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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
cathepsin K
Full Name:
Cathepsin K
Alias:
Cathepsin K precursor; Cathepsin O; Cathepsin O2; Cathepsin X; CATK; CTSK; CTSO; CTSO2; EC 3.4.22.38; PKND; PYCD
Type:
Protease; EC 3.4.22.38
Mass (Da):
36966
Number AA:
329
UniProt ID:
P43235
International Prot ID:
IPI00300599
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
K
K
T
H
R
K
Q
Y
N
N
K
V
D
E
I
Site 2
S45
N
N
K
V
D
E
I
S
R
R
L
I
W
E
K
Site 3
Y56
I
W
E
K
N
L
K
Y
I
S
I
H
N
L
E
Site 4
S58
E
K
N
L
K
Y
I
S
I
H
N
L
E
A
S
Site 5
S65
S
I
H
N
L
E
A
S
L
G
V
H
T
Y
E
Site 6
S83
N
H
L
G
D
M
T
S
E
E
V
V
Q
K
M
Site 7
S98
T
G
L
K
V
P
L
S
H
S
R
S
N
D
T
Site 8
S100
L
K
V
P
L
S
H
S
R
S
N
D
T
L
Y
Site 9
S102
V
P
L
S
H
S
R
S
N
D
T
L
Y
I
P
Site 10
T105
S
H
S
R
S
N
D
T
L
Y
I
P
E
W
E
Site 11
Y107
S
R
S
N
D
T
L
Y
I
P
E
W
E
G
R
Site 12
S118
W
E
G
R
A
P
D
S
V
D
Y
R
K
K
G
Site 13
Y121
R
A
P
D
S
V
D
Y
R
K
K
G
Y
V
T
Site 14
Y126
V
D
Y
R
K
K
G
Y
V
T
P
V
K
N
Q
Site 15
T128
Y
R
K
K
G
Y
V
T
P
V
K
N
Q
G
Q
Site 16
S163
T
G
K
L
L
N
L
S
P
Q
N
L
V
D
C
Site 17
S172
Q
N
L
V
D
C
V
S
E
N
D
G
C
G
G
Site 18
Y188
Y
M
T
N
A
F
Q
Y
V
Q
K
N
R
G
I
Site 19
S197
Q
K
N
R
G
I
D
S
E
D
A
Y
P
Y
V
Site 20
Y201
G
I
D
S
E
D
A
Y
P
Y
V
G
Q
E
E
Site 21
Y203
D
S
E
D
A
Y
P
Y
V
G
Q
E
E
S
C
Site 22
Y212
G
Q
E
E
S
C
M
Y
N
P
T
G
K
A
A
Site 23
Y224
K
A
A
K
C
R
G
Y
R
E
I
P
E
G
N
Site 24
S246
V
A
R
V
G
P
V
S
V
A
I
D
A
S
L
Site 25
S255
A
I
D
A
S
L
T
S
F
Q
F
Y
S
K
G
Site 26
Y259
S
L
T
S
F
Q
F
Y
S
K
G
V
Y
Y
D
Site 27
S260
L
T
S
F
Q
F
Y
S
K
G
V
Y
Y
D
E
Site 28
Y264
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
N
S
Site 29
Y265
F
Y
S
K
G
V
Y
Y
D
E
S
C
N
S
D
Site 30
Y307
E
N
W
G
N
K
G
Y
I
L
M
A
R
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation