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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HTR2b
Full Name:
5-hydroxytryptamine receptor 2B
Alias:
5-HT(2b); 5-HT2b
Type:
Receptor - G protein-coupled; Plasma membrane, iIntegral plasma membrane protein
Mass (Da):
54298
Number AA:
481
UniProt ID:
P41595
International Prot ID:
IPI00015134
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0051378
GO:0004993
PhosphoSite+
KinaseNET
Biological Process:
GO:0007200
GO:0008015
GO:0043123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
L
S
Y
R
V
S
E
L
Q
S
T
I
P
Site 2
S12
Y
R
V
S
E
L
Q
S
T
I
P
E
H
I
L
Site 3
T13
R
V
S
E
L
Q
S
T
I
P
E
H
I
L
Q
Site 4
S32
H
V
I
S
S
N
W
S
G
L
Q
T
E
S
I
Site 5
T36
S
N
W
S
G
L
Q
T
E
S
I
P
E
E
M
Site 6
Y166
K
P
I
Q
A
N
Q
Y
N
S
R
A
T
A
F
Site 7
T171
N
Q
Y
N
S
R
A
T
A
F
I
K
I
T
V
Site 8
T210
N
N
I
T
C
V
L
T
K
E
R
F
G
D
F
Site 9
Y249
H
A
L
Q
K
K
A
Y
L
V
K
N
K
P
P
Site 10
T260
N
K
P
P
Q
R
L
T
W
L
T
V
S
T
V
Site 11
T263
P
Q
R
L
T
W
L
T
V
S
T
V
F
Q
R
Site 12
T273
T
V
F
Q
R
D
E
T
P
C
S
S
P
E
K
Site 13
S276
Q
R
D
E
T
P
C
S
S
P
E
K
V
A
M
Site 14
S277
R
D
E
T
P
C
S
S
P
E
K
V
A
M
L
Site 15
S296
K
D
K
A
L
P
N
S
G
D
E
T
L
M
R
Site 16
T300
L
P
N
S
G
D
E
T
L
M
R
R
T
S
T
Site 17
T305
D
E
T
L
M
R
R
T
S
T
I
G
K
K
S
Site 18
S306
E
T
L
M
R
R
T
S
T
I
G
K
K
S
V
Site 19
T307
T
L
M
R
R
T
S
T
I
G
K
K
S
V
Q
Site 20
S312
T
S
T
I
G
K
K
S
V
Q
T
I
S
N
E
Site 21
T386
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Site 22
T396
D
A
F
G
R
Y
I
T
C
N
Y
R
A
T
K
Site 23
Y399
G
R
Y
I
T
C
N
Y
R
A
T
K
S
V
K
Site 24
T402
I
T
C
N
Y
R
A
T
K
S
V
K
T
L
R
Site 25
S404
C
N
Y
R
A
T
K
S
V
K
T
L
R
K
R
Site 26
T407
R
A
T
K
S
V
K
T
L
R
K
R
S
S
K
Site 27
S412
V
K
T
L
R
K
R
S
S
K
I
Y
F
R
N
Site 28
S413
K
T
L
R
K
R
S
S
K
I
Y
F
R
N
P
Site 29
Y416
R
K
R
S
S
K
I
Y
F
R
N
P
M
A
E
Site 30
Y442
N
G
I
N
P
A
M
Y
Q
S
P
M
R
L
R
Site 31
S444
I
N
P
A
M
Y
Q
S
P
M
R
L
R
S
S
Site 32
S450
Q
S
P
M
R
L
R
S
S
T
I
Q
S
S
S
Site 33
S451
S
P
M
R
L
R
S
S
T
I
Q
S
S
S
I
Site 34
T452
P
M
R
L
R
S
S
T
I
Q
S
S
S
I
I
Site 35
S456
R
S
S
T
I
Q
S
S
S
I
I
L
L
D
T
Site 36
T474
T
E
N
E
G
D
K
T
E
E
Q
V
S
Y
V
Site 37
Y480
K
T
E
E
Q
V
S
Y
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation