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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3CA
Full Name:
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Alias:
EC 2.7.1.153; Phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3K; PI3K p110-alpha; PI3-kinase p110 alpha; PK3CA; PtdIns-3-kinase p110
Type:
Phosphoinositide 3-kinase complex, Cytoplasm, Lamellipodium, Mitochondrion protein
Mass (Da):
124284
Number AA:
1068
UniProt ID:
P42336
International Prot ID:
IPI00031386
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0046934
PhosphoSite+
KinaseNET
Biological Process:
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
P
R
P
S
S
G
E
L
W
G
I
Site 2
S7
_
M
P
P
R
P
S
S
G
E
L
W
G
I
H
Site 3
Y56
L
F
K
E
A
R
K
Y
P
L
H
Q
L
L
Q
Site 4
S66
H
Q
L
L
Q
D
E
S
S
Y
I
F
V
S
V
Site 5
S72
E
S
S
Y
I
F
V
S
V
T
Q
E
A
E
R
Site 6
T86
R
E
E
F
F
D
E
T
R
R
L
C
D
L
R
Site 7
S158
V
D
L
R
D
L
N
S
P
H
S
R
A
M
Y
Site 8
S161
R
D
L
N
S
P
H
S
R
A
M
Y
V
Y
P
Site 9
Y165
S
P
H
S
R
A
M
Y
V
Y
P
P
N
V
E
Site 10
Y167
H
S
R
A
M
Y
V
Y
P
P
N
V
E
S
S
Site 11
S174
Y
P
P
N
V
E
S
S
P
E
L
P
K
H
I
Site 12
Y182
P
E
L
P
K
H
I
Y
N
K
L
D
K
G
Q
Site 13
Y207
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
Site 14
T229
A
E
A
I
R
K
K
T
R
S
M
L
L
S
S
Site 15
S231
A
I
R
K
K
T
R
S
M
L
L
S
S
E
Q
Site 16
S235
K
T
R
S
M
L
L
S
S
E
Q
L
K
L
C
Site 17
Y246
L
K
L
C
V
L
E
Y
Q
G
K
Y
I
L
K
Site 18
Y260
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
Site 19
Y265
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
Site 20
S268
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
Site 21
Y270
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
Site 22
Y272
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
Site 23
Y294
L
M
A
K
E
S
L
Y
S
Q
L
P
M
D
C
Site 24
S295
M
A
K
E
S
L
Y
S
Q
L
P
M
D
C
F
Site 25
T303
Q
L
P
M
D
C
F
T
M
P
S
Y
S
R
R
Site 26
Y307
D
C
F
T
M
P
S
Y
S
R
R
I
S
T
A
Site 27
S308
C
F
T
M
P
S
Y
S
R
R
I
S
T
A
T
Site 28
S312
P
S
Y
S
R
R
I
S
T
A
T
P
Y
M
N
Site 29
T313
S
Y
S
R
R
I
S
T
A
T
P
Y
M
N
G
Site 30
T315
S
R
R
I
S
T
A
T
P
Y
M
N
G
E
T
Site 31
Y317
R
I
S
T
A
T
P
Y
M
N
G
E
T
S
T
Site 32
S326
N
G
E
T
S
T
K
S
L
W
V
I
N
S
A
Site 33
Y355
I
R
D
I
D
K
I
Y
V
R
T
G
I
Y
H
Site 34
Y361
I
Y
V
R
T
G
I
Y
H
G
G
E
P
L
C
Site 35
T373
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
Site 36
Y389
R
W
N
E
W
L
N
Y
D
I
Y
I
P
D
L
Site 37
Y392
E
W
L
N
Y
D
I
Y
I
P
D
L
P
R
A
Site 38
Y432
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
Site 39
T433
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
Site 40
T435
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
Site 41
S464
N
P
I
G
V
T
G
S
N
P
N
K
E
T
P
Site 42
T470
G
S
N
P
N
K
E
T
P
C
L
E
L
E
F
Site 43
S481
E
L
E
F
D
W
F
S
S
V
V
K
F
P
D
Site 44
S490
V
V
K
F
P
D
M
S
V
I
E
E
H
A
N
Site 45
S499
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
Site 46
S501
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
Site 47
S507
V
S
R
E
A
G
F
S
Y
S
H
A
G
L
S
Site 48
Y508
S
R
E
A
G
F
S
Y
S
H
A
G
L
S
N
Site 49
S509
R
E
A
G
F
S
Y
S
H
A
G
L
S
N
R
Site 50
S514
S
Y
S
H
A
G
L
S
N
R
L
A
R
D
N
Site 51
S535
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
Site 52
T536
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
I
Site 53
S541
I
S
T
R
D
P
L
S
E
I
T
E
Q
E
K
Site 54
T560
S
H
R
H
Y
C
V
T
I
P
E
I
L
P
K
Site 55
S571
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
Site 56
Y584
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
Site 57
Y606
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
Site 58
Y622
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Site 59
T624
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
Site 60
Y631
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
Site 61
Y641
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
Site 62
Y644
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
Site 63
T659
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
Site 64
T679
K
S
E
M
H
N
K
T
V
S
Q
R
F
G
L
Site 65
S681
E
M
H
N
K
T
V
S
Q
R
F
G
L
L
L
Site 66
Y698
Y
C
R
A
C
G
M
Y
L
K
H
L
N
R
Q
Site 67
T727
K
Q
E
K
K
D
E
T
Q
K
V
Q
M
K
F
Site 68
S753
D
A
L
Q
G
F
L
S
P
L
N
P
A
H
Q
Site 69
S773
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
Site 70
S774
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
Site 71
S874
K
G
A
L
Q
F
N
S
H
T
L
H
Q
W
L
Site 72
T876
A
L
Q
F
N
S
H
T
L
H
Q
W
L
K
D
Site 73
Y890
D
K
N
K
G
E
I
Y
D
A
A
I
D
L
F
Site 74
S919
G
I
G
D
R
H
N
S
N
I
M
V
K
D
D
Site 75
Y947
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
Site 76
T974
G
A
Q
E
C
T
K
T
R
E
F
E
R
F
Q
Site 77
Y988
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
Site 78
S1015
S
G
M
P
E
L
Q
S
F
D
D
I
A
Y
I
Site 79
Y1021
Q
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
Site 80
T1025
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Site 81
T1031
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
Site 82
Y1038
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation