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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACAA2
Full Name:
3-ketoacyl-CoA thiolase, mitochondrial
Alias:
Acetyl-CoA acyltransferase; Beta-ketothiolase; DSAEC; EC 2.3.1.16; THIM
Type:
Enzyme - Acetyltransferase
Mass (Da):
41924
Number AA:
397
UniProt ID:
P42765
International Prot ID:
IPI00001539
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003988
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
GO:0006631
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
K
R
T
P
F
G
A
Y
G
G
L
L
K
D
F
Site 2
T28
G
G
L
L
K
D
F
T
A
T
D
L
S
E
F
Site 3
S64
G
N
V
L
Q
S
S
S
D
A
I
Y
L
A
R
Site 4
Y68
Q
S
S
S
D
A
I
Y
L
A
R
H
V
G
L
Site 5
T83
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
Site 6
T87
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
Site 7
T119
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Site 8
S121
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
C
Site 9
S123
C
G
G
T
E
S
M
S
Q
A
P
Y
C
V
R
Site 10
Y127
E
S
M
S
Q
A
P
Y
C
V
R
N
V
R
F
Site 11
T136
V
R
N
V
R
F
G
T
K
L
G
S
D
I
K
Site 12
S140
R
F
G
T
K
L
G
S
D
I
K
L
E
D
S
Site 13
S147
S
D
I
K
L
E
D
S
L
W
V
S
L
T
D
Site 14
S151
L
E
D
S
L
W
V
S
L
T
D
Q
H
V
Q
Site 15
T153
D
S
L
W
V
S
L
T
D
Q
H
V
Q
L
P
Site 16
Y182
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
Site 17
Y198
K
A
A
N
D
A
G
Y
F
N
D
E
M
A
P
Site 18
T216
K
T
K
K
G
K
Q
T
M
Q
V
D
E
H
A
Site 19
T227
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
Site 20
T244
P
V
F
K
K
D
G
T
V
T
A
G
N
A
S
Site 21
Y327
N
E
A
F
A
P
Q
Y
L
A
V
E
R
S
L
Site 22
S333
Q
Y
L
A
V
E
R
S
L
D
L
D
I
S
K
Site 23
S339
R
S
L
D
L
D
I
S
K
T
N
V
N
G
G
Site 24
S357
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
Site 25
S359
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
Site 26
T362
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
Site 27
Y376
L
R
R
R
G
G
K
Y
A
V
G
S
A
C
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation