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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GARS
Full Name:
Glycyl-tRNA synthetase
Alias:
Charcot-Marie-Tooth neuropathy 2D; CMT2D; DSMAV; EC 6.1.1.14; Glycine tRNA ligase; Glycine-tRNA ligase; Glycine--tRNA ligase; GlyRS; SMAD1; SYG
Type:
Enzyme, phosphoribosylamine-glycine ligase
Mass (Da):
83140
Number AA:
739
UniProt ID:
P41250
International Prot ID:
IPI00025273
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005759
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004820
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0006426
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
P
R
L
L
A
R
P
S
L
L
L
R
R
S
L
Site 2
S51
I
S
L
P
A
A
A
S
R
S
S
M
D
G
A
Site 3
S53
L
P
A
A
A
S
R
S
S
M
D
G
A
G
A
Site 4
S54
P
A
A
A
S
R
S
S
M
D
G
A
G
A
E
Site 5
T127
D
R
A
K
M
E
D
T
L
K
R
R
F
F
Y
Site 6
Y134
T
L
K
R
R
F
F
Y
D
Q
A
F
A
I
Y
Site 7
Y141
Y
D
Q
A
F
A
I
Y
G
G
V
S
G
L
Y
Site 8
Y148
Y
G
G
V
S
G
L
Y
D
F
G
P
V
G
C
Site 9
T191
T
P
E
P
V
L
K
T
S
G
H
V
D
K
F
Site 10
S192
P
E
P
V
L
K
T
S
G
H
V
D
K
F
A
Site 11
S227
A
H
L
Q
K
L
M
S
D
K
K
C
S
V
E
Site 12
S232
L
M
S
D
K
K
C
S
V
E
K
K
S
E
M
Site 13
S237
K
C
S
V
E
K
K
S
E
M
E
S
V
L
A
Site 14
S241
E
K
K
S
E
M
E
S
V
L
A
Q
L
D
N
Site 15
Y249
V
L
A
Q
L
D
N
Y
G
Q
Q
E
L
A
D
Site 16
S265
F
V
N
Y
N
V
K
S
P
I
T
G
N
D
L
Site 17
S273
P
I
T
G
N
D
L
S
P
P
V
S
F
N
L
Site 18
S277
N
D
L
S
P
P
V
S
F
N
L
M
F
K
T
Site 19
Y295
P
G
G
N
M
P
G
Y
L
R
P
E
T
A
Q
Site 20
T300
P
G
Y
L
R
P
E
T
A
Q
G
I
F
L
N
Site 21
S329
A
A
A
Q
I
G
N
S
F
R
N
E
I
S
P
Site 22
S335
N
S
F
R
N
E
I
S
P
R
S
G
L
I
R
Site 23
S338
R
N
E
I
S
P
R
S
G
L
I
R
V
R
E
Site 24
T347
L
I
R
V
R
E
F
T
M
A
E
I
E
H
F
Site 25
Y374
N
V
A
D
L
H
L
Y
L
Y
S
A
K
A
Q
Site 26
S386
K
A
Q
V
S
G
Q
S
A
R
K
M
R
L
G
Site 27
S423
Y
L
T
K
V
G
I
S
P
D
K
L
R
F
R
Site 28
Y453
D
A
E
S
K
T
S
Y
G
W
I
E
I
V
G
Site 29
Y467
G
C
A
D
R
S
C
Y
D
L
S
C
H
A
R
Site 30
S470
D
R
S
C
Y
D
L
S
C
H
A
R
A
T
K
Site 31
T491
K
P
L
K
E
P
K
T
V
N
V
V
Q
F
E
Site 32
Y518
D
A
K
L
V
M
E
Y
L
A
I
C
D
E
C
Site 33
T548
T
I
E
T
E
G
K
T
F
Q
L
T
K
D
M
Site 34
T552
E
G
K
T
F
Q
L
T
K
D
M
I
N
V
K
Site 35
T564
N
V
K
R
F
Q
K
T
L
Y
V
E
E
V
V
Site 36
Y566
K
R
F
Q
K
T
L
Y
V
E
E
V
V
P
N
Site 37
T603
R
E
G
D
E
Q
R
T
F
F
S
F
P
A
V
Site 38
S606
D
E
Q
R
T
F
F
S
F
P
A
V
V
A
P
Site 39
S622
K
C
S
V
L
P
L
S
Q
N
Q
E
F
M
P
Site 40
S635
M
P
F
V
K
E
L
S
E
A
L
T
R
H
G
Site 41
T639
K
E
L
S
E
A
L
T
R
H
G
V
S
H
K
Site 42
S650
V
S
H
K
V
D
D
S
S
G
S
I
G
R
R
Site 43
S651
S
H
K
V
D
D
S
S
G
S
I
G
R
R
Y
Site 44
S653
K
V
D
D
S
S
G
S
I
G
R
R
Y
A
R
Site 45
Y658
S
G
S
I
G
R
R
Y
A
R
T
D
E
I
G
Site 46
T661
I
G
R
R
Y
A
R
T
D
E
I
G
V
A
F
Site 47
T676
G
V
T
I
D
F
D
T
V
N
K
T
P
H
T
Site 48
T680
D
F
D
T
V
N
K
T
P
H
T
A
T
L
R
Site 49
T685
N
K
T
P
H
T
A
T
L
R
D
R
D
S
M
Site 50
S691
A
T
L
R
D
R
D
S
M
R
Q
I
R
A
E
Site 51
S700
R
Q
I
R
A
E
I
S
E
L
P
S
I
V
Q
Site 52
Y723
W
A
D
V
E
A
R
Y
P
L
F
E
G
Q
E
Site 53
T731
P
L
F
E
G
Q
E
T
G
K
K
E
T
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation