KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IARS
Full Name:
Isoleucyl-tRNA synthetase, cytoplasmic
Alias:
IARS1; IleRS; ILRS; IRS; Isoleucine tRNA ligase 1, cytoplasmic; Isoleucine--tRNA ligase; Isoleucyl-tRNA synthetase; SYI; SYIC
Type:
Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Ligase; EC 6.1.1.5
Mass (Da):
144498
Number AA:
1262
UniProt ID:
P41252
International Prot ID:
IPI00644127
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004822
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006428
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T42
S
K
H
K
P
K
F
T
F
Y
D
G
P
P
F
Site 2
Y44
H
K
P
K
F
T
F
Y
D
G
P
P
F
A
T
Site 3
T69
G
T
I
K
D
I
V
T
R
Y
A
H
Q
S
G
Site 4
Y71
I
K
D
I
V
T
R
Y
A
H
Q
S
G
F
H
Site 5
S75
V
T
R
Y
A
H
Q
S
G
F
H
V
D
R
R
Site 6
T99
V
E
Y
E
I
D
K
T
L
G
I
R
G
P
E
Site 7
Y116
A
K
M
G
I
T
E
Y
N
N
Q
C
R
A
I
Site 8
S128
R
A
I
V
M
R
Y
S
A
E
W
K
S
T
V
Site 9
S133
R
Y
S
A
E
W
K
S
T
V
S
R
L
G
R
Site 10
T134
Y
S
A
E
W
K
S
T
V
S
R
L
G
R
W
Site 11
Y148
W
I
D
F
D
N
D
Y
K
T
L
Y
P
Q
F
Site 12
Y152
D
N
D
Y
K
T
L
Y
P
Q
F
M
E
S
V
Site 13
Y167
W
W
V
F
K
Q
L
Y
D
K
G
L
V
Y
R
Site 14
Y173
L
Y
D
K
G
L
V
Y
R
G
V
K
V
M
P
Site 15
T187
P
F
S
T
A
C
N
T
P
L
S
N
F
E
S
Site 16
S190
T
A
C
N
T
P
L
S
N
F
E
S
H
Q
N
Site 17
S194
T
P
L
S
N
F
E
S
H
Q
N
Y
K
D
V
Site 18
Y198
N
F
E
S
H
Q
N
Y
K
D
V
Q
D
P
S
Site 19
T209
Q
D
P
S
V
F
V
T
F
P
L
E
E
D
E
Site 20
S219
L
E
E
D
E
T
V
S
L
V
A
W
T
T
T
Site 21
T226
S
L
V
A
W
T
T
T
P
W
T
L
P
S
N
Site 22
Y244
C
V
N
P
E
M
Q
Y
V
K
I
K
D
V
A
Site 23
S264
I
L
M
E
A
R
L
S
A
L
Y
K
L
E
S
Site 24
Y267
E
A
R
L
S
A
L
Y
K
L
E
S
D
Y
E
Site 25
S271
S
A
L
Y
K
L
E
S
D
Y
E
I
L
E
R
Site 26
Y273
L
Y
K
L
E
S
D
Y
E
I
L
E
R
F
P
Site 27
Y283
L
E
R
F
P
G
A
Y
L
K
G
K
K
Y
R
Site 28
Y289
A
Y
L
K
G
K
K
Y
R
P
L
F
D
Y
F
Site 29
Y295
K
Y
R
P
L
F
D
Y
F
L
K
C
K
E
N
Site 30
Y312
F
T
V
L
V
D
N
Y
V
K
E
E
E
G
T
Site 31
T319
Y
V
K
E
E
E
G
T
G
V
V
H
Q
A
P
Site 32
Y327
G
V
V
H
Q
A
P
Y
F
G
A
E
D
Y
R
Site 33
Y333
P
Y
F
G
A
E
D
Y
R
V
C
M
D
F
N
Site 34
Y369
V
T
D
F
A
G
Q
Y
V
K
D
A
D
K
S
Site 35
S376
Y
V
K
D
A
D
K
S
I
I
R
T
L
K
E
Site 36
T380
A
D
K
S
I
I
R
T
L
K
E
Q
G
R
L
Site 37
T391
Q
G
R
L
L
V
A
T
T
F
T
H
S
Y
P
Site 38
T405
P
F
C
W
R
S
D
T
P
L
I
Y
K
A
V
Site 39
Y409
R
S
D
T
P
L
I
Y
K
A
V
P
S
W
F
Site 40
Y434
L
R
N
N
D
L
C
Y
W
V
P
E
L
V
R
Site 41
Y462
W
T
I
S
R
N
R
Y
W
G
T
P
I
P
L
Site 42
T465
S
R
N
R
Y
W
G
T
P
I
P
L
W
V
S
Site 43
S496
E
L
S
G
A
K
I
S
D
L
H
R
E
S
V
Site 44
S502
I
S
D
L
H
R
E
S
V
D
H
L
T
I
P
Site 45
T507
R
E
S
V
D
H
L
T
I
P
S
R
C
G
K
Site 46
S510
V
D
H
L
T
I
P
S
R
C
G
K
G
S
L
Site 47
S516
P
S
R
C
G
K
G
S
L
H
R
I
S
E
V
Site 48
T564
I
A
E
G
I
D
Q
T
R
G
W
F
Y
T
L
Site 49
S602
A
S
D
G
Q
K
M
S
K
R
K
K
N
Y
P
Site 50
Y608
M
S
K
R
K
K
N
Y
P
D
P
V
S
I
I
Site 51
S613
K
N
Y
P
D
P
V
S
I
I
Q
K
Y
G
A
Site 52
Y680
E
E
E
I
E
F
L
Y
N
E
N
T
V
R
E
Site 53
T684
E
F
L
Y
N
E
N
T
V
R
E
S
P
N
I
Site 54
S688
N
E
N
T
V
R
E
S
P
N
I
T
D
R
W
Site 55
T692
V
R
E
S
P
N
I
T
D
R
W
I
L
S
F
Site 56
T718
M
A
A
Y
R
L
Y
T
V
V
P
R
L
V
K
Site 57
Y734
V
D
I
L
T
N
W
Y
V
R
M
N
R
R
R
Site 58
S792
K
V
L
I
D
P
V
S
V
Q
D
K
D
T
L
Site 59
T798
V
S
V
Q
D
K
D
T
L
S
I
H
Y
L
M
Site 60
S800
V
Q
D
K
D
T
L
S
I
H
Y
L
M
L
P
Site 61
T818
E
E
L
I
D
K
K
T
E
S
A
V
S
Q
M
Site 62
S820
L
I
D
K
K
T
E
S
A
V
S
Q
M
Q
S
Site 63
S823
K
K
T
E
S
A
V
S
Q
M
Q
S
V
I
E
Site 64
T840
R
V
I
R
D
R
K
T
I
P
I
K
Y
P
L
Site 65
S865
E
A
L
K
D
I
K
S
L
E
K
Y
I
I
E
Site 66
Y869
D
I
K
S
L
E
K
Y
I
I
E
E
L
N
V
Site 67
T880
E
L
N
V
R
K
V
T
L
S
T
D
K
N
K
Site 68
S882
N
V
R
K
V
T
L
S
T
D
K
N
K
Y
G
Site 69
Y888
L
S
T
D
K
N
K
Y
G
I
R
L
R
A
E
Site 70
S915
A
F
K
A
V
M
T
S
I
K
Q
L
S
S
E
Site 71
S920
M
T
S
I
K
Q
L
S
S
E
E
L
E
Q
F
Site 72
T932
E
Q
F
Q
K
T
G
T
I
V
V
E
G
H
E
Site 73
Y949
D
E
D
I
R
L
M
Y
T
F
D
Q
A
T
G
Site 74
T950
E
D
I
R
L
M
Y
T
F
D
Q
A
T
G
G
Site 75
S980
L
D
V
T
P
D
Q
S
M
V
D
E
G
M
A
Site 76
T1010
L
V
P
T
D
E
I
T
V
Y
Y
K
A
K
S
Site 77
Y1012
P
T
D
E
I
T
V
Y
Y
K
A
K
S
E
G
Site 78
Y1013
T
D
E
I
T
V
Y
Y
K
A
K
S
E
G
T
Site 79
S1017
T
V
Y
Y
K
A
K
S
E
G
T
Y
L
N
S
Site 80
Y1021
K
A
K
S
E
G
T
Y
L
N
S
V
I
E
S
Site 81
S1024
S
E
G
T
Y
L
N
S
V
I
E
S
H
T
E
Site 82
T1035
S
H
T
E
F
I
F
T
T
I
K
A
P
L
K
Site 83
Y1044
I
K
A
P
L
K
P
Y
P
V
S
P
S
D
K
Site 84
S1047
P
L
K
P
Y
P
V
S
P
S
D
K
V
L
I
Site 85
S1049
K
P
Y
P
V
S
P
S
D
K
V
L
I
Q
E
Site 86
T1058
K
V
L
I
Q
E
K
T
Q
L
K
G
S
E
L
Site 87
T1068
K
G
S
E
L
E
I
T
L
T
R
G
S
S
L
Site 88
T1070
S
E
L
E
I
T
L
T
R
G
S
S
L
P
G
Site 89
S1073
E
I
T
L
T
R
G
S
S
L
P
G
P
A
C
Site 90
T1136
L
A
V
F
H
D
E
T
E
I
Q
N
Q
T
D
Site 91
T1142
E
T
E
I
Q
N
Q
T
D
L
L
S
L
S
G
Site 92
S1146
Q
N
Q
T
D
L
L
S
L
S
G
K
T
L
C
Site 93
T1206
P
L
G
Q
N
G
L
T
H
Q
G
L
L
Y
E
Site 94
T1245
T
E
D
I
P
V
K
T
L
N
M
K
T
V
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation