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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTK
Full Name:
Megakaryocyte-associated tyrosine-protein kinase
Alias:
EC 2.7.1.112; EC 2.7.10.2; HYL; MATK
Type:
Protein-tyrosine kinase, TK group, Csk family
Mass (Da):
56469
Number AA:
507
UniProt ID:
P42679
International Prot ID:
IPI00000868
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007498
GO:0008284
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
G
R
G
S
L
V
S
W
R
A
F
H
G
C
Site 2
S18
R
A
F
H
G
C
D
S
A
E
E
L
P
R
V
Site 3
S26
A
E
E
L
P
R
V
S
P
R
F
L
R
A
W
Site 4
S39
A
W
H
P
P
P
V
S
A
R
M
P
T
R
R
Site 5
T44
P
V
S
A
R
M
P
T
R
R
W
A
P
G
T
Site 6
T51
T
R
R
W
A
P
G
T
Q
C
I
T
K
C
E
Site 7
T76
F
R
K
G
D
V
V
T
I
L
E
A
C
E
N
Site 8
S85
L
E
A
C
E
N
K
S
W
Y
R
V
K
H
H
Site 9
Y87
A
C
E
N
K
S
W
Y
R
V
K
H
H
T
S
Site 10
T93
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
Site 11
S112
L
R
E
R
E
A
L
S
A
D
P
K
L
S
L
Site 12
S118
L
S
A
D
P
K
L
S
L
M
P
W
F
H
G
Site 13
S149
G
L
F
L
V
R
E
S
A
R
H
P
G
D
Y
Site 14
Y169
F
G
R
D
V
I
H
Y
R
V
L
H
R
D
G
Site 15
Y196
L
M
D
M
V
E
H
Y
S
K
D
K
G
A
I
Site 16
S218
K
R
K
H
G
T
K
S
A
E
E
E
L
A
R
Site 17
T269
K
N
I
K
C
D
V
T
A
Q
A
F
L
D
E
Site 18
Y301
V
I
L
H
Q
G
L
Y
I
V
M
E
H
V
S
Site 19
T326
R
G
R
A
L
V
N
T
A
Q
L
L
Q
F
S
Site 20
Y342
H
V
A
E
G
M
E
Y
L
E
S
K
K
L
V
Site 21
S345
E
G
M
E
Y
L
E
S
K
K
L
V
H
R
D
Site 22
S383
A
E
R
K
G
L
D
S
S
R
L
P
V
K
W
Site 23
S384
E
R
K
G
L
D
S
S
R
L
P
V
K
W
T
Site 24
T402
A
L
K
H
G
K
F
T
S
K
S
D
V
W
S
Site 25
S403
L
K
H
G
K
F
T
S
K
S
D
V
W
S
F
Site 26
S405
H
G
K
F
T
S
K
S
D
V
W
S
F
G
V
Site 27
S409
T
S
K
S
D
V
W
S
F
G
V
L
L
W
E
Site 28
Y420
L
L
W
E
V
F
S
Y
G
R
A
P
Y
P
K
Site 29
Y425
F
S
Y
G
R
A
P
Y
P
K
M
S
L
K
E
Site 30
S429
R
A
P
Y
P
K
M
S
L
K
E
V
S
E
A
Site 31
S458
G
P
V
H
V
L
M
S
S
C
W
E
A
E
P
Site 32
S490
R
S
A
G
A
P
A
S
V
S
G
Q
D
A
D
Site 33
S492
A
G
A
P
A
S
V
S
G
Q
D
A
D
G
S
Site 34
S499
S
G
Q
D
A
D
G
S
T
S
P
R
S
Q
E
Site 35
T500
G
Q
D
A
D
G
S
T
S
P
R
S
Q
E
P
Site 36
S501
Q
D
A
D
G
S
T
S
P
R
S
Q
E
P
_
Site 37
S504
D
G
S
T
S
P
R
S
Q
E
P
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation