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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MMP13
Full Name:
Collagenase 3
Alias:
CLG3; EC 3.4.24.-; Matrix metalloproteinase-13; MMP-13
Type:
Protease
Mass (Da):
53820
Number AA:
471
UniProt ID:
P45452
International Prot ID:
IPI00021738
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030574
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
G
G
D
E
D
D
L
S
E
E
D
L
Q
F
A
Site 2
Y42
D
L
Q
F
A
E
R
Y
L
R
S
Y
Y
H
P
Site 3
Y46
A
E
R
Y
L
R
S
Y
Y
H
P
T
N
L
A
Site 4
Y47
E
R
Y
L
R
S
Y
Y
H
P
T
N
L
A
G
Site 5
S73
E
R
L
R
E
M
Q
S
F
F
G
L
E
V
T
Site 6
T87
T
G
K
L
D
D
N
T
L
D
V
M
K
K
P
Site 7
Y125
L
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
Site 8
T126
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
E
Site 9
T130
V
N
Y
T
P
D
M
T
H
S
E
V
E
K
A
Site 10
S146
K
K
A
F
K
V
W
S
D
V
T
P
L
N
F
Site 11
Y176
I
K
E
H
G
D
F
Y
P
F
D
G
P
S
G
Site 12
Y195
A
F
P
P
G
P
N
Y
G
G
D
A
H
F
D
Site 13
T206
A
H
F
D
D
D
E
T
W
T
S
S
S
K
G
Site 14
S209
D
D
D
E
T
W
T
S
S
S
K
G
Y
N
L
Site 15
S210
D
D
E
T
W
T
S
S
S
K
G
Y
N
L
F
Site 16
S227
A
A
H
E
F
G
H
S
L
G
L
D
H
S
K
Site 17
S233
H
S
L
G
L
D
H
S
K
D
P
G
A
L
M
Site 18
Y244
G
A
L
M
F
P
I
Y
T
Y
T
G
K
S
H
Site 19
S264
D
D
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
Site 20
Y266
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
D
P
Site 21
T280
P
N
P
K
H
P
K
T
P
D
K
C
D
P
S
Site 22
S287
T
P
D
K
C
D
P
S
L
S
L
D
A
I
T
Site 23
S289
D
K
C
D
P
S
L
S
L
D
A
I
T
S
L
Site 24
T300
I
T
S
L
R
G
E
T
M
I
F
K
D
R
F
Site 25
S325
A
E
L
F
L
T
K
S
F
W
P
E
L
P
N
Site 26
Y338
P
N
R
I
D
A
A
Y
E
H
P
S
H
D
L
Site 27
Y360
K
F
W
A
L
N
G
Y
D
I
L
E
G
Y
P
Site 28
Y366
G
Y
D
I
L
E
G
Y
P
K
K
I
S
E
L
Site 29
T394
H
F
E
D
T
G
K
T
L
L
F
S
G
N
Q
Site 30
Y416
N
H
I
M
D
K
D
Y
P
R
L
I
E
E
D
Site 31
Y435
G
D
K
V
D
A
V
Y
E
K
N
G
Y
I
Y
Site 32
Y440
A
V
Y
E
K
N
G
Y
I
Y
F
F
N
G
P
Site 33
Y442
Y
E
K
N
G
Y
I
Y
F
F
N
G
P
I
Q
Site 34
Y452
N
G
P
I
Q
F
E
Y
S
I
W
S
N
R
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation