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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAFAH1B1
Full Name:
Platelet-activating factor acetylhydrolase IB subunit alpha
Alias:
LIS1; LIS-1; Lissencephaly-1 protein; MDCR; MDS; PAF acetylhydrolase 45 kDa subunit; PAFAH; PAF-AH 45 kDa subunit; PAFAH alpha; PAF-AH alpha; Platelet-activating factor acetylhydrolase IB alpha subunit; Platelet-activating factor acetylhydrolase, isoform Ib, subunit 1
Type:
Lipid Metabolism - ether lipid; Cell cycle regulation
Mass (Da):
46638
Number AA:
409
UniProt ID:
P43034
International Prot ID:
IPI00218728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000235
GO:0005938
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0034452
GO:0008201
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0001675
GO:0030036
GO:0008344
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
L
N
R
A
I
A
D
Y
L
R
S
N
G
Y
E
Site 2
Y24
D
Y
L
R
S
N
G
Y
E
E
A
Y
S
V
F
Site 3
Y28
S
N
G
Y
E
E
A
Y
S
V
F
K
K
E
A
Site 4
S29
N
G
Y
E
E
A
Y
S
V
F
K
K
E
A
E
Site 5
Y47
N
E
E
L
D
K
K
Y
A
G
L
L
E
K
K
Site 6
T56
G
L
L
E
K
K
W
T
S
V
I
R
L
Q
K
Site 7
S57
L
L
E
K
K
W
T
S
V
I
R
L
Q
K
K
Site 8
S81
E
A
K
E
E
F
T
S
G
G
P
L
G
Q
K
Site 9
Y102
I
P
R
P
P
E
K
Y
A
L
S
G
H
R
S
Site 10
S105
P
P
E
K
Y
A
L
S
G
H
R
S
P
V
T
Site 11
S109
Y
A
L
S
G
H
R
S
P
V
T
R
V
I
F
Site 12
T112
S
G
H
R
S
P
V
T
R
V
I
F
H
P
V
Site 13
T131
V
S
A
S
E
D
A
T
I
K
V
W
D
Y
E
Site 14
Y137
A
T
I
K
V
W
D
Y
E
T
G
D
F
E
R
Site 15
S152
T
L
K
G
H
T
D
S
V
Q
D
I
S
F
D
Site 16
S157
T
D
S
V
Q
D
I
S
F
D
H
S
G
K
L
Site 17
S161
Q
D
I
S
F
D
H
S
G
K
L
L
A
S
C
Site 18
S197
G
H
D
H
N
V
S
S
V
A
I
M
P
N
G
Site 19
T215
V
S
A
S
R
D
K
T
I
K
M
W
E
V
Q
Site 20
T247
V
R
P
N
Q
D
G
T
L
I
A
S
C
S
N
Site 21
S251
Q
D
G
T
L
I
A
S
C
S
N
D
Q
T
V
Site 22
S283
E
H
V
V
E
C
I
S
W
A
P
E
S
S
Y
Site 23
S288
C
I
S
W
A
P
E
S
S
Y
S
S
I
S
E
Site 24
S289
I
S
W
A
P
E
S
S
Y
S
S
I
S
E
A
Site 25
Y290
S
W
A
P
E
S
S
Y
S
S
I
S
E
A
T
Site 26
S291
W
A
P
E
S
S
Y
S
S
I
S
E
A
T
G
Site 27
S292
A
P
E
S
S
Y
S
S
I
S
E
A
T
G
S
Site 28
S294
E
S
S
Y
S
S
I
S
E
A
T
G
S
E
T
Site 29
S299
S
I
S
E
A
T
G
S
E
T
K
K
S
G
K
Site 30
S304
T
G
S
E
T
K
K
S
G
K
P
G
P
F
L
Site 31
S313
K
P
G
P
F
L
L
S
G
S
R
D
K
T
I
Site 32
S315
G
P
F
L
L
S
G
S
R
D
K
T
I
K
M
Site 33
T319
L
S
G
S
R
D
K
T
I
K
M
W
D
V
S
Site 34
S355
S
G
G
K
F
I
L
S
C
A
D
D
K
T
L
Site 35
T361
L
S
C
A
D
D
K
T
L
R
V
W
D
Y
K
Site 36
Y367
K
T
L
R
V
W
D
Y
K
N
K
R
C
M
K
Site 37
T384
N
A
H
E
H
F
V
T
S
L
D
F
H
K
T
Site 38
T391
T
S
L
D
F
H
K
T
A
P
Y
V
V
T
G
Site 39
Y394
D
F
H
K
T
A
P
Y
V
V
T
G
S
V
D
Site 40
T403
V
T
G
S
V
D
Q
T
V
K
V
W
E
C
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation