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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RGS2
Full Name:
Regulator of G-protein signaling 2
Alias:
Cell growth-inhibiting 31; G0 to G1 switch regulatory 8, 24kD; G0/G1 switch regulatory 8; G0S8; Regulator of G-protein signaling 2, 24kDa; Regulator of G-protein signalling 2, 24kDa
Type:
GTPase activating protein, misc.
Mass (Da):
24382
Number AA:
211
UniProt ID:
P41220
International Prot ID:
IPI00013177
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005516
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0009968
GO:0008277
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
D
C
R
P
M
D
K
S
A
G
S
G
H
K
S
Site 2
S22
P
M
D
K
S
A
G
S
G
H
K
S
E
E
K
Site 3
S26
S
A
G
S
G
H
K
S
E
E
K
R
E
K
M
Site 4
T43
T
L
L
K
D
W
K
T
R
L
S
Y
F
L
Q
Site 5
S46
K
D
W
K
T
R
L
S
Y
F
L
Q
N
S
S
Site 6
Y47
D
W
K
T
R
L
S
Y
F
L
Q
N
S
S
T
Site 7
S52
L
S
Y
F
L
Q
N
S
S
T
P
G
K
P
K
Site 8
S53
S
Y
F
L
Q
N
S
S
T
P
G
K
P
K
T
Site 9
T54
Y
F
L
Q
N
S
S
T
P
G
K
P
K
T
G
Site 10
T60
S
T
P
G
K
P
K
T
G
K
K
S
K
Q
Q
Site 11
S64
K
P
K
T
G
K
K
S
K
Q
Q
A
F
I
K
Site 12
S73
Q
Q
A
F
I
K
P
S
P
E
E
A
Q
L
W
Site 13
S103
A
F
R
A
F
L
K
S
E
F
C
E
E
N
I
Site 14
S124
E
D
F
K
K
T
K
S
P
Q
K
L
S
S
K
Site 15
S130
K
S
P
Q
K
L
S
S
K
A
R
K
I
Y
T
Site 16
Y136
S
S
K
A
R
K
I
Y
T
D
F
I
E
K
E
Site 17
T156
N
I
D
F
Q
T
K
T
L
I
A
Q
N
I
Q
Site 18
S167
Q
N
I
Q
E
A
T
S
G
C
F
T
T
A
Q
Site 19
T171
E
A
T
S
G
C
F
T
T
A
Q
K
R
V
Y
Site 20
Y178
T
T
A
Q
K
R
V
Y
S
L
M
E
N
N
S
Site 21
S179
T
A
Q
K
R
V
Y
S
L
M
E
N
N
S
Y
Site 22
S185
Y
S
L
M
E
N
N
S
Y
P
R
F
L
E
S
Site 23
Y186
S
L
M
E
N
N
S
Y
P
R
F
L
E
S
E
Site 24
S192
S
Y
P
R
F
L
E
S
E
F
Y
Q
D
L
C
Site 25
Y195
R
F
L
E
S
E
F
Y
Q
D
L
C
K
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation