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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
nAChRA4
Full Name:
Neuronal acetylcholine receptor subunit alpha-4
Alias:
ACHA4; ACRA4; BFNC; Cholinergic receptor, nicotinic, alpha 4; CHRNA4; EBN; EBN1; NACRA4; Neuronal acetylcholine receptor protein, alpha-4 chain precursor; Nicotinic acetlycholine receptor alpha 4 subunit
Type:
Receptor, misc.; Channel, ligand-gated
Mass (Da):
69957
Number AA:
627
UniProt ID:
P43681
International Prot ID:
IPI00020036
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0043025
GO:0030425
Uniprot
OncoNet
Molecular Function:
GO:0015464
GO:0004889
PhosphoSite+
KinaseNET
Biological Process:
GO:0042113
GO:0006281
GO:0035095
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
G
T
G
L
L
R
A
S
S
H
V
E
T
R
A
Site 2
S28
T
G
L
L
R
A
S
S
H
V
E
T
R
A
H
Site 3
S334
V
L
N
V
H
H
R
S
P
R
T
H
T
M
P
Site 4
T339
H
R
S
P
R
T
H
T
M
P
T
W
V
R
R
Site 5
T342
P
R
T
H
T
M
P
T
W
V
R
R
V
F
L
Site 6
S362
L
L
L
M
K
R
P
S
V
V
K
D
N
C
R
Site 7
S380
E
S
M
H
K
M
A
S
A
P
R
F
W
P
E
Site 8
T395
P
E
G
E
P
P
A
T
S
G
T
Q
S
L
H
Site 9
S396
E
G
E
P
P
A
T
S
G
T
Q
S
L
H
P
Site 10
T398
E
P
P
A
T
S
G
T
Q
S
L
H
P
P
S
Site 11
S400
P
A
T
S
G
T
Q
S
L
H
P
P
S
P
S
Site 12
S405
T
Q
S
L
H
P
P
S
P
S
F
C
V
P
L
Site 13
S421
V
P
A
E
P
G
P
S
C
K
S
P
S
D
Q
Site 14
S424
E
P
G
P
S
C
K
S
P
S
D
Q
L
P
P
Site 15
S426
G
P
S
C
K
S
P
S
D
Q
L
P
P
Q
Q
Site 16
S441
P
L
E
A
E
K
A
S
P
H
P
S
P
G
P
Site 17
S445
E
K
A
S
P
H
P
S
P
G
P
C
R
P
P
Site 18
T455
P
C
R
P
P
H
G
T
Q
A
P
G
L
A
K
Site 19
S465
P
G
L
A
K
A
R
S
L
S
V
Q
H
M
S
Site 20
S467
L
A
K
A
R
S
L
S
V
Q
H
M
S
S
P
Site 21
S473
L
S
V
Q
H
M
S
S
P
G
E
A
V
E
G
Site 22
S486
E
G
G
V
R
C
R
S
R
S
I
Q
Y
C
V
Site 23
S488
G
V
R
C
R
S
R
S
I
Q
Y
C
V
P
R
Site 24
Y491
C
R
S
R
S
I
Q
Y
C
V
P
R
D
D
A
Site 25
T515
G
A
L
A
S
R
N
T
H
S
A
E
L
P
P
Site 26
S527
L
P
P
P
D
Q
P
S
P
C
K
C
T
C
K
Site 27
S539
T
C
K
K
E
P
S
S
V
S
P
S
A
T
V
Site 28
S541
K
K
E
P
S
S
V
S
P
S
A
T
V
K
T
Site 29
S543
E
P
S
S
V
S
P
S
A
T
V
K
T
R
S
Site 30
T545
S
S
V
S
P
S
A
T
V
K
T
R
S
T
K
Site 31
S550
S
A
T
V
K
T
R
S
T
K
A
P
P
P
H
Site 32
T551
A
T
V
K
T
R
S
T
K
A
P
P
P
H
L
Site 33
S561
P
P
P
H
L
P
L
S
P
A
L
T
R
A
V
Site 34
Y573
R
A
V
E
G
V
Q
Y
I
A
D
H
L
K
A
Site 35
T583
D
H
L
K
A
E
D
T
D
F
S
V
K
E
D
Site 36
S586
K
A
E
D
T
D
F
S
V
K
E
D
W
K
Y
Site 37
Y593
S
V
K
E
D
W
K
Y
V
A
M
V
I
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation