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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTSO
Full Name:
Cathepsin O
Alias:
cathepsin O; CATO; CTSO1
Type:
EC 3.4.22.42; Cytoskeletal protein; Protease
Mass (Da):
35960
Number AA:
UniProt ID:
P43234
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004197
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
R
G
G
G
D
A
D
S
R
A
P
F
T
P
T
Site 2
T30
A
D
S
R
A
P
F
T
P
T
W
P
R
S
R
Site 3
T32
S
R
A
P
F
T
P
T
W
P
R
S
R
E
R
Site 4
S36
F
T
P
T
W
P
R
S
R
E
R
E
A
A
A
Site 5
S47
E
A
A
A
F
R
E
S
L
N
R
H
R
Y
L
Site 6
Y53
E
S
L
N
R
H
R
Y
L
N
S
L
F
P
S
Site 7
S56
N
R
H
R
Y
L
N
S
L
F
P
S
E
N
S
Site 8
S60
Y
L
N
S
L
F
P
S
E
N
S
T
A
F
Y
Site 9
S63
S
L
F
P
S
E
N
S
T
A
F
Y
G
I
N
Site 10
T64
L
F
P
S
E
N
S
T
A
F
Y
G
I
N
Q
Site 11
Y67
S
E
N
S
T
A
F
Y
G
I
N
Q
F
S
Y
Site 12
Y74
Y
G
I
N
Q
F
S
Y
L
F
P
E
E
F
K
Site 13
Y84
P
E
E
F
K
A
I
Y
L
R
S
K
P
S
K
Site 14
S87
F
K
A
I
Y
L
R
S
K
P
S
K
F
P
R
Site 15
S90
I
Y
L
R
S
K
P
S
K
F
P
R
Y
S
A
Site 16
S96
P
S
K
F
P
R
Y
S
A
E
V
H
M
S
I
Site 17
Y145
V
G
A
V
E
S
A
Y
A
I
K
G
K
P
L
Site 18
S156
G
K
P
L
E
D
L
S
V
Q
Q
V
I
D
C
Site 19
Y168
I
D
C
S
Y
N
N
Y
G
C
N
G
G
S
T
Site 20
S193
Q
V
K
L
V
K
D
S
E
Y
P
F
K
A
Q
Site 21
Y195
K
L
V
K
D
S
E
Y
P
F
K
A
Q
N
G
Site 22
Y206
A
Q
N
G
L
C
H
Y
F
S
G
S
H
S
G
Site 23
S208
N
G
L
C
H
Y
F
S
G
S
H
S
G
F
S
Site 24
S210
L
C
H
Y
F
S
G
S
H
S
G
F
S
I
K
Site 25
S212
H
Y
F
S
G
S
H
S
G
F
S
I
K
G
Y
Site 26
S215
S
G
S
H
S
G
F
S
I
K
G
Y
S
A
Y
Site 27
Y219
S
G
F
S
I
K
G
Y
S
A
Y
D
F
S
D
Site 28
S220
G
F
S
I
K
G
Y
S
A
Y
D
F
S
D
Q
Site 29
Y222
S
I
K
G
Y
S
A
Y
D
F
S
D
Q
E
D
Site 30
S225
G
Y
S
A
Y
D
F
S
D
Q
E
D
E
M
A
Site 31
Y253
D
A
V
S
W
Q
D
Y
L
G
G
I
I
Q
H
Site 32
T279
L
I
T
G
F
D
K
T
G
S
T
P
Y
W
I
Site 33
S281
T
G
F
D
K
T
G
S
T
P
Y
W
I
V
R
Site 34
T282
G
F
D
K
T
G
S
T
P
Y
W
I
V
R
N
Site 35
Y284
D
K
T
G
S
T
P
Y
W
I
V
R
N
S
W
Site 36
S294
V
R
N
S
W
G
S
S
W
G
V
D
G
Y
A
Site 37
Y300
S
S
W
G
V
D
G
Y
A
H
V
K
M
G
S
Site 38
S315
N
V
C
G
I
A
D
S
V
S
S
I
F
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation