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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
eIF2S3
Full Name:
Eukaryotic translation initiation factor 2 subunit 3
Alias:
EIF2; EIF2G; EIF2gamma; EIF-2-gamma; Eukaryotic translation initiation factor 2 gamma subunit; Eukaryotic translation initiation factor 2 subunit gamma; Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; Eukaryotic translation initiation factor 2G; IF2G
Type:
Translation
Mass (Da):
51091
Number AA:
472
UniProt ID:
P41091
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
G
G
E
A
G
V
T
L
G
Q
P
H
L
S
Site 2
S16
T
L
G
Q
P
H
L
S
R
Q
D
L
T
T
L
Site 3
T21
H
L
S
R
Q
D
L
T
T
L
D
V
T
K
L
Site 4
T22
L
S
R
Q
D
L
T
T
L
D
V
T
K
L
T
Site 5
S32
V
T
K
L
T
P
L
S
H
E
V
I
S
R
Q
Site 6
S55
G
H
V
A
H
G
K
S
T
V
V
K
A
I
S
Site 7
T56
H
V
A
H
G
K
S
T
V
V
K
A
I
S
G
Site 8
T66
K
A
I
S
G
V
H
T
V
R
F
K
N
E
L
Site 9
T78
N
E
L
E
R
N
I
T
I
K
L
G
Y
A
N
Site 10
Y89
G
Y
A
N
A
K
I
Y
K
L
D
D
P
S
C
Site 11
Y102
S
C
P
R
P
E
C
Y
R
S
C
G
S
S
T
Site 12
S104
P
R
P
E
C
Y
R
S
C
G
S
S
T
P
D
Site 13
S108
C
Y
R
S
C
G
S
S
T
P
D
E
F
P
T
Site 14
T109
Y
R
S
C
G
S
S
T
P
D
E
F
P
T
D
Site 15
T115
S
T
P
D
E
F
P
T
D
I
P
G
T
K
G
Site 16
S198
K
I
D
L
V
K
E
S
Q
A
K
E
Q
Y
E
Site 17
Y238
N
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Site 18
T251
P
V
P
P
R
D
F
T
S
E
P
R
L
I
V
Site 19
S261
P
R
L
I
V
I
R
S
F
D
V
N
K
P
G
Site 20
S302
E
V
R
P
G
I
V
S
K
D
S
E
G
K
L
Site 21
S305
P
G
I
V
S
K
D
S
E
G
K
L
M
C
K
Site 22
Y330
A
E
H
N
D
L
Q
Y
A
A
P
G
G
L
I
Site 23
T346
V
G
T
K
I
D
P
T
L
C
R
A
D
R
M
Site 24
S412
M
V
N
I
G
S
L
S
T
G
G
R
V
S
A
Site 25
T413
V
N
I
G
S
L
S
T
G
G
R
V
S
A
V
Site 26
S418
L
S
T
G
G
R
V
S
A
V
K
A
D
L
G
Site 27
T435
V
L
T
N
P
V
C
T
E
V
G
E
K
I
A
Site 28
S444
V
G
E
K
I
A
L
S
R
R
V
E
K
H
W
Site 29
T464
G
Q
I
R
R
G
V
T
I
K
P
T
V
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation