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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMPO
Full Name:
Lamina-associated polypeptide 2, isoform alpha
Alias:
Lamina-associated polypeptide 2 isoform alpha; LAP2; LEM domain containing 4; LEMD4; Splenin; Thymopoietin; Thymopoietin isoform alpha; Thymopoietin-related peptide isoform alpha; TP; TP alpha; TP5; TPRP isoform alpha
Type:
Structural protein, nucleus
Mass (Da):
75492
Number AA:
694
UniProt ID:
P42166
International Prot ID:
IPI00216230
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005635
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005521
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
E
F
L
E
D
P
S
V
L
T
K
D
K
L
Site 2
S18
L
T
K
D
K
L
K
S
E
L
V
A
N
N
V
Site 3
Y37
G
E
Q
R
K
D
V
Y
V
Q
L
Y
L
Q
H
Site 4
Y41
K
D
V
Y
V
Q
L
Y
L
Q
H
L
T
A
R
Site 5
T46
Q
L
Y
L
Q
H
L
T
A
R
N
R
P
P
L
Site 6
T57
R
P
P
L
P
A
G
T
N
S
K
G
P
P
D
Site 7
S59
P
L
P
A
G
T
N
S
K
G
P
P
D
F
S
Site 8
S66
S
K
G
P
P
D
F
S
S
D
E
E
R
E
P
Site 9
S67
K
G
P
P
D
F
S
S
D
E
E
R
E
P
T
Site 10
T74
S
D
E
E
R
E
P
T
P
V
L
G
S
G
A
Site 11
S79
E
P
T
P
V
L
G
S
G
A
A
A
A
G
R
Site 12
S87
G
A
A
A
A
G
R
S
R
A
A
V
G
R
K
Site 13
T96
A
A
V
G
R
K
A
T
K
K
T
D
K
P
R
Site 14
T99
G
R
K
A
T
K
K
T
D
K
P
R
Q
E
D
Site 15
T113
D
K
D
D
L
D
V
T
E
L
T
N
E
D
L
Site 16
T137
N
P
G
P
I
V
G
T
T
R
K
L
Y
E
K
Site 17
Y142
V
G
T
T
R
K
L
Y
E
K
K
L
L
K
L
Site 18
T154
L
K
L
R
E
Q
G
T
E
S
R
S
S
T
P
Site 19
S156
L
R
E
Q
G
T
E
S
R
S
S
T
P
L
P
Site 20
S158
E
Q
G
T
E
S
R
S
S
T
P
L
P
T
I
Site 21
S159
Q
G
T
E
S
R
S
S
T
P
L
P
T
I
S
Site 22
T160
G
T
E
S
R
S
S
T
P
L
P
T
I
S
S
Site 23
T164
R
S
S
T
P
L
P
T
I
S
S
S
A
E
N
Site 24
S166
S
T
P
L
P
T
I
S
S
S
A
E
N
T
R
Site 25
S167
T
P
L
P
T
I
S
S
S
A
E
N
T
R
Q
Site 26
S168
P
L
P
T
I
S
S
S
A
E
N
T
R
Q
N
Site 27
T172
I
S
S
S
A
E
N
T
R
Q
N
G
S
N
D
Site 28
S177
E
N
T
R
Q
N
G
S
N
D
S
D
R
Y
S
Site 29
S180
R
Q
N
G
S
N
D
S
D
R
Y
S
D
N
E
Site 30
Y183
G
S
N
D
S
D
R
Y
S
D
N
E
E
G
K
Site 31
S184
S
N
D
S
D
R
Y
S
D
N
E
E
G
K
K
Site 32
S199
K
E
H
K
K
V
K
S
T
R
D
I
V
P
F
Site 33
S207
T
R
D
I
V
P
F
S
E
L
G
T
T
P
S
Site 34
T212
P
F
S
E
L
G
T
T
P
S
G
G
G
F
F
Site 35
S214
S
E
L
G
T
T
P
S
G
G
G
F
F
Q
G
Site 36
S223
G
G
F
F
Q
G
I
S
F
P
E
I
S
T
R
Site 37
S228
G
I
S
F
P
E
I
S
T
R
P
P
L
G
S
Site 38
T229
I
S
F
P
E
I
S
T
R
P
P
L
G
S
T
Site 39
S235
S
T
R
P
P
L
G
S
T
E
L
Q
A
A
K
Site 40
T259
P
R
E
P
L
V
A
T
N
L
P
G
R
G
Q
Site 41
S272
G
Q
L
Q
K
L
A
S
E
R
N
L
F
I
S
Site 42
S279
S
E
R
N
L
F
I
S
C
K
S
S
H
D
R
Site 43
S283
L
F
I
S
C
K
S
S
H
D
R
C
L
E
K
Site 44
S291
H
D
R
C
L
E
K
S
S
S
S
S
S
Q
P
Site 45
S292
D
R
C
L
E
K
S
S
S
S
S
S
Q
P
E
Site 46
S293
R
C
L
E
K
S
S
S
S
S
S
Q
P
E
H
Site 47
S294
C
L
E
K
S
S
S
S
S
S
Q
P
E
H
S
Site 48
S295
L
E
K
S
S
S
S
S
S
Q
P
E
H
S
A
Site 49
S296
E
K
S
S
S
S
S
S
Q
P
E
H
S
A
M
Site 50
S301
S
S
S
Q
P
E
H
S
A
M
L
V
S
T
A
Site 51
S306
E
H
S
A
M
L
V
S
T
A
A
S
P
S
L
Site 52
S310
M
L
V
S
T
A
A
S
P
S
L
I
K
E
T
Site 53
S312
V
S
T
A
A
S
P
S
L
I
K
E
T
T
T
Site 54
S335
N
I
C
G
R
E
K
S
G
I
Q
P
L
C
P
Site 55
S345
Q
P
L
C
P
E
R
S
H
I
S
D
Q
S
P
Site 56
S348
C
P
E
R
S
H
I
S
D
Q
S
P
L
S
S
Site 57
S351
R
S
H
I
S
D
Q
S
P
L
S
S
K
R
K
Site 58
S354
I
S
D
Q
S
P
L
S
S
K
R
K
A
L
E
Site 59
S355
S
D
Q
S
P
L
S
S
K
R
K
A
L
E
E
Site 60
S363
K
R
K
A
L
E
E
S
E
S
S
Q
L
I
S
Site 61
S365
K
A
L
E
E
S
E
S
S
Q
L
I
S
P
P
Site 62
S366
A
L
E
E
S
E
S
S
Q
L
I
S
P
P
L
Site 63
S370
S
E
S
S
Q
L
I
S
P
P
L
A
Q
A
I
Site 64
S392
L
V
Q
G
G
V
G
S
L
P
G
T
S
N
S
Site 65
T396
G
V
G
S
L
P
G
T
S
N
S
M
P
P
L
Site 66
S397
V
G
S
L
P
G
T
S
N
S
M
P
P
L
D
Site 67
S399
S
L
P
G
T
S
N
S
M
P
P
L
D
V
E
Site 68
S415
I
Q
K
R
I
D
Q
S
K
F
Q
E
T
E
F
Site 69
T420
D
Q
S
K
F
Q
E
T
E
F
L
S
P
P
R
Site 70
S424
F
Q
E
T
E
F
L
S
P
P
R
K
V
P
R
Site 71
S433
P
R
K
V
P
R
L
S
E
K
S
V
E
E
R
Site 72
S436
V
P
R
L
S
E
K
S
V
E
E
R
D
S
G
Site 73
S442
K
S
V
E
E
R
D
S
G
S
F
V
A
F
Q
Site 74
S444
V
E
E
R
D
S
G
S
F
V
A
F
Q
N
I
Site 75
S458
I
P
G
S
E
L
M
S
S
F
A
K
T
V
V
Site 76
S488
Q
H
D
K
I
D
A
S
E
L
S
F
P
F
H
Site 77
S491
K
I
D
A
S
E
L
S
F
P
F
H
E
S
I
Site 78
S515
Q
V
D
R
Q
L
P
S
L
A
C
K
Y
P
V
Site 79
Y520
L
P
S
L
A
C
K
Y
P
V
S
S
R
E
A
Site 80
S523
L
A
C
K
Y
P
V
S
S
R
E
A
T
Q
I
Site 81
T528
P
V
S
S
R
E
A
T
Q
I
L
S
V
P
K
Site 82
S557
L
G
G
I
Q
A
A
S
T
E
S
C
N
Q
Q
Site 83
S605
S
Q
A
A
Q
I
L
S
S
D
P
S
R
T
H
Site 84
S606
Q
A
A
Q
I
L
S
S
D
P
S
R
T
H
Q
Site 85
S609
Q
I
L
S
S
D
P
S
R
T
H
Q
A
L
G
Site 86
S626
S
K
T
Y
D
A
A
S
Y
I
C
E
A
A
F
Site 87
T642
E
V
K
M
A
A
H
T
M
G
N
A
T
V
G
Site 88
T647
A
H
T
M
G
N
A
T
V
G
R
R
Y
L
W
Site 89
Y652
N
A
T
V
G
R
R
Y
L
W
L
K
D
C
K
Site 90
S670
A
S
K
N
K
L
A
S
T
P
F
K
G
G
T
Site 91
T671
S
K
N
K
L
A
S
T
P
F
K
G
G
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation