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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASP3
Full Name:
Caspase-3
Alias:
Apopain; CASP-3; Caspase 3, apoptosis-related cysteine peptidase; Caspase-3; CPP32; CPP-32; CPP32B; Cysteine protease CPP32; ICE3; Protein Yama; SCA-1; SREBP cleavage activity 1; Yama; Yama protein
Type:
EC 3.4.22.56; EC 3.4.22.-; Protease; Apoptosis
Mass (Da):
31608
Number AA:
277
UniProt ID:
P42574
International Prot ID:
IPI00292140
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005739
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0043066
GO:0030264
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Caspase 3 (Q161-I172, cow) peptide with Tat sequence - Powder PE-01AMP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AMP95#TAT-CASP3(51-60) petide - Powder PE-01AMR95-P#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AMR95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
E
N
T
E
N
S
V
D
S
K
Site 2
S7
_
M
E
N
T
E
N
S
V
D
S
K
S
I
K
Site 3
S10
N
T
E
N
S
V
D
S
K
S
I
K
N
L
E
Site 4
S12
E
N
S
V
D
S
K
S
I
K
N
L
E
P
K
Site 5
S24
E
P
K
I
I
H
G
S
E
S
M
D
S
G
I
Site 6
S26
K
I
I
H
G
S
E
S
M
D
S
G
I
S
L
Site 7
S29
H
G
S
E
S
M
D
S
G
I
S
L
D
N
S
Site 8
S32
E
S
M
D
S
G
I
S
L
D
N
S
Y
K
M
Site 9
S36
S
G
I
S
L
D
N
S
Y
K
M
D
Y
P
E
Site 10
Y37
G
I
S
L
D
N
S
Y
K
M
D
Y
P
E
M
Site 11
Y41
D
N
S
Y
K
M
D
Y
P
E
M
G
L
C
I
Site 12
S58
N
N
K
N
F
H
K
S
T
G
M
T
S
R
S
Site 13
T62
F
H
K
S
T
G
M
T
S
R
S
G
T
D
V
Site 14
S65
S
T
G
M
T
S
R
S
G
T
D
V
D
A
A
Site 15
T67
G
M
T
S
R
S
G
T
D
V
D
A
A
N
L
Site 16
T77
D
A
A
N
L
R
E
T
F
R
N
L
K
Y
E
Site 17
Y83
E
T
F
R
N
L
K
Y
E
V
R
N
K
N
D
Site 18
T92
V
R
N
K
N
D
L
T
R
E
E
I
V
E
L
Site 19
S104
V
E
L
M
R
D
V
S
K
E
D
H
S
K
R
Site 20
S109
D
V
S
K
E
D
H
S
K
R
S
S
F
V
C
Site 21
S113
E
D
H
S
K
R
S
S
F
V
C
V
L
L
S
Site 22
S150
F
R
G
D
R
C
R
S
L
T
G
K
P
K
L
Site 23
T152
G
D
R
C
R
S
L
T
G
K
P
K
L
F
I
Site 24
S176
D
C
G
I
E
T
D
S
G
V
D
D
D
M
A
Site 25
Y197
E
A
D
F
L
Y
A
Y
S
T
A
P
G
Y
Y
Site 26
S198
A
D
F
L
Y
A
Y
S
T
A
P
G
Y
Y
S
Site 27
T199
D
F
L
Y
A
Y
S
T
A
P
G
Y
Y
S
W
Site 28
Y203
A
Y
S
T
A
P
G
Y
Y
S
W
R
N
S
K
Site 29
S205
S
T
A
P
G
Y
Y
S
W
R
N
S
K
D
G
Site 30
T245
R
V
N
R
K
V
A
T
E
F
E
S
F
S
F
Site 31
S249
K
V
A
T
E
F
E
S
F
S
F
D
A
T
F
Site 32
S251
A
T
E
F
E
S
F
S
F
D
A
T
F
H
A
Site 33
T255
E
S
F
S
F
D
A
T
F
H
A
K
K
Q
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation