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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MSH2
Full Name:
DNA mismatch repair protein Msh2
Alias:
COCA1; FCC1; HNPCC; HNPCC1; MutS (E. coli) homolog 2; MutS 2, colon cancer, nonpolyposis type 1; MutS homolog 2 (E. coli); MutS protein homologue 2
Type:
DNA binding protein
Mass (Da):
104743
Number AA:
934
UniProt ID:
P43246
International Prot ID:
IPI00017303
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0032300
GO:0032301
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0000217
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0000018
GO:0001775
GO:0002200
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
Q
G
M
P
E
K
P
T
T
T
V
R
L
F
D
Site 2
T32
G
M
P
E
K
P
T
T
T
V
R
L
F
D
R
Site 3
T33
M
P
E
K
P
T
T
T
V
R
L
F
D
R
G
Site 4
Y43
L
F
D
R
G
D
F
Y
T
A
H
G
E
D
A
Site 5
T44
F
D
R
G
D
F
Y
T
A
H
G
E
D
A
L
Site 6
T60
A
A
R
E
V
F
K
T
Q
G
V
I
K
Y
M
Site 7
Y66
K
T
Q
G
V
I
K
Y
M
G
P
A
G
A
K
Site 8
S77
A
G
A
K
N
L
Q
S
V
V
L
S
K
M
N
Site 9
Y98
D
L
L
L
V
R
Q
Y
R
V
E
V
Y
K
N
Site 10
Y103
R
Q
Y
R
V
E
V
Y
K
N
R
A
G
N
K
Site 11
Y118
A
S
K
E
N
D
W
Y
L
A
Y
K
A
S
P
Site 12
Y121
E
N
D
W
Y
L
A
Y
K
A
S
P
G
N
L
Site 13
S124
W
Y
L
A
Y
K
A
S
P
G
N
L
S
Q
F
Site 14
S129
K
A
S
P
G
N
L
S
Q
F
E
D
I
L
F
Site 15
S153
G
V
V
G
V
K
M
S
A
V
D
G
Q
R
Q
Site 16
Y165
Q
R
Q
V
G
V
G
Y
V
D
S
I
Q
R
K
Site 17
S185
F
P
D
N
D
Q
F
S
N
L
E
A
L
L
I
Site 18
T206
C
V
L
P
G
G
E
T
A
G
D
M
G
K
L
Site 19
T225
Q
R
G
G
I
L
I
T
E
R
K
K
A
D
F
Site 20
Y238
D
F
S
T
K
D
I
Y
Q
D
L
N
R
L
L
Site 21
S255
K
K
G
E
Q
M
N
S
A
V
L
P
E
M
E
Site 22
S281
I
K
F
L
E
L
L
S
D
D
S
N
F
G
Q
Site 23
S284
L
E
L
L
S
D
D
S
N
F
G
Q
F
E
L
Site 24
T292
N
F
G
Q
F
E
L
T
T
F
D
F
S
Q
Y
Site 25
S316
A
L
N
L
F
Q
G
S
V
E
D
T
T
G
S
Site 26
T320
F
Q
G
S
V
E
D
T
T
G
S
Q
S
L
A
Site 27
T321
Q
G
S
V
E
D
T
T
G
S
Q
S
L
A
A
Site 28
S325
E
D
T
T
G
S
Q
S
L
A
A
L
L
N
K
Site 29
T335
A
L
L
N
K
C
K
T
P
Q
G
Q
R
L
V
Site 30
T375
E
D
A
E
L
R
Q
T
L
Q
E
D
L
L
R
Site 31
Y405
A
A
N
L
Q
D
C
Y
R
L
Y
Q
G
I
N
Site 32
Y408
L
Q
D
C
Y
R
L
Y
Q
G
I
N
Q
L
P
Site 33
S445
T
P
L
T
D
L
R
S
D
F
S
K
F
Q
E
Site 34
S448
T
D
L
R
S
D
F
S
K
F
Q
E
M
I
E
Site 35
T456
K
F
Q
E
M
I
E
T
T
L
D
M
D
Q
V
Site 36
S473
H
E
F
L
V
K
P
S
F
D
P
N
L
S
E
Site 37
S479
P
S
F
D
P
N
L
S
E
L
R
E
I
M
N
Site 38
S494
D
L
E
K
K
M
Q
S
T
L
I
S
A
A
R
Site 39
S515
G
K
Q
I
K
L
D
S
S
A
Q
F
G
Y
Y
Site 40
Y521
D
S
S
A
Q
F
G
Y
Y
F
R
V
T
C
K
Site 41
Y522
S
S
A
Q
F
G
Y
Y
F
R
V
T
C
K
E
Site 42
T526
F
G
Y
Y
F
R
V
T
C
K
E
E
K
V
L
Site 43
S554
N
G
V
K
F
T
N
S
K
L
T
S
L
N
E
Site 44
S558
F
T
N
S
K
L
T
S
L
N
E
E
Y
T
K
Site 45
T594
G
Y
V
E
P
M
Q
T
L
N
D
V
L
A
Q
Site 46
Y656
A
F
I
P
N
D
V
Y
F
E
K
D
K
Q
M
Site 47
S676
G
P
N
M
G
G
K
S
T
Y
I
R
Q
T
G
Site 48
T677
P
N
M
G
G
K
S
T
Y
I
R
Q
T
G
V
Site 49
Y678
N
M
G
G
K
S
T
Y
I
R
Q
T
G
V
I
Site 50
S717
A
R
V
G
A
G
D
S
Q
L
K
G
V
S
T
Site 51
T732
F
M
A
E
M
L
E
T
A
S
I
L
R
S
A
Site 52
S734
A
E
M
L
E
T
A
S
I
L
R
S
A
T
K
Site 53
S738
E
T
A
S
I
L
R
S
A
T
K
D
S
L
I
Site 54
T754
I
D
E
L
G
R
G
T
S
T
Y
D
G
F
G
Site 55
S755
D
E
L
G
R
G
T
S
T
Y
D
G
F
G
L
Site 56
T756
E
L
G
R
G
T
S
T
Y
D
G
F
G
L
A
Site 57
Y757
L
G
R
G
T
S
T
Y
D
G
F
G
L
A
W
Site 58
T812
L
T
T
E
E
T
L
T
M
L
Y
Q
V
K
K
Site 59
Y815
E
E
T
L
T
M
L
Y
Q
V
K
K
G
V
C
Site 60
S825
K
K
G
V
C
D
Q
S
F
G
I
H
V
A
E
Site 61
Y856
L
E
L
E
E
F
Q
Y
I
G
E
S
Q
G
Y
Site 62
S860
E
F
Q
Y
I
G
E
S
Q
G
Y
D
I
M
E
Site 63
Y863
Y
I
G
E
S
Q
G
Y
D
I
M
E
P
A
A
Site 64
Y874
E
P
A
A
K
K
C
Y
L
E
R
E
Q
G
E
Site 65
S889
K
I
I
Q
E
F
L
S
K
V
K
Q
M
P
F
Site 66
T897
K
V
K
Q
M
P
F
T
E
M
S
E
E
N
I
Site 67
S900
Q
M
P
F
T
E
M
S
E
E
N
I
T
I
K
Site 68
T905
E
M
S
E
E
N
I
T
I
K
L
K
Q
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation