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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SKIV2L2
Full Name:
Superkiller viralicidic activity 2-like 2
Alias:
ATP-dependent helicase SKIV2L2; Dob1; FSAP118; Functional spliceosome-associated protein 118; KIAA0052; Mtr4; SK2L2
Type:
Helicase; EC 3.6.1.-; DNA binding protein
Mass (Da):
117805
Number AA:
1042
UniProt ID:
P42285
International Prot ID:
IPI00647217
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
F
G
D
E
L
F
S
V
F
E
G
D
S
T
Site 2
S17
F
S
V
F
E
G
D
S
T
T
A
A
G
T
K
Site 3
T18
S
V
F
E
G
D
S
T
T
A
A
G
T
K
K
Site 4
S40
K
W
K
G
P
P
G
S
A
D
K
A
G
K
R
Site 5
S54
R
F
D
G
K
L
Q
S
E
S
T
N
N
G
K
Site 6
S56
D
G
K
L
Q
S
E
S
T
N
N
G
K
N
K
Site 7
T71
R
D
V
D
F
E
G
T
D
E
P
I
F
G
K
Site 8
S85
K
K
P
R
I
E
E
S
I
T
E
D
L
S
L
Site 9
T87
P
R
I
E
E
S
I
T
E
D
L
S
L
A
D
Site 10
S91
E
S
I
T
E
D
L
S
L
A
D
L
M
P
R
Site 11
S103
M
P
R
V
K
V
Q
S
V
E
T
V
E
G
C
Site 12
T106
V
K
V
Q
S
V
E
T
V
E
G
C
T
H
E
Site 13
Y122
A
L
P
A
E
E
D
Y
L
P
L
K
P
R
V
Site 14
Y136
V
G
K
A
A
K
E
Y
P
F
I
L
D
A
F
Site 15
S156
Q
C
V
D
N
N
Q
S
V
L
V
S
A
H
T
Site 16
S160
N
N
Q
S
V
L
V
S
A
H
T
S
A
G
K
Site 17
S189
K
Q
R
V
I
F
T
S
P
I
K
A
L
S
N
Site 18
S195
T
S
P
I
K
A
L
S
N
Q
K
Y
R
E
M
Site 19
Y199
K
A
L
S
N
Q
K
Y
R
E
M
Y
E
E
F
Site 20
Y203
N
Q
K
Y
R
E
M
Y
E
E
F
Q
D
V
G
Site 21
S234
M
T
T
E
I
L
R
S
M
L
Y
R
G
S
E
Site 22
Y237
E
I
L
R
S
M
L
Y
R
G
S
E
V
M
R
Site 23
S240
R
S
M
L
Y
R
G
S
E
V
M
R
E
V
A
Site 24
Y256
V
I
F
D
E
I
H
Y
M
R
D
S
E
R
G
Site 25
Y308
K
Q
P
C
H
V
I
Y
T
D
Y
R
P
T
P
Site 26
Y311
C
H
V
I
Y
T
D
Y
R
P
T
P
L
Q
H
Site 27
T314
I
Y
T
D
Y
R
P
T
P
L
Q
H
Y
I
F
Site 28
Y319
R
P
T
P
L
Q
H
Y
I
F
P
A
G
G
D
Site 29
T368
Q
K
G
R
K
G
G
T
K
G
P
S
N
V
F
Site 30
S372
K
G
G
T
K
G
P
S
N
V
F
K
I
V
K
Site 31
Y402
S
K
K
D
C
E
A
Y
A
L
Q
M
T
K
L
Site 32
T407
E
A
Y
A
L
Q
M
T
K
L
D
F
N
T
D
Site 33
T413
M
T
K
L
D
F
N
T
D
E
E
K
K
M
V
Site 34
S432
S
N
A
I
D
C
L
S
D
E
D
K
K
L
P
Site 35
T466
L
L
P
I
L
K
E
T
I
E
I
L
F
S
E
Site 36
S472
E
T
I
E
I
L
F
S
E
G
L
I
K
A
L
Site 37
T499
P
A
R
T
V
L
F
T
N
A
R
K
F
D
G
Site 38
Y517
R
W
I
S
S
G
E
Y
I
Q
M
S
G
R
A
Site 39
S521
S
G
E
Y
I
Q
M
S
G
R
A
G
R
R
G
Site 40
S544
L
M
V
D
E
K
M
S
P
T
I
G
K
Q
L
Site 41
Y583
V
E
E
I
N
P
E
Y
M
L
E
K
S
F
Y
Site 42
Y590
Y
M
L
E
K
S
F
Y
Q
F
Q
H
Y
R
A
Site 43
Y595
S
F
Y
Q
F
Q
H
Y
R
A
I
P
G
V
V
Site 44
Y612
V
K
N
S
E
E
Q
Y
N
K
I
V
I
P
N
Site 45
Y626
N
E
E
S
V
V
I
Y
Y
K
I
R
Q
Q
L
Site 46
Y643
L
G
K
E
I
E
E
Y
I
H
K
P
K
Y
C
Site 47
Y649
E
Y
I
H
K
P
K
Y
C
L
P
F
L
Q
P
Site 48
S681
V
V
N
F
S
K
K
S
N
V
K
P
N
S
G
Site 49
S687
K
S
N
V
K
P
N
S
G
E
L
D
P
L
Y
Site 50
Y694
S
G
E
L
D
P
L
Y
V
V
E
V
L
L
R
Site 51
S703
V
E
V
L
L
R
C
S
K
E
S
L
K
N
S
Site 52
S706
L
L
R
C
S
K
E
S
L
K
N
S
A
T
E
Site 53
S710
S
K
E
S
L
K
N
S
A
T
E
A
A
K
P
Site 54
T712
E
S
L
K
N
S
A
T
E
A
A
K
P
A
K
Site 55
Y745
A
I
S
S
V
R
L
Y
I
P
K
D
L
R
P
Site 56
S758
R
P
V
D
N
R
Q
S
V
L
K
S
I
Q
E
Site 57
S762
N
R
Q
S
V
L
K
S
I
Q
E
V
Q
K
R
Site 58
Y805
E
A
F
E
H
R
M
Y
S
H
P
L
H
N
D
Site 59
T817
H
N
D
P
N
L
E
T
V
Y
T
L
C
E
K
Site 60
T820
P
N
L
E
T
V
Y
T
L
C
E
K
K
A
Q
Site 61
S834
Q
I
A
I
D
I
K
S
A
K
R
E
L
K
K
Site 62
S866
R
R
L
G
F
A
T
S
S
D
V
I
E
M
K
Site 63
S867
R
L
G
F
A
T
S
S
D
V
I
E
M
K
G
Site 64
S901
N
G
L
F
N
D
L
S
A
E
Q
A
T
A
L
Site 65
S946
A
K
R
I
A
K
V
S
A
E
A
K
L
E
I
Site 66
T957
K
L
E
I
D
E
E
T
Y
L
S
S
F
K
P
Site 67
Y958
L
E
I
D
E
E
T
Y
L
S
S
F
K
P
H
Site 68
S960
I
D
E
E
T
Y
L
S
S
F
K
P
H
L
M
Site 69
S961
D
E
E
T
Y
L
S
S
F
K
P
H
L
M
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation