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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP5
Full Name:
Ubiquitin carboxyl-terminal hydrolase 5
Alias:
Deubiquitinating enzyme 5; Isopeptidase T; ISOT; Ubiquitin specific peptidase 5; Ubiquitin thioesterase 5; Ubiquitin thiolesterase 5; Ubiquitin-specific processing protease 5; Ubiquitin-specific-processing protease 5; UBP5
Type:
EC 3.1.2.15; Protease
Mass (Da):
95786
Number AA:
858
UniProt ID:
P45974
International Prot ID:
IPI00375145
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000323
GO:0005634
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0004197
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0006511
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
H
K
D
E
C
A
F
S
F
D
T
P
E
S
E
Site 2
T36
E
C
A
F
S
F
D
T
P
E
S
E
G
G
L
Site 3
S39
F
S
F
D
T
P
E
S
E
G
G
L
Y
I
C
Site 4
Y57
F
L
G
F
G
K
Q
Y
V
E
R
H
F
N
K
Site 5
T65
V
E
R
H
F
N
K
T
G
Q
R
V
Y
L
H
Site 6
Y70
N
K
T
G
Q
R
V
Y
L
H
L
R
R
T
R
Site 7
T76
V
Y
L
H
L
R
R
T
R
R
P
K
E
E
D
Site 8
T86
P
K
E
E
D
P
A
T
G
T
G
D
P
P
R
Site 9
S110
V
E
G
G
F
D
L
S
E
E
K
F
E
L
D
Site 10
S156
S
A
V
E
A
L
L
S
A
D
S
A
S
R
K
Site 11
S159
E
A
L
L
S
A
D
S
A
S
R
K
Q
E
V
Site 12
S161
L
L
S
A
D
S
A
S
R
K
Q
E
V
Q
A
Site 13
S177
D
G
E
V
R
Q
V
S
K
H
A
F
S
L
K
Site 14
S182
Q
V
S
K
H
A
F
S
L
K
Q
L
D
N
P
Site 15
T213
E
N
L
W
L
N
L
T
D
G
S
I
L
C
G
Site 16
S216
W
L
N
L
T
D
G
S
I
L
C
G
R
R
Y
Site 17
Y223
S
I
L
C
G
R
R
Y
F
D
G
S
G
G
N
Site 18
S227
G
R
R
Y
F
D
G
S
G
G
N
N
H
A
V
Site 19
T240
A
V
E
H
Y
R
E
T
G
Y
P
L
A
V
K
Site 20
Y242
E
H
Y
R
E
T
G
Y
P
L
A
V
K
L
G
Site 21
Y259
T
P
D
G
A
D
V
Y
S
Y
D
E
D
D
M
Site 22
S260
P
D
G
A
D
V
Y
S
Y
D
E
D
D
M
V
Site 23
Y261
D
G
A
D
V
Y
S
Y
D
E
D
D
M
V
L
Site 24
S271
D
D
M
V
L
D
P
S
L
A
E
H
L
S
H
Site 25
T289
D
M
L
K
M
Q
K
T
D
K
T
M
T
E
L
Site 26
T292
K
M
Q
K
T
D
K
T
M
T
E
L
E
I
D
Site 27
Y325
K
P
L
F
G
P
G
Y
T
G
I
R
N
L
G
Site 28
Y336
R
N
L
G
N
S
C
Y
L
N
S
V
V
Q
V
Site 29
Y354
I
P
D
F
Q
R
K
Y
V
D
K
L
E
K
I
Site 30
T370
Q
N
A
P
T
D
P
T
Q
D
F
S
T
Q
V
Site 31
T375
D
P
T
Q
D
F
S
T
Q
V
A
K
L
G
H
Site 32
S386
K
L
G
H
G
L
L
S
G
E
Y
S
K
P
V
Site 33
Y389
H
G
L
L
S
G
E
Y
S
K
P
V
P
E
S
Site 34
S390
G
L
L
S
G
E
Y
S
K
P
V
P
E
S
G
Site 35
S396
Y
S
K
P
V
P
E
S
G
D
G
E
R
V
P
Site 36
S429
G
K
G
H
P
E
F
S
T
N
R
Q
Q
D
A
Site 37
T430
K
G
H
P
E
F
S
T
N
R
Q
Q
D
A
Q
Site 38
S454
V
E
R
N
C
R
S
S
E
N
P
N
E
V
F
Site 39
T474
E
K
I
K
C
L
A
T
E
K
V
K
Y
T
Q
Site 40
Y479
L
A
T
E
K
V
K
Y
T
Q
R
V
D
Y
I
Site 41
T480
A
T
E
K
V
K
Y
T
Q
R
V
D
Y
I
M
Site 42
Y485
K
Y
T
Q
R
V
D
Y
I
M
Q
L
P
V
P
Site 43
Y505
N
K
E
E
L
L
E
Y
E
E
K
K
R
Q
A
Site 44
Y536
F
S
S
C
L
E
A
Y
G
A
P
E
Q
V
D
Site 45
S554
S
T
A
L
Q
A
K
S
V
A
V
K
T
T
R
Site 46
S590
V
P
K
K
L
D
V
S
I
E
M
P
E
E
L
Site 47
S600
M
P
E
E
L
D
I
S
Q
L
R
G
T
G
L
Site 48
T605
D
I
S
Q
L
R
G
T
G
L
Q
P
G
E
E
Site 49
T623
D
I
A
P
P
L
V
T
P
D
E
P
K
G
S
Site 50
S630
T
P
D
E
P
K
G
S
L
G
F
Y
G
N
E
Site 51
Y634
P
K
G
S
L
G
F
Y
G
N
E
D
E
D
S
Site 52
S641
Y
G
N
E
D
E
D
S
F
C
S
P
H
F
S
Site 53
S644
E
D
E
D
S
F
C
S
P
H
F
S
S
P
T
Site 54
S648
S
F
C
S
P
H
F
S
S
P
T
S
P
M
L
Site 55
S649
F
C
S
P
H
F
S
S
P
T
S
P
M
L
D
Site 56
S652
P
H
F
S
S
P
T
S
P
M
L
D
E
S
V
Site 57
S658
T
S
P
M
L
D
E
S
V
I
I
Q
L
V
E
Site 58
Y678
D
A
C
R
K
A
V
Y
Y
T
G
N
S
G
A
Site 59
Y679
A
C
R
K
A
V
Y
Y
T
G
N
S
G
A
E
Site 60
S710
N
P
L
I
L
P
G
S
S
G
P
G
S
T
S
Site 61
S715
P
G
S
S
G
P
G
S
T
S
A
A
A
D
P
Site 62
S717
S
S
G
P
G
S
T
S
A
A
A
D
P
P
P
Site 63
T748
A
L
K
A
L
R
A
T
N
N
S
L
E
R
A
Site 64
S751
A
L
R
A
T
N
N
S
L
E
R
A
V
D
W
Site 65
S775
A
E
A
A
M
D
I
S
E
G
R
S
A
A
D
Site 66
S779
M
D
I
S
E
G
R
S
A
A
D
S
I
S
E
Site 67
S783
E
G
R
S
A
A
D
S
I
S
E
S
V
P
V
Site 68
S785
R
S
A
A
D
S
I
S
E
S
V
P
V
G
P
Site 69
Y801
V
R
D
G
P
G
K
Y
Q
L
F
A
F
I
S
Site 70
Y819
T
S
T
M
C
G
H
Y
V
C
H
I
K
K
E
Site 71
Y832
K
E
G
R
W
V
I
Y
N
D
Q
K
V
C
A
Site 72
Y849
K
P
P
K
D
L
G
Y
I
Y
F
Y
Q
R
V
Site 73
Y851
P
K
D
L
G
Y
I
Y
F
Y
Q
R
V
A
S
Site 74
Y853
D
L
G
Y
I
Y
F
Y
Q
R
V
A
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation