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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HELZ
Full Name:
Probable helicase with zinc finger domain
Alias:
DHRC; Down-regulated in cancers; DRHC; Helicase with zinc finger; HUMORF5; KIA0054; KIAA0054; Potential helicase with zinc-finger domain
Type:
DNA binding protein, helicase
Mass (Da):
218970
Number AA:
1942
UniProt ID:
P42694
International Prot ID:
IPI00000897
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004386
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
D
R
R
A
E
K
S
C
E
Q
A
C
E
S
Site 2
S16
S
C
E
Q
A
C
E
S
L
K
R
Q
D
Y
E
Site 3
Y22
E
S
L
K
R
Q
D
Y
E
M
A
L
K
H
C
Site 4
Y73
S
F
L
Q
L
K
N
Y
V
Q
A
D
E
D
C
Site 5
T113
G
K
L
Q
P
V
S
T
I
L
A
K
S
L
T
Site 6
T120
T
I
L
A
K
S
L
T
G
E
S
L
N
G
M
Site 7
T137
K
D
L
T
R
L
K
T
L
L
S
E
T
E
T
Site 8
S140
T
R
L
K
T
L
L
S
E
T
E
T
A
T
S
Site 9
T144
T
L
L
S
E
T
E
T
A
T
S
N
A
L
S
Site 10
S147
S
E
T
E
T
A
T
S
N
A
L
S
G
Y
H
Site 11
S151
T
A
T
S
N
A
L
S
G
Y
H
V
E
D
L
Site 12
Y153
T
S
N
A
L
S
G
Y
H
V
E
D
L
D
E
Site 13
T176
R
P
P
P
R
G
I
T
S
S
E
E
Y
T
L
Site 14
S178
P
P
R
G
I
T
S
S
E
E
Y
T
L
C
K
Site 15
Y181
G
I
T
S
S
E
E
Y
T
L
C
K
R
F
L
Site 16
T182
I
T
S
S
E
E
Y
T
L
C
K
R
F
L
E
Site 17
S217
E
W
Q
K
R
Y
A
S
R
L
I
K
L
K
Q
Site 18
S232
Q
N
E
N
K
Q
L
S
G
S
Y
M
E
T
L
Site 19
S234
E
N
K
Q
L
S
G
S
Y
M
E
T
L
I
E
Site 20
S246
L
I
E
K
W
M
N
S
L
S
P
E
K
V
L
Site 21
S248
E
K
W
M
N
S
L
S
P
E
K
V
L
S
E
Site 22
S254
L
S
P
E
K
V
L
S
E
C
I
E
G
V
K
Site 23
S269
V
E
H
N
P
D
L
S
V
T
V
S
T
K
K
Site 24
T271
H
N
P
D
L
S
V
T
V
S
T
K
K
S
H
Site 25
S273
P
D
L
S
V
T
V
S
T
K
K
S
H
Q
T
Site 26
T282
K
K
S
H
Q
T
W
T
F
A
L
T
C
K
P
Site 27
Y300
L
Y
R
V
A
L
L
Y
D
A
H
R
P
H
F
Site 28
S317
I
A
I
S
A
G
D
S
T
T
Q
V
S
Q
E
Site 29
T318
A
I
S
A
G
D
S
T
T
Q
V
S
Q
E
V
Site 30
S322
G
D
S
T
T
Q
V
S
Q
E
V
P
E
N
C
Site 31
Y345
A
Q
N
G
L
D
H
Y
V
Y
K
V
G
I
A
Site 32
Y347
N
G
L
D
H
Y
V
Y
K
V
G
I
A
F
N
Site 33
S385
R
V
M
I
D
A
A
S
T
E
D
L
E
Y
L
Site 34
Y391
A
S
T
E
D
L
E
Y
L
M
H
A
K
Q
Q
Site 35
S408
T
T
A
K
R
W
D
S
S
S
K
T
I
I
D
Site 36
S410
A
K
R
W
D
S
S
S
K
T
I
I
D
F
E
Site 37
T412
R
W
D
S
S
S
K
T
I
I
D
F
E
P
N
Site 38
T421
I
D
F
E
P
N
E
T
T
D
L
E
K
S
L
Site 39
S427
E
T
T
D
L
E
K
S
L
L
I
R
Y
Q
I
Site 40
Y432
E
K
S
L
L
I
R
Y
Q
I
P
L
S
A
D
Site 41
S437
I
R
Y
Q
I
P
L
S
A
D
Q
L
F
T
Q
Site 42
S445
A
D
Q
L
F
T
Q
S
V
L
D
K
S
L
T
Site 43
S450
T
Q
S
V
L
D
K
S
L
T
K
S
N
Y
Q
Site 44
T452
S
V
L
D
K
S
L
T
K
S
N
Y
Q
S
R
Site 45
S454
L
D
K
S
L
T
K
S
N
Y
Q
S
R
L
H
Site 46
Y456
K
S
L
T
K
S
N
Y
Q
S
R
L
H
D
L
Site 47
S458
L
T
K
S
N
Y
Q
S
R
L
H
D
L
L
Y
Site 48
Y465
S
R
L
H
D
L
L
Y
I
E
E
I
A
Q
Y
Site 49
Y472
Y
I
E
E
I
A
Q
Y
K
E
I
S
K
F
N
Site 50
Y501
G
V
S
G
G
A
K
Y
A
Q
N
G
Q
L
F
Site 51
T514
L
F
G
R
F
K
L
T
E
T
L
S
E
D
T
Site 52
T516
G
R
F
K
L
T
E
T
L
S
E
D
T
L
A
Site 53
S518
F
K
L
T
E
T
L
S
E
D
T
L
A
G
R
Site 54
T521
T
E
T
L
S
E
D
T
L
A
G
R
L
V
M
Site 55
Y555
Q
G
T
K
E
K
V
Y
E
A
T
I
E
E
K
Site 56
S572
E
Y
I
F
L
R
L
S
R
E
C
C
E
E
L
Site 57
T587
N
L
R
P
D
C
D
T
Q
V
E
L
Q
F
Q
Site 58
Y605
L
P
L
C
E
M
H
Y
A
L
D
R
I
K
D
Site 59
T625
P
D
I
S
M
T
P
T
I
P
W
S
P
N
R
Site 60
T697
E
T
R
I
L
I
C
T
H
S
N
S
A
A
D
Site 61
Y706
S
N
S
A
A
D
L
Y
I
K
D
Y
L
H
P
Site 62
Y710
A
D
L
Y
I
K
D
Y
L
H
P
Y
V
E
A
Site 63
Y714
I
K
D
Y
L
H
P
Y
V
E
A
G
N
P
Q
Site 64
Y728
Q
A
R
P
L
R
V
Y
F
R
N
R
W
V
K
Site 65
S752
C
L
I
S
S
A
H
S
T
F
Q
M
P
Q
K
Site 66
T753
L
I
S
S
A
H
S
T
F
Q
M
P
Q
K
E
Site 67
T774
V
V
V
V
T
L
N
T
S
Q
Y
L
C
Q
L
Site 68
Y777
V
T
L
N
T
S
Q
Y
L
C
Q
L
D
L
E
Site 69
S827
A
G
D
H
M
Q
L
S
P
F
V
Y
S
E
F
Site 70
Y831
M
Q
L
S
P
F
V
Y
S
E
F
A
R
E
R
Site 71
S843
R
E
R
N
L
H
V
S
L
L
D
R
L
Y
E
Site 72
Y849
V
S
L
L
D
R
L
Y
E
H
Y
P
A
E
F
Site 73
Y852
L
D
R
L
Y
E
H
Y
P
A
E
F
P
C
R
Site 74
Y866
R
I
L
L
C
E
N
Y
R
S
H
E
A
I
I
Site 75
Y875
S
H
E
A
I
I
N
Y
T
S
E
L
F
Y
E
Site 76
Y881
N
Y
T
S
E
L
F
Y
E
G
K
L
M
A
S
Site 77
Y898
Q
P
A
H
K
D
F
Y
P
L
T
F
F
T
A
Site 78
T901
H
K
D
F
Y
P
L
T
F
F
T
A
R
G
E
Site 79
Y919
E
K
N
S
T
A
F
Y
N
N
A
E
V
F
E
Site 80
S949
W
G
K
L
D
D
G
S
I
G
V
V
T
P
Y
Site 81
S973
E
L
R
K
K
R
L
S
D
V
N
V
E
R
V
Site 82
S994
Q
F
R
V
L
F
L
S
T
V
R
T
R
H
T
Site 83
T998
L
F
L
S
T
V
R
T
R
H
T
C
K
H
K
Site 84
T1001
S
T
V
R
T
R
H
T
C
K
H
K
Q
T
P
Site 85
T1007
H
T
C
K
H
K
Q
T
P
I
K
K
K
E
Q
Site 86
S1019
K
E
Q
L
L
E
D
S
T
E
D
L
D
Y
G
Site 87
T1020
E
Q
L
L
E
D
S
T
E
D
L
D
Y
G
F
Site 88
Y1025
D
S
T
E
D
L
D
Y
G
F
L
S
N
Y
K
Site 89
S1029
D
L
D
Y
G
F
L
S
N
Y
K
L
L
N
T
Site 90
S1076
A
L
C
H
E
N
S
S
L
H
G
I
T
F
E
Site 91
T1081
N
S
S
L
H
G
I
T
F
E
Q
I
K
A
Q
Site 92
S1117
R
A
L
R
L
Q
H
S
G
S
T
N
K
Q
Q
Site 93
S1119
L
R
L
Q
H
S
G
S
T
N
K
Q
Q
Q
S
Site 94
S1126
S
T
N
K
Q
Q
Q
S
P
P
K
G
K
S
L
Site 95
S1132
Q
S
P
P
K
G
K
S
L
H
H
T
Q
N
D
Site 96
T1136
K
G
K
S
L
H
H
T
Q
N
D
H
F
Q
N
Site 97
Y1162
I
G
N
P
I
R
A
Y
T
P
P
P
P
L
G
Site 98
T1163
G
N
P
I
R
A
Y
T
P
P
P
P
L
G
P
Site 99
S1177
P
H
P
N
L
G
K
S
P
S
P
V
Q
R
I
Site 100
S1179
P
N
L
G
K
S
P
S
P
V
Q
R
I
D
P
Site 101
T1188
V
Q
R
I
D
P
H
T
G
T
S
I
L
Y
V
Site 102
T1214
V
P
L
P
V
P
W
T
G
Y
Q
G
R
F
A
Site 103
Y1216
L
P
V
P
W
T
G
Y
Q
G
R
F
A
V
D
Site 104
S1247
L
Q
T
H
G
R
G
S
P
I
P
Y
G
L
G
Site 105
Y1251
G
R
G
S
P
I
P
Y
G
L
G
H
H
P
P
Site 106
T1260
L
G
H
H
P
P
V
T
I
G
Q
P
Q
N
Q
Site 107
S1282
E
Q
N
R
N
G
K
S
D
T
N
N
S
G
P
Site 108
T1284
N
R
N
G
K
S
D
T
N
N
S
G
P
E
I
Site 109
S1287
G
K
S
D
T
N
N
S
G
P
E
I
N
K
I
Site 110
T1296
P
E
I
N
K
I
R
T
P
E
K
K
P
T
E
Site 111
T1302
R
T
P
E
K
K
P
T
E
P
K
Q
V
D
L
Site 112
S1311
P
K
Q
V
D
L
E
S
N
P
Q
N
R
S
P
Site 113
S1317
E
S
N
P
Q
N
R
S
P
E
S
R
P
S
V
Site 114
S1320
P
Q
N
R
S
P
E
S
R
P
S
V
V
Y
P
Site 115
S1323
R
S
P
E
S
R
P
S
V
V
Y
P
S
T
K
Site 116
Y1326
E
S
R
P
S
V
V
Y
P
S
T
K
F
P
R
Site 117
S1328
R
P
S
V
V
Y
P
S
T
K
F
P
R
K
D
Site 118
T1329
P
S
V
V
Y
P
S
T
K
F
P
R
K
D
N
Site 119
Y1353
L
P
A
P
H
A
Q
Y
A
I
P
N
R
H
F
Site 120
S1420
Q
Q
P
P
P
Q
L
S
P
A
Y
Q
A
G
P
Site 121
Y1423
P
P
Q
L
S
P
A
Y
Q
A
G
P
N
N
A
Site 122
S1442
A
V
A
H
R
P
Q
S
P
P
A
E
A
V
I
Site 123
S1463
P
M
L
Q
E
G
H
S
P
L
R
A
I
A
Q
Site 124
S1477
Q
P
G
P
I
L
P
S
H
L
N
S
F
I
D
Site 125
S1481
I
L
P
S
H
L
N
S
F
I
D
E
N
P
S
Site 126
S1488
S
F
I
D
E
N
P
S
G
L
P
I
G
E
A
Site 127
T1507
H
G
S
V
A
L
E
T
L
R
Q
Q
Q
A
R
Site 128
S1526
S
E
H
H
A
F
L
S
Q
G
S
A
P
Y
P
Site 129
Y1532
L
S
Q
G
S
A
P
Y
P
H
H
H
H
P
H
Site 130
S1564
A
D
W
K
L
T
S
S
A
E
D
E
V
E
T
Site 131
T1572
A
E
D
E
V
E
T
T
Y
S
R
F
Q
D
L
Site 132
Y1573
E
D
E
V
E
T
T
Y
S
R
F
Q
D
L
I
Site 133
S1574
D
E
V
E
T
T
Y
S
R
F
Q
D
L
I
R
Site 134
S1584
Q
D
L
I
R
E
L
S
H
R
D
Q
S
E
T
Site 135
S1589
E
L
S
H
R
D
Q
S
E
T
R
E
L
A
E
Site 136
T1591
S
H
R
D
Q
S
E
T
R
E
L
A
E
M
P
Site 137
S1602
A
E
M
P
P
P
Q
S
R
L
L
Q
Y
R
Q
Site 138
Y1607
P
Q
S
R
L
L
Q
Y
R
Q
V
Q
S
R
S
Site 139
S1614
Y
R
Q
V
Q
S
R
S
P
P
A
V
P
S
P
Site 140
S1620
R
S
P
P
A
V
P
S
P
P
S
S
T
D
H
Site 141
S1623
P
A
V
P
S
P
P
S
S
T
D
H
S
S
H
Site 142
S1624
A
V
P
S
P
P
S
S
T
D
H
S
S
H
F
Site 143
T1625
V
P
S
P
P
S
S
T
D
H
S
S
H
F
S
Site 144
S1628
P
P
S
S
T
D
H
S
S
H
F
S
N
F
N
Site 145
S1629
P
S
S
T
D
H
S
S
H
F
S
N
F
N
D
Site 146
S1632
T
D
H
S
S
H
F
S
N
F
N
D
N
S
R
Site 147
S1645
S
R
D
I
E
V
A
S
N
P
A
F
P
Q
R
Site 148
S1660
L
P
P
Q
I
F
N
S
P
F
S
L
P
S
E
Site 149
S1663
Q
I
F
N
S
P
F
S
L
P
S
E
H
L
A
Site 150
S1666
N
S
P
F
S
L
P
S
E
H
L
A
P
P
P
Site 151
Y1676
L
A
P
P
P
L
K
Y
L
A
P
D
G
A
W
Site 152
T1684
L
A
P
D
G
A
W
T
F
A
N
L
Q
Q
N
Site 153
S1733
Q
E
P
F
H
P
L
S
S
R
T
V
S
S
S
Site 154
S1734
E
P
F
H
P
L
S
S
R
T
V
S
S
S
S
Site 155
T1736
F
H
P
L
S
S
R
T
V
S
S
S
S
L
P
Site 156
S1738
P
L
S
S
R
T
V
S
S
S
S
L
P
S
L
Site 157
S1739
L
S
S
R
T
V
S
S
S
S
L
P
S
L
E
Site 158
S1740
S
S
R
T
V
S
S
S
S
L
P
S
L
E
E
Site 159
S1741
S
R
T
V
S
S
S
S
L
P
S
L
E
E
Y
Site 160
S1744
V
S
S
S
S
L
P
S
L
E
E
Y
E
P
R
Site 161
Y1748
S
L
P
S
L
E
E
Y
E
P
R
G
P
G
R
Site 162
Y1758
R
G
P
G
R
P
L
Y
Q
R
R
I
S
S
S
Site 163
S1763
P
L
Y
Q
R
R
I
S
S
S
S
V
Q
P
C
Site 164
S1764
L
Y
Q
R
R
I
S
S
S
S
V
Q
P
C
S
Site 165
S1765
Y
Q
R
R
I
S
S
S
S
V
Q
P
C
S
E
Site 166
S1766
Q
R
R
I
S
S
S
S
V
Q
P
C
S
E
E
Site 167
S1771
S
S
S
V
Q
P
C
S
E
E
V
S
T
P
Q
Site 168
S1775
Q
P
C
S
E
E
V
S
T
P
Q
D
S
L
A
Site 169
T1776
P
C
S
E
E
V
S
T
P
Q
D
S
L
A
Q
Site 170
S1780
E
V
S
T
P
Q
D
S
L
A
Q
C
K
E
L
Site 171
S1794
L
Q
D
H
S
N
Q
S
S
F
N
F
S
S
P
Site 172
S1795
Q
D
H
S
N
Q
S
S
F
N
F
S
S
P
E
Site 173
S1799
N
Q
S
S
F
N
F
S
S
P
E
S
W
V
N
Site 174
S1800
Q
S
S
F
N
F
S
S
P
E
S
W
V
N
T
Site 175
S1803
F
N
F
S
S
P
E
S
W
V
N
T
T
S
S
Site 176
T1807
S
P
E
S
W
V
N
T
T
S
S
T
P
Y
Q
Site 177
S1809
E
S
W
V
N
T
T
S
S
T
P
Y
Q
N
I
Site 178
S1810
S
W
V
N
T
T
S
S
T
P
Y
Q
N
I
P
Site 179
T1811
W
V
N
T
T
S
S
T
P
Y
Q
N
I
P
C
Site 180
Y1813
N
T
T
S
S
T
P
Y
Q
N
I
P
C
N
G
Site 181
S1821
Q
N
I
P
C
N
G
S
S
R
T
A
Q
P
R
Site 182
T1836
E
L
I
A
P
P
K
T
V
K
P
P
E
D
Q
Site 183
S1846
P
P
E
D
Q
L
K
S
E
N
L
E
V
S
S
Site 184
S1852
K
S
E
N
L
E
V
S
S
S
F
N
Y
S
V
Site 185
S1854
E
N
L
E
V
S
S
S
F
N
Y
S
V
L
Q
Site 186
Y1857
E
V
S
S
S
F
N
Y
S
V
L
Q
H
L
G
Site 187
S1858
V
S
S
S
F
N
Y
S
V
L
Q
H
L
G
Q
Site 188
S1878
P
N
K
Q
I
A
E
S
A
N
S
S
S
P
Q
Site 189
S1881
Q
I
A
E
S
A
N
S
S
S
P
Q
S
S
A
Site 190
S1882
I
A
E
S
A
N
S
S
S
P
Q
S
S
A
G
Site 191
S1883
A
E
S
A
N
S
S
S
P
Q
S
S
A
G
G
Site 192
S1886
A
N
S
S
S
P
Q
S
S
A
G
G
K
P
A
Site 193
S1887
N
S
S
S
P
Q
S
S
A
G
G
K
P
A
M
Site 194
S1895
A
G
G
K
P
A
M
S
Y
A
S
A
L
R
A
Site 195
Y1896
G
G
K
P
A
M
S
Y
A
S
A
L
R
A
P
Site 196
S1916
P
P
E
Q
A
K
K
S
S
D
P
L
S
L
F
Site 197
S1917
P
E
Q
A
K
K
S
S
D
P
L
S
L
F
Q
Site 198
S1921
K
K
S
S
D
P
L
S
L
F
Q
E
L
S
L
Site 199
S1930
F
Q
E
L
S
L
G
S
S
S
G
S
N
G
F
Site 200
S1931
Q
E
L
S
L
G
S
S
S
G
S
N
G
F
Y
Site 201
S1932
E
L
S
L
G
S
S
S
G
S
N
G
F
Y
S
Site 202
S1934
S
L
G
S
S
S
G
S
N
G
F
Y
S
Y
F
Site 203
Y1938
S
S
G
S
N
G
F
Y
S
Y
F
K
_
_
_
Site 204
Y1940
G
S
N
G
F
Y
S
Y
F
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation