
W
K
T
W
G
Q
Site 10
T183
R
A
M
L
G
T
H
T
M
E
V
T
V
Y
H
Site 11
T187
G
T
H
T
M
E
V
T
V
Y
H
R
R
G
S
Site 12
Y189
H
T
M
E
V
T
V
Y
H
R
R
G
S
R
S
Site 13
S194
T
V
Y
H
R
R
G
S
R
S
Y
V
P
L
A
Site 14
S196
Y
H
R
R
G
S
R
S
Y
V
P
L
A
H
S
Site 15
Y197
H
R
R
G
S
R
S
Y
V
P
L
A
H
S
S
Site 16
T208
A
H
S
S
S
A
F
T
I
T
D
Q
V
P
F
Site 17
T239
F
L
R
N
Q
P
L
T
F
A
L
Q
L
H
D
Site 18
Y258
L
A
E
A
D
L
S
Y
T
W
D
F
G
D
S
Site 19
S266
T
W
D
F
G
D
S
S
G
T
L
I
S
R
A
Site 20
S304
P
L
T
S
C
G
S
S
P
V
P
G
T
T
D
Site 21
T316
T
T
D
G
H
R
P
T
A
E
A
P
N
T
T
Site 22
T322
P
T
A
E
A
P
N
T
T
A
G
Q
V
P
T
Site 23
T330
T
A
G
Q
V
P
T
T
E
V
V
G
T
T
P
Site 24
T335
P
T
T
E
V
V
G
T
T
P
G
Q
A
P
T
Site 25
T336
T
T
E
V
V
G
T
T
P
G
Q
A
P
T
A
Site 26
T342
T
T
P
G
Q
A
P
T
A
E
P
S
G
T
T
Site 27
S346
Q
A
P
T
A
E
P
S
G
T
T
S
V
Q
V
Site 28
T348
P
T
A
E
P
S
G
T
T
S
V
Q
V
P
T
Site 29
S350
A
E
P
S
G
T
T
S
V
Q
V
P
T
T
E
Site 30
T361
P
T
T
E
V
I
S
T
A
P
V
Q
M
P
T
Site 31
S371
V
Q
M
P
T
A
E
S
T
G
M
T
P
E
K
Site 32
T375
T
A
E
S
T
G
M
T
P
E
K
V
P
V
S
Site 33
S382
T
P
E
K
V
P
V
S
E
V
M
G
T
T
L
Site 34
T394
T
T
L
A
E
M
S
T
P
E
A
T
G
M
T
Site 35
T426
T
T
T
E
W
V
E
T
T
A
R
E
L
P
I
Site 36
S442
E
P
E
G
P
D
A
S
S
I
M
S
T
E
S
Site 37
S443
P
E
G
P
D
A
S
S
I
M
S
T
E
S
I
Site 38
S446
P
D
A
S
S
I
M
S
T
E
S
I
T
G
S
Site 39
T447
D
A
S
S
I
M
S
T
E
S
I
T
G
S
L
Site 40
S449
S
S
I
M
S
T
E
S
I
T
G
S
L
G
P
Site 41
S453
S
T
E
S
I
T
G
S
L
G
P
L
L
D
G
Site 42
T463
P
L
L
D
G
T
A
T
L
R
L
V
K
R
Q
Site 43
S504
E
I
L
Q
A
V
P
S
G
E
G
D
A
F
E
Site 44
S515
D
A
F
E
L
T
V
S
C
Q
G
G
L
P
K
Site 45
S530
E
A
C
M
E
I
S
S
P
G
C
Q
P
P
A
Site 46
S626
R
L
M
K
Q
D
F
S
V
P
Q
L
P
H
S
Site 47
S633
S
V
P
Q
L
P
H
S
S
S
H
W
L
R
L
Site 48
S635
P
Q
L
P
H
S
S
S
H
W
L
R
L
P
R
Site 49
S646
R
L
P
R
I
F
C
S
C
P
I
G
E
N
S
Site 50
S653
S
C
P
I
G
E
N
S
P
L
L
S
G
Q
Q
Site 51
S657
G
E
N
S
P
L
L
S
G
Q
Q
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation