PhosphoNET

           
Protein Info 
   
Short Name:  HTT
Full Name:  Huntingtin
Alias:  HD; HD protein; HDH; Huntington's disease protein; Huntington's disease protein homolog; IT15; NT17
Type:  Cytoskeletal protein
Mass (Da):  347860
Number AA:  3144
UniProt ID:  P42858
International Prot ID:  IPI00002335
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005794  GO:0005634  GO:0005625 Uniprot OncoNet
Molecular Function:  GO:0008017  GO:0003714  GO:0005215 PhosphoSite+ KinaseNET
Biological Process:  GO:0006917    GO:0009887 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T3_____MATLEKLMKA
Site 2S13KLMKAFESLKSFQQQ
Site 3S16KAFESLKSFQQQQQQ
Site 4S263AFIANLKSSSPTIRR
Site 5Y288QHSRRTQYFYSWLLN
Site 6S350TRKEMEVSPSAEQLV
Site 7S417KEESGGRSRSGSIVE
Site 8S419ESGGRSRSGSIVELI
Site 9S432LIAGGGSSCSPVLSR
Site 10S457EEALEDDSESRSDVS
Site 11S459ALEDDSESRSDVSSS
Site 12S464SESRSDVSSSALTAS
Site 13S533GDEEDILSHSSSQVS
Site 14S535EEDILSHSSSQVSAV
Site 15S561TQASSPISDSSQTTT
Site 16S578PDSAVTPSDSSEIVL
Site 17S642MSHCRQPSDSSVDKF
Site 18T798DWMGTIRTLTGNTFS
Site 19S978TQPPSHFSVSTITRI
Site 20S1055HCGVPPLSASDESRK
Site 21S1179PSLTNPPSLSPIRRK
Site 22S1224TSGPVTTSKSSSLGS
Site 23S1226GPVTTSKSSSLGSFY
Site 24S1338DGLSSNPSKSQGRAQ
Site 25S1349GRAQRLGSSSVRPGL
Site 26Y1357SSVRPGLYHYCFMAP
Site 27S1721NRLRDGDSTSTLEEH
Site 28T1722RLRDGDSTSTLEEHS
Site 29S1864QQTPKRHSLSSTKLL
Site 30S1931NHIQDLISLSHEPPV
Site 31T1968SRCENLSTPTMLKKT
Site 32S2072RLSTMQDSLSPSPPV
Site 33S2074STMQDSLSPSPPVSS
Site 34S2114KSQCWTRSDSALLEG
Site 35T2335LLSPERRTNTPKAIS
Site 36S2584QAWDPVPSLSPATTG
Site 37S2611NPERELGSMSYKLGQ
Site 38S2688YSRWILPSSSARRTP
Site 39S2866QMCGVMLSGSEESTP
Site 40S3041VRDWVMLSLSNFTQR
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation