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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRCP
Full Name:
Lysosomal Pro-X carboxypeptidase
Alias:
Angiotensinase C;Lysosomal carboxypeptidase C;Proline carboxypeptidase;Prolylcarboxypeptidase
Type:
Mass (Da):
55800
Number AA:
496
UniProt ID:
P42785
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
P
A
L
R
A
L
G
S
L
H
L
P
T
N
P
Site 2
T36
L
G
S
L
H
L
P
T
N
P
T
S
L
P
A
Site 3
S40
H
L
P
T
N
P
T
S
L
P
A
V
A
K
N
Site 4
S49
P
A
V
A
K
N
Y
S
V
L
Y
F
Q
Q
K
Site 5
Y52
A
K
N
Y
S
V
L
Y
F
Q
Q
K
V
D
H
Site 6
T64
V
D
H
F
G
F
N
T
V
K
T
F
N
Q
R
Site 7
T67
F
G
F
N
T
V
K
T
F
N
Q
R
Y
L
V
Site 8
Y72
V
K
T
F
N
Q
R
Y
L
V
A
D
K
Y
W
Site 9
Y78
R
Y
L
V
A
D
K
Y
W
K
K
N
G
G
S
Site 10
Y89
N
G
G
S
I
L
F
Y
T
G
N
E
G
D
I
Site 11
Y124
L
V
F
A
E
H
R
Y
Y
G
E
S
L
P
F
Site 12
Y125
V
F
A
E
H
R
Y
Y
G
E
S
L
P
F
G
Site 13
S128
E
H
R
Y
Y
G
E
S
L
P
F
G
D
N
S
Site 14
S135
S
L
P
F
G
D
N
S
F
K
D
S
R
H
L
Site 15
S139
G
D
N
S
F
K
D
S
R
H
L
N
F
L
T
Site 16
T146
S
R
H
L
N
F
L
T
S
E
Q
A
L
A
D
Site 17
S147
R
H
L
N
F
L
T
S
E
Q
A
L
A
D
F
Site 18
T224
V
F
M
K
I
V
T
T
D
F
R
K
S
G
P
Site 19
S229
V
T
T
D
F
R
K
S
G
P
H
C
S
E
S
Site 20
S234
R
K
S
G
P
H
C
S
E
S
I
H
R
S
W
Site 21
S236
S
G
P
H
C
S
E
S
I
H
R
S
W
D
A
Site 22
S240
C
S
E
S
I
H
R
S
W
D
A
I
N
R
L
Site 23
S248
W
D
A
I
N
R
L
S
N
T
G
S
G
L
Q
Site 24
S252
N
R
L
S
N
T
G
S
G
L
Q
W
L
T
G
Site 25
T268
L
H
L
C
S
P
L
T
S
Q
D
I
Q
H
L
Site 26
S269
H
L
C
S
P
L
T
S
Q
D
I
Q
H
L
K
Site 27
Y312
P
I
K
V
V
C
Q
Y
L
K
N
P
N
V
S
Site 28
S321
K
N
P
N
V
S
D
S
L
L
L
Q
N
I
F
Site 29
Y335
F
Q
A
L
N
V
Y
Y
N
Y
S
G
Q
V
K
Site 30
S347
Q
V
K
C
L
N
I
S
E
T
A
T
S
S
L
Site 31
T349
K
C
L
N
I
S
E
T
A
T
S
S
L
G
T
Site 32
S352
N
I
S
E
T
A
T
S
S
L
G
T
L
G
W
Site 33
S353
I
S
E
T
A
T
S
S
L
G
T
L
G
W
S
Site 34
T356
T
A
T
S
S
L
G
T
L
G
W
S
Y
Q
A
Site 35
S384
D
D
M
F
E
P
H
S
W
N
L
K
E
L
S
Site 36
T408
R
P
R
P
S
W
I
T
T
M
Y
G
G
K
N
Site 37
T409
P
R
P
S
W
I
T
T
M
Y
G
G
K
N
I
Site 38
Y411
P
S
W
I
T
T
M
Y
G
G
K
N
I
S
S
Site 39
T420
G
K
N
I
S
S
H
T
N
I
V
F
S
N
G
Site 40
S433
N
G
E
L
D
P
W
S
G
G
G
V
T
K
D
Site 41
S469
K
N
A
L
D
P
M
S
V
L
L
A
R
S
L
Site 42
Y489
K
N
W
I
R
D
F
Y
D
S
A
G
K
Q
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation