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Updated November 2019
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Protein Info
Short Name:
PI4KA
Full Name:
Phosphatidylinositol 4-kinase alpha
Alias:
EC 2.7.1.67; Phosphatidylinositol 4-kinase 230; Pi4K230; PI4K-alpha; PI4-kinase; PI4-kinase alpha; PIK4; PtdIns-4-kinase
Type:
Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid
Mass (Da):
231319
Number AA:
2044
UniProt ID:
P42356
International Prot ID:
IPI00070943
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005798
Uniprot
OncoNet
Molecular Function:
GO:0004430
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006661
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S58
K
V
Y
W
V
E
E
S
T
A
R
K
G
R
G
Site 2
Y86
T
L
L
S
D
V
A
Y
R
D
P
S
L
R
D
Site 3
S90
D
V
A
Y
R
D
P
S
L
R
D
E
I
L
E
Site 4
Y120
L
E
I
Q
D
K
E
Y
L
C
K
Y
A
I
P
Site 5
Y139
I
S
R
A
F
G
R
Y
S
N
M
E
E
S
L
Site 6
S140
S
R
A
F
G
R
Y
S
N
M
E
E
S
L
L
Site 7
S145
R
Y
S
N
M
E
E
S
L
L
S
K
L
F
P
Site 8
S148
N
M
E
E
S
L
L
S
K
L
F
P
K
I
P
Site 9
S158
F
P
K
I
P
P
H
S
L
R
V
L
E
E
L
Site 10
S172
L
E
G
V
R
R
R
S
F
N
D
F
R
S
I
Site 11
S178
R
S
F
N
D
F
R
S
I
L
P
S
N
L
L
Site 12
S182
D
F
R
S
I
L
P
S
N
L
L
T
V
C
Q
Site 13
T192
L
T
V
C
Q
E
G
T
L
K
R
K
T
S
S
Site 14
T197
E
G
T
L
K
R
K
T
S
S
V
S
S
I
S
Site 15
S198
G
T
L
K
R
K
T
S
S
V
S
S
I
S
Q
Site 16
S199
T
L
K
R
K
T
S
S
V
S
S
I
S
Q
V
Site 17
S201
K
R
K
T
S
S
V
S
S
I
S
Q
V
S
P
Site 18
S202
R
K
T
S
S
V
S
S
I
S
Q
V
S
P
E
Site 19
S204
T
S
S
V
S
S
I
S
Q
V
S
P
E
R
G
Site 20
S207
V
S
S
I
S
Q
V
S
P
E
R
G
M
P
P
Site 21
S216
E
R
G
M
P
P
P
S
S
P
G
G
S
A
F
Site 22
S217
R
G
M
P
P
P
S
S
P
G
G
S
A
F
H
Site 23
S221
P
P
S
S
P
G
G
S
A
F
H
Y
F
E
A
Site 24
Y225
P
G
G
S
A
F
H
Y
F
E
A
S
C
L
P
Site 25
Y241
G
T
A
L
E
P
E
Y
Y
F
S
T
I
S
S
Site 26
Y242
T
A
L
E
P
E
Y
Y
F
S
T
I
S
S
S
Site 27
S244
L
E
P
E
Y
Y
F
S
T
I
S
S
S
F
S
Site 28
T245
E
P
E
Y
Y
F
S
T
I
S
S
S
F
S
V
Site 29
S247
E
Y
Y
F
S
T
I
S
S
S
F
S
V
S
P
Site 30
T260
S
P
L
F
N
G
V
T
Y
K
E
F
N
I
P
Site 31
S303
S
V
M
E
A
N
P
S
A
D
L
Y
Y
T
S
Site 32
Y307
A
N
P
S
A
D
L
Y
Y
T
S
F
S
D
P
Site 33
Y308
N
P
S
A
D
L
Y
Y
T
S
F
S
D
P
L
Site 34
T309
P
S
A
D
L
Y
Y
T
S
F
S
D
P
L
Y
Site 35
S310
S
A
D
L
Y
Y
T
S
F
S
D
P
L
Y
L
Site 36
S312
D
L
Y
Y
T
S
F
S
D
P
L
Y
L
T
M
Site 37
T318
F
S
D
P
L
Y
L
T
M
F
K
M
L
R
D
Site 38
Y328
K
M
L
R
D
T
L
Y
Y
M
K
D
L
P
T
Site 39
Y329
M
L
R
D
T
L
Y
Y
M
K
D
L
P
T
S
Site 40
S336
Y
M
K
D
L
P
T
S
F
V
K
E
I
H
D
Site 41
T351
F
V
L
E
Q
F
N
T
S
Q
G
E
L
Q
K
Site 42
S371
D
R
I
H
N
E
L
S
P
L
K
L
R
C
Q
Site 43
S405
E
N
L
C
I
K
L
S
E
K
L
Q
S
K
T
Site 44
S410
K
L
S
E
K
L
Q
S
K
T
S
S
K
V
I
Site 45
S413
E
K
L
Q
S
K
T
S
S
K
V
I
I
A
H
Site 46
S414
K
L
Q
S
K
T
S
S
K
V
I
I
A
H
L
Site 47
S444
R
F
P
V
V
V
H
S
V
T
P
S
L
R
D
Site 48
T446
P
V
V
V
H
S
V
T
P
S
L
R
D
F
L
Site 49
S448
V
V
H
S
V
T
P
S
L
R
D
F
L
V
I
Site 50
Y464
S
P
V
L
V
K
L
Y
K
Y
H
S
Q
Y
H
Site 51
Y466
V
L
V
K
L
Y
K
Y
H
S
Q
Y
H
T
V
Site 52
S468
V
K
L
Y
K
Y
H
S
Q
Y
H
T
V
A
G
Site 53
Y470
L
Y
K
Y
H
S
Q
Y
H
T
V
A
G
N
D
Site 54
T472
K
Y
H
S
Q
Y
H
T
V
A
G
N
D
I
K
Site 55
S481
A
G
N
D
I
K
I
S
V
T
N
E
H
S
E
Site 56
T483
N
D
I
K
I
S
V
T
N
E
H
S
E
S
T
Site 57
S489
V
T
N
E
H
S
E
S
T
L
N
V
M
S
G
Site 58
S495
E
S
T
L
N
V
M
S
G
K
K
S
Q
P
S
Site 59
S499
N
V
M
S
G
K
K
S
Q
P
S
M
Y
E
Q
Site 60
S502
S
G
K
K
S
Q
P
S
M
Y
E
Q
L
R
D
Site 61
Y542
A
S
L
S
N
R
L
Y
I
S
Q
E
S
D
K
Site 62
S544
L
S
N
R
L
Y
I
S
Q
E
S
D
K
D
A
Site 63
T608
Q
L
G
C
L
V
I
T
G
N
Q
Y
I
Y
Q
Site 64
Y612
L
V
I
T
G
N
Q
Y
I
Y
Q
E
V
W
N
Site 65
Y614
I
T
G
N
Q
Y
I
Y
Q
E
V
W
N
L
F
Site 66
Y633
V
K
A
S
S
V
V
Y
S
A
T
K
D
Y
K
Site 67
S634
K
A
S
S
V
V
Y
S
A
T
K
D
Y
K
D
Site 68
Y639
V
Y
S
A
T
K
D
Y
K
D
H
G
Y
R
H
Site 69
Y644
K
D
Y
K
D
H
G
Y
R
H
C
S
L
A
V
Site 70
S690
G
L
E
G
K
R
A
S
E
R
A
S
E
K
G
Site 71
S694
K
R
A
S
E
R
A
S
E
K
G
P
A
L
K
Site 72
S703
K
G
P
A
L
K
A
S
S
S
A
G
N
L
G
Site 73
S705
P
A
L
K
A
S
S
S
A
G
N
L
G
V
L
Site 74
Y762
G
L
W
P
E
E
W
Y
E
G
V
C
E
I
A
Site 75
T776
A
T
K
S
P
L
L
T
F
P
S
K
E
P
L
Site 76
S779
S
P
L
L
T
F
P
S
K
E
P
L
R
S
V
Site 77
S785
P
S
K
E
P
L
R
S
V
L
Q
Y
N
S
A
Site 78
Y789
P
L
R
S
V
L
Q
Y
N
S
A
M
K
N
D
Site 79
T797
N
S
A
M
K
N
D
T
V
T
P
A
E
L
S
Site 80
T799
A
M
K
N
D
T
V
T
P
A
E
L
S
E
L
Site 81
T809
E
L
S
E
L
R
S
T
I
I
N
L
L
D
P
Site 82
Y843
L
S
V
Y
R
L
E
Y
M
R
V
L
R
S
T
Site 83
S849
E
Y
M
R
V
L
R
S
T
D
P
D
R
F
Q
Site 84
T850
Y
M
R
V
L
R
S
T
D
P
D
R
F
Q
V
Site 85
Y861
R
F
Q
V
M
F
C
Y
F
E
D
K
A
I
Q
Site 86
Y931
I
R
R
V
A
D
K
Y
L
S
G
L
V
D
K
Site 87
S964
Q
T
L
S
L
S
L
S
A
D
I
H
K
D
Q
Site 88
Y973
D
I
H
K
D
Q
P
Y
Y
D
I
P
D
A
P
Site 89
Y974
I
H
K
D
Q
P
Y
Y
D
I
P
D
A
P
Y
Site 90
Y981
Y
D
I
P
D
A
P
Y
R
I
T
V
P
D
T
Site 91
T984
P
D
A
P
Y
R
I
T
V
P
D
T
Y
E
A
Site 92
T988
Y
R
I
T
V
P
D
T
Y
E
A
R
E
S
I
Site 93
Y989
R
I
T
V
P
D
T
Y
E
A
R
E
S
I
V
Site 94
S994
D
T
Y
E
A
R
E
S
I
V
K
D
F
A
A
Site 95
T1016
E
A
M
K
W
A
P
T
V
T
K
S
H
L
Q
Site 96
Y1025
T
K
S
H
L
Q
E
Y
L
N
K
H
Q
N
W
Site 97
S1037
Q
N
W
V
S
G
L
S
Q
H
T
G
L
A
M
Site 98
Y1055
S
I
L
H
F
A
G
Y
N
K
Q
N
T
T
L
Site 99
S1068
T
L
G
A
T
Q
L
S
E
R
P
A
C
V
K
Site 100
Y1078
P
A
C
V
K
K
D
Y
S
N
F
M
A
S
L
Site 101
Y1091
S
L
N
L
R
N
R
Y
A
G
E
V
Y
G
M
Site 102
Y1096
N
R
Y
A
G
E
V
Y
G
M
I
R
F
S
G
Site 103
S1102
V
Y
G
M
I
R
F
S
G
T
T
G
Q
M
S
Site 104
T1105
M
I
R
F
S
G
T
T
G
Q
M
S
D
L
N
Site 105
S1109
S
G
T
T
G
Q
M
S
D
L
N
K
M
M
V
Site 106
S1121
M
M
V
Q
D
L
H
S
A
L
D
R
S
H
P
Site 107
T1132
R
S
H
P
Q
H
Y
T
Q
A
M
F
K
L
T
Site 108
S1222
E
A
D
P
L
A
A
S
E
A
S
Q
P
K
P
Site 109
Y1253
Q
R
F
E
I
A
K
Y
C
S
S
D
Q
V
E
Site 110
S1256
E
I
A
K
Y
C
S
S
D
Q
V
E
I
F
S
Site 111
S1264
D
Q
V
E
I
F
S
S
L
L
Q
R
S
M
S
Site 112
S1271
S
L
L
Q
R
S
M
S
L
N
I
G
G
A
K
Site 113
S1280
N
I
G
G
A
K
G
S
M
N
R
H
V
A
A
Site 114
Y1321
N
V
L
R
E
K
I
Y
S
T
A
F
D
Y
F
Site 115
S1322
V
L
R
E
K
I
Y
S
T
A
F
D
Y
F
S
Site 116
Y1327
I
Y
S
T
A
F
D
Y
F
S
C
P
P
K
F
Site 117
S1329
S
T
A
F
D
Y
F
S
C
P
P
K
F
P
T
Site 118
Y1362
A
M
F
S
D
K
K
Y
L
T
A
S
Q
L
V
Site 119
T1364
F
S
D
K
K
Y
L
T
A
S
Q
L
V
P
P
Site 120
S1366
D
K
K
Y
L
T
A
S
Q
L
V
P
P
D
N
Site 121
S1378
P
D
N
Q
D
T
R
S
N
L
D
I
T
V
G
Site 122
T1383
T
R
S
N
L
D
I
T
V
G
S
R
Q
Q
A
Site 123
T1397
A
T
Q
G
W
I
N
T
Y
P
L
S
S
G
M
Site 124
Y1398
T
Q
G
W
I
N
T
Y
P
L
S
S
G
M
S
Site 125
S1401
W
I
N
T
Y
P
L
S
S
G
M
S
T
I
S
Site 126
S1402
I
N
T
Y
P
L
S
S
G
M
S
T
I
S
K
Site 127
S1405
Y
P
L
S
S
G
M
S
T
I
S
K
K
S
G
Site 128
T1406
P
L
S
S
G
M
S
T
I
S
K
K
S
G
M
Site 129
S1408
S
S
G
M
S
T
I
S
K
K
S
G
M
S
K
Site 130
S1411
M
S
T
I
S
K
K
S
G
M
S
K
K
T
N
Site 131
T1417
K
S
G
M
S
K
K
T
N
R
G
S
Q
L
H
Site 132
S1421
S
K
K
T
N
R
G
S
Q
L
H
K
Y
Y
M
Site 133
Y1426
R
G
S
Q
L
H
K
Y
Y
M
K
R
R
T
L
Site 134
Y1427
G
S
Q
L
H
K
Y
Y
M
K
R
R
T
L
L
Site 135
T1447
T
E
I
E
R
L
I
T
W
Y
N
P
L
S
A
Site 136
Y1449
I
E
R
L
I
T
W
Y
N
P
L
S
A
P
E
Site 137
S1453
I
T
W
Y
N
P
L
S
A
P
E
L
E
L
D
Site 138
S1466
L
D
Q
A
G
E
N
S
V
A
N
W
R
S
K
Site 139
S1472
N
S
V
A
N
W
R
S
K
Y
I
S
L
S
E
Site 140
Y1474
V
A
N
W
R
S
K
Y
I
S
L
S
E
K
Q
Site 141
S1476
N
W
R
S
K
Y
I
S
L
S
E
K
Q
W
K
Site 142
S1478
R
S
K
Y
I
S
L
S
E
K
Q
W
K
D
N
Site 143
S1526
R
L
D
P
G
A
V
S
D
V
P
E
A
I
K
Site 144
S1549
D
A
D
A
P
E
L
S
H
V
L
C
W
A
P
Site 145
T1557
H
V
L
C
W
A
P
T
D
P
P
T
G
L
S
Site 146
T1561
W
A
P
T
D
P
P
T
G
L
S
Y
F
S
S
Site 147
S1564
T
D
P
P
T
G
L
S
Y
F
S
S
M
Y
P
Site 148
Y1565
D
P
P
T
G
L
S
Y
F
S
S
M
Y
P
P
Site 149
S1568
T
G
L
S
Y
F
S
S
M
Y
P
P
H
P
L
Site 150
Y1570
L
S
Y
F
S
S
M
Y
P
P
H
P
L
T
A
Site 151
T1576
M
Y
P
P
H
P
L
T
A
Q
Y
G
V
K
V
Site 152
Y1605
Q
I
V
Q
A
L
R
Y
D
K
M
G
Y
V
R
Site 153
Y1610
L
R
Y
D
K
M
G
Y
V
R
E
Y
I
L
W
Site 154
Y1614
K
M
G
Y
V
R
E
Y
I
L
W
A
A
S
K
Site 155
Y1638
W
N
M
K
T
N
I
Y
L
D
E
E
G
H
Q
Site 156
T1662
D
Q
L
V
E
E
I
T
G
S
L
S
G
P
A
Site 157
S1664
L
V
E
E
I
T
G
S
L
S
G
P
A
K
D
Site 158
S1666
E
E
I
T
G
S
L
S
G
P
A
K
D
F
Y
Site 159
Y1673
S
G
P
A
K
D
F
Y
Q
R
E
F
D
F
F
Site 160
Y1693
V
S
A
I
I
K
P
Y
P
K
G
D
E
R
K
Site 161
S1705
E
R
K
K
A
C
L
S
A
L
S
E
V
K
V
Site 162
Y1717
V
K
V
Q
P
G
C
Y
L
P
S
N
P
E
A
Site 163
S1733
V
L
D
I
D
Y
K
S
G
T
P
M
Q
S
A
Site 164
T1735
D
I
D
Y
K
S
G
T
P
M
Q
S
A
A
K
Site 165
S1739
K
S
G
T
P
M
Q
S
A
A
K
A
P
Y
L
Site 166
Y1745
Q
S
A
A
K
A
P
Y
L
A
K
F
K
V
K
Site 167
S1768
K
E
G
L
R
C
R
S
D
S
E
D
E
C
S
Site 168
S1770
G
L
R
C
R
S
D
S
E
D
E
C
S
T
Q
Site 169
S1775
S
D
S
E
D
E
C
S
T
Q
E
A
D
G
Q
Site 170
S1785
E
A
D
G
Q
K
I
S
W
Q
A
A
I
F
K
Site 171
Y1826
L
D
L
F
V
F
P
Y
R
V
V
A
T
A
P
Site 172
T1845
I
E
C
I
P
D
C
T
S
R
D
Q
L
G
R
Site 173
S1846
E
C
I
P
D
C
T
S
R
D
Q
L
G
R
Q
Site 174
T1854
R
D
Q
L
G
R
Q
T
D
F
G
M
Y
D
Y
Site 175
Y1859
R
Q
T
D
F
G
M
Y
D
Y
F
T
R
Q
Y
Site 176
Y1861
T
D
F
G
M
Y
D
Y
F
T
R
Q
Y
G
D
Site 177
Y1866
Y
D
Y
F
T
R
Q
Y
G
D
E
S
T
L
A
Site 178
T1871
R
Q
Y
G
D
E
S
T
L
A
F
Q
Q
A
R
Site 179
S1924
D
F
G
F
M
F
E
S
S
P
G
G
N
L
G
Site 180
S1925
F
G
F
M
F
E
S
S
P
G
G
N
L
G
W
Site 181
T1995
L
P
C
F
R
G
Q
T
I
K
L
L
K
H
R
Site 182
S2004
K
L
L
K
H
R
F
S
P
N
M
T
E
R
E
Site 183
T2008
H
R
F
S
P
N
M
T
E
R
E
A
A
N
F
Site 184
S2026
V
I
Q
S
C
F
L
S
N
R
S
R
T
Y
D
Site 185
T2031
F
L
S
N
R
S
R
T
Y
D
M
I
Q
Y
Y
Site 186
Y2032
L
S
N
R
S
R
T
Y
D
M
I
Q
Y
Y
Q
Site 187
Y2037
R
T
Y
D
M
I
Q
Y
Y
Q
N
D
I
P
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation