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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3CB
Full Name:
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Alias:
EC 2.7.1.153; P11B; Phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3K; PI3K p110-beta; PI3Kbeta; PI3-kinase p110 subunit beta; PIK3C1; PK3CB; PtdIns-3-kinase p110
Type:
EC 2.7.1.153; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate
Mass (Da):
122762
Number AA:
1070
UniProt ID:
P42338
International Prot ID:
IPI00031388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005942
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0046934
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0000187
GO:0006935
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
D
I
W
A
V
D
S
Q
I
A
S
D
G
S
Site 2
S26
A
V
D
S
Q
I
A
S
D
G
S
I
P
V
D
Site 3
T51
L
E
V
P
R
E
A
T
I
S
Y
I
K
Q
M
Site 4
Y54
P
R
E
A
T
I
S
Y
I
K
Q
M
L
W
K
Site 5
S115
V
L
K
L
V
T
R
S
C
D
P
G
E
K
L
Site 6
S124
D
P
G
E
K
L
D
S
K
I
G
V
L
I
G
Site 7
S139
K
G
L
H
E
F
D
S
L
K
D
P
E
V
N
Site 8
S156
R
R
K
M
R
K
F
S
E
E
K
I
L
S
L
Site 9
Y176
M
D
W
L
K
Q
T
Y
P
P
E
H
E
P
S
Site 10
S183
Y
P
P
E
H
E
P
S
I
P
E
N
L
E
D
Site 11
Y193
E
N
L
E
D
K
L
Y
G
G
K
L
I
V
A
Site 12
S215
D
V
F
S
F
Q
V
S
P
N
M
N
P
I
K
Site 13
T233
L
A
I
Q
K
R
L
T
I
H
G
K
E
D
E
Site 14
S242
H
G
K
E
D
E
V
S
P
Y
D
Y
V
L
Q
Site 15
Y244
K
E
D
E
V
S
P
Y
D
Y
V
L
Q
V
S
Site 16
Y246
D
E
V
S
P
Y
D
Y
V
L
Q
V
S
G
R
Site 17
Y256
Q
V
S
G
R
V
E
Y
V
F
G
D
H
P
L
Site 18
S308
E
A
A
I
N
R
N
S
S
N
L
P
L
P
L
Site 19
S309
A
A
I
N
R
N
S
S
N
L
P
L
P
L
P
Site 20
T320
L
P
L
P
P
K
K
T
R
I
I
S
H
V
W
Site 21
T348
N
K
L
N
T
E
E
T
V
K
V
H
V
R
A
Site 22
S371
L
C
K
T
I
V
S
S
E
V
S
G
K
N
D
Site 23
S374
T
I
V
S
S
E
V
S
G
K
N
D
H
I
W
Site 24
T413
A
V
L
D
K
V
K
T
K
K
S
T
K
T
I
Site 25
S416
D
K
V
K
T
K
K
S
T
K
T
I
N
P
S
Site 26
T417
K
V
K
T
K
K
S
T
K
T
I
N
P
S
K
Site 27
T419
K
T
K
K
S
T
K
T
I
N
P
S
K
Y
Q
Site 28
S423
S
T
K
T
I
N
P
S
K
Y
Q
T
I
R
K
Site 29
Y425
K
T
I
N
P
S
K
Y
Q
T
I
R
K
A
G
Site 30
T427
I
N
P
S
K
Y
Q
T
I
R
K
A
G
K
V
Site 31
Y436
R
K
A
G
K
V
H
Y
P
V
A
W
V
N
T
Site 32
S461
T
G
D
I
I
L
H
S
W
S
S
F
P
D
E
Site 33
S463
D
I
I
L
H
S
W
S
S
F
P
D
E
L
E
Site 34
S464
I
I
L
H
S
W
S
S
F
P
D
E
L
E
E
Site 35
T478
E
M
L
N
P
M
G
T
V
Q
T
N
P
Y
T
Site 36
Y503
P
E
N
K
K
Q
P
Y
Y
Y
P
P
F
D
K
Site 37
Y504
E
N
K
K
Q
P
Y
Y
Y
P
P
F
D
K
I
Site 38
Y505
N
K
K
Q
P
Y
Y
Y
P
P
F
D
K
I
I
Site 39
S521
K
A
A
E
I
A
S
S
D
S
A
N
V
S
S
Site 40
S523
A
E
I
A
S
S
D
S
A
N
V
S
S
R
G
Site 41
S527
S
S
D
S
A
N
V
S
S
R
G
G
K
K
F
Site 42
S548
I
L
D
R
D
P
L
S
Q
L
C
E
N
E
M
Site 43
S579
S
L
P
K
L
L
L
S
I
K
W
N
K
L
E
Site 44
Y614
L
E
L
L
D
F
N
Y
P
D
Q
Y
V
R
E
Site 45
Y618
D
F
N
Y
P
D
Q
Y
V
R
E
Y
A
V
G
Site 46
Y622
P
D
Q
Y
V
R
E
Y
A
V
G
C
L
R
Q
Site 47
S631
V
G
C
L
R
Q
M
S
D
E
E
L
S
Q
Y
Site 48
S636
Q
M
S
D
E
E
L
S
Q
Y
L
L
Q
L
V
Site 49
Y638
S
D
E
E
L
S
Q
Y
L
L
Q
L
V
Q
V
Site 50
T721
E
A
L
N
K
L
K
T
L
N
S
L
I
K
L
Site 51
S724
N
K
L
K
T
L
N
S
L
I
K
L
N
A
V
Site 52
T744
K
G
K
E
A
M
H
T
C
L
K
Q
S
A
Y
Site 53
S749
M
H
T
C
L
K
Q
S
A
Y
R
E
A
L
S
Site 54
S756
S
A
Y
R
E
A
L
S
D
L
Q
S
P
L
N
Site 55
Y772
C
V
I
L
S
E
L
Y
V
E
K
C
K
Y
M
Site 56
Y778
L
Y
V
E
K
C
K
Y
M
D
S
K
M
K
P
Site 57
S799
N
K
V
F
G
E
D
S
V
G
V
I
F
K
N
Site 58
S890
N
W
L
K
E
Y
N
S
G
D
D
L
D
R
A
Site 59
S922
L
G
I
G
D
R
H
S
D
N
I
M
V
K
K
Site 60
S947
H
I
L
G
N
F
K
S
K
F
G
I
K
R
E
Site 61
T961
E
R
V
P
F
I
L
T
Y
D
F
I
H
V
I
Site 62
Y962
R
V
P
F
I
L
T
Y
D
F
I
H
V
I
Q
Site 63
Y990
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
Site 64
Y1023
T
S
V
K
D
I
Q
Y
L
K
D
S
L
A
L
Site 65
S1027
D
I
Q
Y
L
K
D
S
L
A
L
G
K
S
E
Site 66
S1033
D
S
L
A
L
G
K
S
E
E
E
A
L
K
Q
Site 67
S1070
T
V
R
K
D
Y
R
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation