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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPS15
Full Name:
Epidermal growth factor receptor substrate 15
Alias:
AF1P; AF-1p protein; EP15; Epidermal growth factor receptor pathway substrate 15 (AF1p)
Type:
Adapter/scaffold protein, endocytosis vesicle protein; Receptor internalization protein; Coated pit, endosome, early endosome membrane, cytoplasm, plasma membrane
Mass (Da):
98656
Number AA:
896
UniProt ID:
P42566
International Prot ID:
IPI00292134
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005905
GO:0005829
GO:0005768
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007173
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
A
A
A
Q
L
S
L
T
Q
L
S
S
G
N
P
Site 2
S14
L
S
L
T
Q
L
S
S
G
N
P
V
Y
E
K
Site 3
Y19
L
S
S
G
N
P
V
Y
E
K
Y
Y
R
Q
V
Site 4
Y22
G
N
P
V
Y
E
K
Y
Y
R
Q
V
D
T
G
Site 5
Y23
N
P
V
Y
E
K
Y
Y
R
Q
V
D
T
G
N
Site 6
T62
K
I
W
D
L
A
D
T
D
G
K
G
I
L
N
Site 7
T106
P
P
P
R
F
H
D
T
S
S
P
L
L
I
S
Site 8
S107
P
P
R
F
H
D
T
S
S
P
L
L
I
S
G
Site 9
S108
P
R
F
H
D
T
S
S
P
L
L
I
S
G
T
Site 10
S116
P
L
L
I
S
G
T
S
A
A
E
L
P
W
A
Site 11
Y132
K
P
E
D
K
A
K
Y
D
A
I
F
D
S
L
Site 12
S138
K
Y
D
A
I
F
D
S
L
S
P
V
N
G
F
Site 13
S140
D
A
I
F
D
S
L
S
P
V
N
G
F
L
S
Site 14
S147
S
P
V
N
G
F
L
S
G
D
K
V
K
P
V
Site 15
S172
L
G
R
V
W
E
L
S
D
I
D
H
D
G
M
Site 16
S204
E
K
E
P
V
P
M
S
L
P
P
A
L
V
P
Site 17
S213
P
P
A
L
V
P
P
S
K
R
K
T
W
V
V
Site 18
T217
V
P
P
S
K
R
K
T
W
V
V
S
P
A
E
Site 19
S221
K
R
K
T
W
V
V
S
P
A
E
K
A
K
Y
Site 20
Y228
S
P
A
E
K
A
K
Y
D
E
I
F
L
K
T
Site 21
T304
I
D
P
P
H
V
L
T
P
E
M
I
P
P
S
Site 22
S311
T
P
E
M
I
P
P
S
D
R
A
S
L
Q
K
Site 23
S315
I
P
P
S
D
R
A
S
L
Q
K
N
I
I
G
Site 24
S323
L
Q
K
N
I
I
G
S
S
P
V
A
D
F
S
Site 25
S324
Q
K
N
I
I
G
S
S
P
V
A
D
F
S
A
Site 26
S330
S
S
P
V
A
D
F
S
A
I
K
E
L
D
T
Site 27
T337
S
A
I
K
E
L
D
T
L
N
N
E
I
V
D
Site 28
T362
D
L
K
E
K
E
D
T
I
K
Q
R
T
S
E
Site 29
S368
D
T
I
K
Q
R
T
S
E
V
Q
D
L
Q
D
Site 30
T382
D
E
V
Q
R
E
N
T
N
L
Q
K
L
Q
A
Site 31
S428
E
E
A
Q
L
I
S
S
L
K
A
E
L
T
S
Site 32
T434
S
S
L
K
A
E
L
T
S
Q
E
S
Q
I
S
Site 33
S435
S
L
K
A
E
L
T
S
Q
E
S
Q
I
S
T
Site 34
S438
A
E
L
T
S
Q
E
S
Q
I
S
T
Y
E
E
Site 35
S441
T
S
Q
E
S
Q
I
S
T
Y
E
E
E
L
A
Site 36
T442
S
Q
E
S
Q
I
S
T
Y
E
E
E
L
A
K
Site 37
Y443
Q
E
S
Q
I
S
T
Y
E
E
E
L
A
K
A
Site 38
T461
L
S
R
L
Q
Q
E
T
A
E
L
E
E
S
V
Site 39
S467
E
T
A
E
L
E
E
S
V
E
S
G
K
A
Q
Site 40
S470
E
L
E
E
S
V
E
S
G
K
A
Q
L
E
P
Site 41
S485
L
Q
Q
H
L
Q
D
S
Q
Q
E
I
S
S
M
Site 42
S491
D
S
Q
Q
E
I
S
S
M
Q
M
K
L
M
E
Site 43
S507
K
D
L
E
N
H
N
S
Q
L
N
W
C
S
S
Site 44
S513
N
S
Q
L
N
W
C
S
S
P
H
S
I
L
V
Site 45
S514
S
Q
L
N
W
C
S
S
P
H
S
I
L
V
N
Site 46
Y526
L
V
N
G
A
T
D
Y
C
S
L
S
T
S
S
Site 47
S528
N
G
A
T
D
Y
C
S
L
S
T
S
S
S
E
Site 48
S530
A
T
D
Y
C
S
L
S
T
S
S
S
E
T
A
Site 49
S532
D
Y
C
S
L
S
T
S
S
S
E
T
A
N
L
Site 50
S534
C
S
L
S
T
S
S
S
E
T
A
N
L
N
E
Site 51
T536
L
S
T
S
S
S
E
T
A
N
L
N
E
H
V
Site 52
S551
E
G
Q
S
N
L
E
S
E
P
I
H
Q
E
S
Site 53
S558
S
E
P
I
H
Q
E
S
P
A
R
S
S
P
E
Site 54
S562
H
Q
E
S
P
A
R
S
S
P
E
L
L
P
S
Site 55
S563
Q
E
S
P
A
R
S
S
P
E
L
L
P
S
G
Site 56
S569
S
S
P
E
L
L
P
S
G
V
T
D
E
N
E
Site 57
T578
V
T
D
E
N
E
V
T
T
A
V
T
E
K
V
Site 58
S595
E
L
D
N
N
R
H
S
K
E
E
D
P
F
N
Site 59
S605
E
D
P
F
N
V
D
S
S
S
L
T
G
P
V
Site 60
S607
P
F
N
V
D
S
S
S
L
T
G
P
V
A
D
Site 61
T609
N
V
D
S
S
S
L
T
G
P
V
A
D
T
N
Site 62
T615
L
T
G
P
V
A
D
T
N
L
D
F
F
Q
S
Site 63
S622
T
N
L
D
F
F
Q
S
D
P
F
V
G
S
D
Site 64
S628
Q
S
D
P
F
V
G
S
D
P
F
K
D
D
P
Site 65
S650
G
G
D
P
F
K
G
S
D
P
F
A
S
D
C
Site 66
S655
K
G
S
D
P
F
A
S
D
C
F
F
R
Q
S
Site 67
S662
S
D
C
F
F
R
Q
S
T
D
P
F
A
T
S
Site 68
T663
D
C
F
F
R
Q
S
T
D
P
F
A
T
S
S
Site 69
S669
S
T
D
P
F
A
T
S
S
T
D
P
F
S
A
Site 70
S670
T
D
P
F
A
T
S
S
T
D
P
F
S
A
A
Site 71
T671
D
P
F
A
T
S
S
T
D
P
F
S
A
A
N
Site 72
S675
T
S
S
T
D
P
F
S
A
A
N
N
S
S
I
Site 73
S680
P
F
S
A
A
N
N
S
S
I
T
S
V
E
T
Site 74
S684
A
N
N
S
S
I
T
S
V
E
T
L
K
H
N
Site 75
S713
S
A
T
D
P
F
A
S
V
F
G
N
E
S
F
Site 76
S728
G
G
G
F
A
D
F
S
T
L
S
K
V
N
N
Site 77
T729
G
G
F
A
D
F
S
T
L
S
K
V
N
N
E
Site 78
S741
N
N
E
D
P
F
R
S
A
T
S
S
S
V
S
Site 79
T743
E
D
P
F
R
S
A
T
S
S
S
V
S
N
V
Site 80
S744
D
P
F
R
S
A
T
S
S
S
V
S
N
V
V
Site 81
S748
S
A
T
S
S
S
V
S
N
V
V
I
T
K
N
Site 82
S764
F
E
E
T
S
V
K
S
E
D
E
P
P
A
L
Site 83
T777
A
L
P
P
K
I
G
T
P
T
R
P
C
P
L
Site 84
T779
P
P
K
I
G
T
P
T
R
P
C
P
L
P
P
Site 85
S790
P
L
P
P
G
K
R
S
I
N
K
L
D
S
P
Site 86
S796
R
S
I
N
K
L
D
S
P
D
P
F
K
L
N
Site 87
S814
Q
P
F
P
G
N
D
S
P
K
E
K
D
P
E
Site 88
T828
E
I
F
C
D
P
F
T
S
A
T
T
T
T
N
Site 89
T833
P
F
T
S
A
T
T
T
T
N
K
E
A
D
P
Site 90
S841
T
N
K
E
A
D
P
S
N
F
A
N
F
S
A
Site 91
S847
P
S
N
F
A
N
F
S
A
Y
P
S
E
E
D
Site 92
Y849
N
F
A
N
F
S
A
Y
P
S
E
E
D
M
I
Site 93
S851
A
N
F
S
A
Y
P
S
E
E
D
M
I
E
W
Site 94
S863
I
E
W
A
K
R
E
S
E
R
E
E
E
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation