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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKR1C3
Full Name:
Aldo-keto reductase family 1 member C3
Alias:
17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; AK1C3; AKC1H; Aldo-keto reductase family 1, member C3; Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); Chlordecone reductase homolog; Chlordecone reductase homolog HAKRb; DD3; DD-3; DDH1; DDX; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase X; EC 1.-.-.-; EC 1.1.-.-; EC 1.1.1.149; EC 1.1.1.188; EC 1.1.1.213; EC 1.1.1.62; EC 1.1.1.63; EC 1.1.1.64; EC 1.3.1.20; Estradiol 17-beta-dehydrogenase; HA1753; HAKRB; HAKRe; HluPGFS; HSD17B5; Hydroxysteroid (17-beta) dehydrogenase 5; KIAA0119; PGFS; Prostaglandin F synthase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Type II 3a-hydroxysteroid dehydrogenase variant; Type IIb 3-alpha hydroxysteroid dehydrogenase
Type:
EC 1.3.1.20; EC 1.1.1.62; EC 1.-.-.-; Lipid Metabolism - arachidonic acid; EC 1.1.1.188; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.213; EC 1.1.-.-; EC 1.1.1.149; EC 1.1.1.64; Oxidoreductase; EC 1.1.1.63
Mass (Da):
36844
Number AA:
323
UniProt ID:
P42330
International Prot ID:
IPI00291483
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0047026
GO:0004033
GO:0047718
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006693
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
P
V
L
G
F
G
T
Y
A
P
P
E
V
P
R
Site 2
S32
A
P
P
E
V
P
R
S
K
A
L
E
V
T
K
Site 3
Y55
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
Site 4
S67
Q
V
G
L
A
I
R
S
K
I
A
D
G
S
V
Site 5
S73
R
S
K
I
A
D
G
S
V
K
R
E
D
I
F
Site 6
Y81
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
T
Site 7
T82
K
R
E
D
I
F
Y
T
S
K
L
W
S
T
F
Site 8
T88
Y
T
S
K
L
W
S
T
F
H
R
P
E
L
V
Site 9
Y110
L
K
K
A
Q
L
D
Y
V
D
L
Y
L
I
H
Site 10
S121
Y
L
I
H
S
P
M
S
L
K
P
G
E
E
L
Site 11
S129
L
K
P
G
E
E
L
S
P
T
D
E
N
G
K
Site 12
T131
P
G
E
E
L
S
P
T
D
E
N
G
K
V
I
Site 13
T147
D
I
V
D
L
C
T
T
W
E
A
M
E
K
C
Site 14
S162
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
Site 15
S166
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
Site 16
Y184
L
N
K
P
G
L
K
Y
K
P
V
C
N
Q
V
Site 17
Y196
N
Q
V
E
C
H
P
Y
F
N
R
S
K
L
L
Site 18
S208
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Site 19
S221
V
A
Y
S
A
L
G
S
Q
R
D
K
R
W
V
Site 20
S232
K
R
W
V
D
P
N
S
P
V
L
L
E
D
P
Site 21
T251
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Site 22
S271
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Site 23
Y272
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
Site 24
Y305
G
L
D
R
N
L
H
Y
F
N
S
D
S
F
A
Site 25
S308
R
N
L
H
Y
F
N
S
D
S
F
A
S
H
P
Site 26
S310
L
H
Y
F
N
S
D
S
F
A
S
H
P
N
Y
Site 27
S313
F
N
S
D
S
F
A
S
H
P
N
Y
P
Y
S
Site 28
Y317
S
F
A
S
H
P
N
Y
P
Y
S
D
E
Y
_
Site 29
Y319
A
S
H
P
N
Y
P
Y
S
D
E
Y
_
_
_
Site 30
S320
S
H
P
N
Y
P
Y
S
D
E
Y
_
_
_
_
Site 31
Y323
N
Y
P
Y
S
D
E
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation