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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAT5A
Full Name:
Signal transducer and activator of transcription 5A
Alias:
Mammary gland factor; MGF; MPF; STA5A; STAT5
Type:
Transcription protein
Mass (Da):
90647
Number AA:
794
UniProt ID:
P42229
International Prot ID:
IPI00030783
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006103
GO:0000255
GO:0006101
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
L
R
Q
M
Q
V
L
Y
G
Q
H
F
P
I
E
Site 2
Y33
F
P
I
E
V
R
H
Y
L
A
Q
W
I
E
S
Site 3
Y90
L
K
I
K
L
G
H
Y
A
T
Q
L
Q
K
T
Site 4
T92
I
K
L
G
H
Y
A
T
Q
L
Q
K
T
Y
D
Site 5
T97
Y
A
T
Q
L
Q
K
T
Y
D
R
C
P
L
E
Site 6
Y98
A
T
Q
L
Q
K
T
Y
D
R
C
P
L
E
L
Site 7
Y114
R
C
I
R
H
I
L
Y
N
E
Q
R
L
V
R
Site 8
S127
V
R
E
A
N
N
C
S
S
P
A
G
I
L
V
Site 9
S128
R
E
A
N
N
C
S
S
P
A
G
I
L
V
D
Site 10
T147
K
H
L
Q
I
N
Q
T
F
E
E
L
R
L
V
Site 11
T155
F
E
E
L
R
L
V
T
Q
D
T
E
N
E
L
Site 12
T158
L
R
L
V
T
Q
D
T
E
N
E
L
K
K
L
Site 13
Y171
K
L
Q
Q
T
Q
E
Y
F
I
I
Q
Y
Q
E
Site 14
Y176
Q
E
Y
F
I
I
Q
Y
Q
E
S
L
R
I
Q
Site 15
S193
F
A
Q
L
A
Q
L
S
P
Q
E
R
L
S
R
Site 16
S199
L
S
P
Q
E
R
L
S
R
E
T
A
L
Q
Q
Site 17
T202
Q
E
R
L
S
R
E
T
A
L
Q
Q
K
Q
V
Site 18
T245
Q
L
L
R
K
Q
Q
T
I
I
L
D
D
E
L
Site 19
S271
N
G
G
P
P
E
G
S
L
D
V
L
Q
S
W
Site 20
S277
G
S
L
D
V
L
Q
S
W
C
E
K
L
A
E
Site 21
T344
Q
P
P
Q
V
L
K
T
Q
T
K
F
A
A
T
Site 22
T372
N
P
P
Q
V
K
A
T
I
I
S
E
Q
Q
A
Site 23
S375
Q
V
K
A
T
I
I
S
E
Q
Q
A
K
S
L
Site 24
S381
I
S
E
Q
Q
A
K
S
L
L
K
N
E
N
T
Site 25
T388
S
L
L
K
N
E
N
T
R
N
E
C
S
G
E
Site 26
T411
E
Y
H
Q
A
T
G
T
L
S
A
H
F
R
N
Site 27
S413
H
Q
A
T
G
T
L
S
A
H
F
R
N
M
S
Site 28
S420
S
A
H
F
R
N
M
S
L
K
R
I
K
R
A
Site 29
S434
A
D
R
R
G
A
E
S
V
T
E
E
K
F
T
Site 30
T441
S
V
T
E
E
K
F
T
V
L
F
E
S
Q
F
Site 31
S446
K
F
T
V
L
F
E
S
Q
F
S
V
G
S
N
Site 32
T481
Q
D
H
N
A
T
A
T
V
L
W
D
N
A
F
Site 33
S521
K
F
K
A
E
V
Q
S
N
R
G
L
T
K
E
Site 34
T526
V
Q
S
N
R
G
L
T
K
E
N
L
V
F
L
Site 35
S541
A
Q
K
L
F
N
N
S
S
S
H
L
E
D
Y
Site 36
S542
Q
K
L
F
N
N
S
S
S
H
L
E
D
Y
S
Site 37
S543
K
L
F
N
N
S
S
S
H
L
E
D
Y
S
G
Site 38
Y548
S
S
S
H
L
E
D
Y
S
G
L
S
V
S
W
Site 39
S549
S
S
H
L
E
D
Y
S
G
L
S
V
S
W
S
Site 40
S552
L
E
D
Y
S
G
L
S
V
S
W
S
Q
F
N
Site 41
S554
D
Y
S
G
L
S
V
S
W
S
Q
F
N
R
E
Site 42
S556
S
G
L
S
V
S
W
S
Q
F
N
R
E
N
L
Site 43
T614
L
I
N
K
P
D
G
T
F
L
L
R
F
S
D
Site 44
T647
L
W
N
L
K
P
F
T
T
R
D
F
S
I
R
Site 45
T648
W
N
L
K
P
F
T
T
R
D
F
S
I
R
S
Site 46
S652
P
F
T
T
R
D
F
S
I
R
S
L
A
D
R
Site 47
S655
T
R
D
F
S
I
R
S
L
A
D
R
L
G
D
Site 48
Y665
D
R
L
G
D
L
S
Y
L
I
Y
V
F
P
D
Site 49
Y668
G
D
L
S
Y
L
I
Y
V
F
P
D
R
P
K
Site 50
Y682
K
D
E
V
F
S
K
Y
Y
T
P
V
L
A
K
Site 51
Y683
D
E
V
F
S
K
Y
Y
T
P
V
L
A
K
A
Site 52
Y694
L
A
K
A
V
D
G
Y
V
K
P
Q
I
K
Q
Site 53
S710
V
P
E
F
V
N
A
S
A
D
A
G
G
S
S
Site 54
Y720
A
G
G
S
S
A
T
Y
M
D
Q
A
P
S
P
Site 55
S726
T
Y
M
D
Q
A
P
S
P
A
V
C
P
Q
A
Site 56
Y735
A
V
C
P
Q
A
P
Y
N
M
Y
P
Q
N
P
Site 57
Y738
P
Q
A
P
Y
N
M
Y
P
Q
N
P
D
H
V
Site 58
T757
G
E
F
D
L
D
E
T
M
D
V
A
R
H
V
Site 59
S774
L
L
R
R
P
M
D
S
L
D
S
R
L
S
P
Site 60
S777
R
P
M
D
S
L
D
S
R
L
S
P
P
A
G
Site 61
S780
D
S
L
D
S
R
L
S
P
P
A
G
L
F
T
Site 62
T787
S
P
P
A
G
L
F
T
S
A
R
G
S
L
S
Site 63
S788
P
P
A
G
L
F
T
S
A
R
G
S
L
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation