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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKI67
Full Name:
Antigen KI-67
Alias:
Antigen identified by monoclonal antibody Ki-67; KI67; MKI163
Type:
Cell cycle regulation
Mass (Da):
358694
Number AA:
3256
UniProt ID:
P46013
International Prot ID:
IPI00004233
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008022
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0000074
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
W
P
T
R
R
L
V
T
I
K
R
S
G
V
D
Site 2
S13
R
L
V
T
I
K
R
S
G
V
D
G
P
H
F
Site 3
S65
A
I
L
H
N
F
S
S
T
N
P
T
Q
V
N
Site 4
T69
N
F
S
S
T
N
P
T
Q
V
N
G
S
V
I
Site 5
S74
N
P
T
Q
V
N
G
S
V
I
D
E
P
V
R
Site 6
T89
L
K
H
G
D
V
I
T
I
I
D
R
S
F
R
Site 7
S94
V
I
T
I
I
D
R
S
F
R
Y
E
N
E
S
Site 8
Y97
I
I
D
R
S
F
R
Y
E
N
E
S
L
Q
N
Site 9
S101
S
F
R
Y
E
N
E
S
L
Q
N
G
R
K
S
Site 10
S108
S
L
Q
N
G
R
K
S
T
E
F
P
R
K
I
Site 11
T109
L
Q
N
G
R
K
S
T
E
F
P
R
K
I
R
Site 12
S125
Q
E
P
A
R
R
V
S
R
S
S
F
S
S
D
Site 13
S127
P
A
R
R
V
S
R
S
S
F
S
S
D
P
D
Site 14
S128
A
R
R
V
S
R
S
S
F
S
S
D
P
D
E
Site 15
S130
R
V
S
R
S
S
F
S
S
D
P
D
E
K
A
Site 16
S131
V
S
R
S
S
F
S
S
D
P
D
E
K
A
Q
Site 17
S140
P
D
E
K
A
Q
D
S
K
A
Y
S
K
I
T
Site 18
S144
A
Q
D
S
K
A
Y
S
K
I
T
E
G
K
V
Site 19
S152
K
I
T
E
G
K
V
S
G
N
P
Q
V
H
I
Site 20
S166
I
K
N
V
K
E
D
S
T
A
D
D
S
K
D
Site 21
T167
K
N
V
K
E
D
S
T
A
D
D
S
K
D
S
Site 22
S171
E
D
S
T
A
D
D
S
K
D
S
V
A
Q
G
Site 23
S174
T
A
D
D
S
K
D
S
V
A
Q
G
T
T
N
Site 24
S184
Q
G
T
T
N
V
H
S
S
E
H
A
G
R
N
Site 25
S185
G
T
T
N
V
H
S
S
E
H
A
G
R
N
G
Site 26
S200
R
N
A
A
D
P
I
S
G
D
F
K
E
I
S
Site 27
S207
S
G
D
F
K
E
I
S
S
V
K
L
V
S
R
Site 28
S208
G
D
F
K
E
I
S
S
V
K
L
V
S
R
Y
Site 29
S220
S
R
Y
G
E
L
K
S
V
P
T
T
Q
C
L
Site 30
T224
E
L
K
S
V
P
T
T
Q
C
L
D
N
S
K
Site 31
S230
T
T
Q
C
L
D
N
S
K
K
N
E
S
P
F
Site 32
S235
D
N
S
K
K
N
E
S
P
F
W
K
L
Y
E
Site 33
Y241
E
S
P
F
W
K
L
Y
E
S
V
K
K
E
L
Site 34
S243
P
F
W
K
L
Y
E
S
V
K
K
E
L
D
V
Site 35
S252
K
K
E
L
D
V
K
S
Q
K
E
N
V
L
Q
Site 36
Y260
Q
K
E
N
V
L
Q
Y
C
R
K
S
G
L
Q
Site 37
S264
V
L
Q
Y
C
R
K
S
G
L
Q
T
D
Y
A
Site 38
T268
C
R
K
S
G
L
Q
T
D
Y
A
T
E
K
E
Site 39
Y270
K
S
G
L
Q
T
D
Y
A
T
E
K
E
S
A
Site 40
T272
G
L
Q
T
D
Y
A
T
E
K
E
S
A
D
G
Site 41
S289
G
E
T
Q
L
L
V
S
R
K
S
R
P
K
S
Site 42
S292
Q
L
L
V
S
R
K
S
R
P
K
S
G
G
S
Site 43
S296
S
R
K
S
R
P
K
S
G
G
S
G
H
A
V
Site 44
S299
S
R
P
K
S
G
G
S
G
H
A
V
A
E
P
Site 45
S308
H
A
V
A
E
P
A
S
P
E
Q
E
L
D
Q
Site 46
S325
G
K
G
R
D
V
E
S
V
Q
T
P
S
K
A
Site 47
T328
R
D
V
E
S
V
Q
T
P
S
K
A
V
G
A
Site 48
S336
P
S
K
A
V
G
A
S
F
P
L
Y
E
P
A
Site 49
Y340
V
G
A
S
F
P
L
Y
E
P
A
K
M
K
T
Site 50
T347
Y
E
P
A
K
M
K
T
P
V
Q
Y
S
Q
Q
Site 51
S352
M
K
T
P
V
Q
Y
S
Q
Q
Q
N
S
P
Q
Site 52
S357
Q
Y
S
Q
Q
Q
N
S
P
Q
K
H
K
N
K
Site 53
Y367
K
H
K
N
K
D
L
Y
T
T
G
R
R
E
S
Site 54
T368
H
K
N
K
D
L
Y
T
T
G
R
R
E
S
V
Site 55
T369
K
N
K
D
L
Y
T
T
G
R
R
E
S
V
N
Site 56
S374
Y
T
T
G
R
R
E
S
V
N
L
G
K
S
E
Site 57
S380
E
S
V
N
L
G
K
S
E
G
F
K
A
G
D
Site 58
T389
G
F
K
A
G
D
K
T
L
T
P
R
K
L
S
Site 59
T391
K
A
G
D
K
T
L
T
P
R
K
L
S
T
R
Site 60
S396
T
L
T
P
R
K
L
S
T
R
N
R
T
P
A
Site 61
T397
L
T
P
R
K
L
S
T
R
N
R
T
P
A
K
Site 62
T401
K
L
S
T
R
N
R
T
P
A
K
V
E
D
A
Site 63
S411
K
V
E
D
A
A
D
S
A
T
K
P
E
N
L
Site 64
T413
E
D
A
A
D
S
A
T
K
P
E
N
L
S
S
Site 65
S420
T
K
P
E
N
L
S
S
K
T
R
G
S
I
P
Site 66
S425
L
S
S
K
T
R
G
S
I
P
T
D
V
E
V
Site 67
T428
K
T
R
G
S
I
P
T
D
V
E
V
L
P
T
Site 68
T435
T
D
V
E
V
L
P
T
E
T
E
I
H
N
E
Site 69
T450
P
F
L
T
L
W
L
T
Q
V
E
R
K
I
Q
Site 70
S460
E
R
K
I
Q
K
D
S
L
S
K
P
E
K
L
Site 71
S462
K
I
Q
K
D
S
L
S
K
P
E
K
L
G
T
Site 72
T469
S
K
P
E
K
L
G
T
T
A
G
Q
M
C
S
Site 73
S492
D
I
N
N
F
G
D
S
I
N
E
S
E
G
I
Site 74
S496
F
G
D
S
I
N
E
S
E
G
I
P
L
K
R
Site 75
S507
P
L
K
R
R
R
V
S
F
G
G
H
L
R
P
Site 76
T525
D
E
N
L
P
P
N
T
P
L
K
R
G
E
A
Site 77
T534
L
K
R
G
E
A
P
T
K
R
K
S
L
V
M
Site 78
S538
E
A
P
T
K
R
K
S
L
V
M
H
T
P
P
Site 79
T543
R
K
S
L
V
M
H
T
P
P
V
L
K
K
I
Site 80
S558
I
K
E
Q
P
Q
P
S
G
K
Q
E
S
G
S
Site 81
S565
S
G
K
Q
E
S
G
S
E
I
H
V
E
V
K
Site 82
S575
H
V
E
V
K
A
Q
S
L
V
I
S
P
P
A
Site 83
S579
K
A
Q
S
L
V
I
S
P
P
A
P
S
P
R
Site 84
S584
V
I
S
P
P
A
P
S
P
R
K
T
P
V
A
Site 85
T588
P
A
P
S
P
R
K
T
P
V
A
S
D
Q
R
Site 86
S592
P
R
K
T
P
V
A
S
D
Q
R
R
R
S
C
Site 87
S598
A
S
D
Q
R
R
R
S
C
K
T
A
P
A
S
Site 88
T601
Q
R
R
R
S
C
K
T
A
P
A
S
S
S
K
Site 89
S605
S
C
K
T
A
P
A
S
S
S
K
S
Q
T
E
Site 90
S609
A
P
A
S
S
S
K
S
Q
T
E
V
P
K
R
Site 91
T611
A
S
S
S
K
S
Q
T
E
V
P
K
R
G
G
Site 92
S621
P
K
R
G
G
R
K
S
G
N
L
P
S
K
R
Site 93
S626
R
K
S
G
N
L
P
S
K
R
V
S
I
S
R
Site 94
S630
N
L
P
S
K
R
V
S
I
S
R
S
Q
H
D
Site 95
S632
P
S
K
R
V
S
I
S
R
S
Q
H
D
I
L
Site 96
S634
K
R
V
S
I
S
R
S
Q
H
D
I
L
Q
M
Site 97
S644
D
I
L
Q
M
I
C
S
K
R
R
S
G
A
S
Site 98
S648
M
I
C
S
K
R
R
S
G
A
S
E
A
N
L
Site 99
S651
S
K
R
R
S
G
A
S
E
A
N
L
I
V
A
Site 100
S660
A
N
L
I
V
A
K
S
W
A
D
V
V
K
L
Site 101
S684
I
K
H
G
P
Q
R
S
M
N
K
R
Q
R
R
Site 102
T694
K
R
Q
R
R
P
A
T
P
K
K
P
V
G
E
Site 103
S704
K
P
V
G
E
V
H
S
Q
F
S
T
G
H
A
Site 104
S707
G
E
V
H
S
Q
F
S
T
G
H
A
N
S
P
Site 105
T708
E
V
H
S
Q
F
S
T
G
H
A
N
S
P
C
Site 106
S713
F
S
T
G
H
A
N
S
P
C
T
I
I
I
G
Site 107
T716
G
H
A
N
S
P
C
T
I
I
I
G
K
A
H
Site 108
T761
G
I
A
E
M
F
K
T
P
V
K
E
Q
P
Q
Site 109
S780
C
H
I
A
I
S
N
S
E
N
L
L
G
K
Q
Site 110
T791
L
G
K
Q
F
Q
G
T
D
S
G
E
E
P
L
Site 111
S793
K
Q
F
Q
G
T
D
S
G
E
E
P
L
L
P
Site 112
S802
E
E
P
L
L
P
T
S
E
S
F
G
G
N
V
Site 113
S821
Q
N
A
A
K
Q
P
S
D
K
C
S
A
S
P
Site 114
S825
K
Q
P
S
D
K
C
S
A
S
P
P
L
R
R
Site 115
S827
P
S
D
K
C
S
A
S
P
P
L
R
R
Q
C
Site 116
T844
E
N
G
N
V
A
K
T
P
R
N
T
Y
K
M
Site 117
T848
V
A
K
T
P
R
N
T
Y
K
M
T
S
L
E
Site 118
Y849
A
K
T
P
R
N
T
Y
K
M
T
S
L
E
T
Site 119
T858
M
T
S
L
E
T
K
T
S
D
T
E
T
E
P
Site 120
S859
T
S
L
E
T
K
T
S
D
T
E
T
E
P
S
Site 121
T863
T
K
T
S
D
T
E
T
E
P
S
K
T
V
S
Site 122
S866
S
D
T
E
T
E
P
S
K
T
V
S
T
A
N
Site 123
T868
T
E
T
E
P
S
K
T
V
S
T
A
N
R
S
Site 124
S870
T
E
P
S
K
T
V
S
T
A
N
R
S
G
R
Site 125
T871
E
P
S
K
T
V
S
T
A
N
R
S
G
R
S
Site 126
S875
T
V
S
T
A
N
R
S
G
R
S
T
E
F
R
Site 127
T879
A
N
R
S
G
R
S
T
E
F
R
N
I
Q
K
Site 128
S893
K
L
P
V
E
S
K
S
E
E
T
N
T
E
I
Site 129
T898
S
K
S
E
E
T
N
T
E
I
V
E
C
I
L
Site 130
T912
L
K
R
G
Q
K
A
T
L
L
Q
Q
R
R
E
Site 131
Y932
I
E
R
P
F
E
T
Y
K
E
N
I
E
L
K
Site 132
T953
K
A
M
K
R
S
R
T
W
G
Q
K
C
A
P
Site 133
S962
G
Q
K
C
A
P
M
S
D
L
T
D
L
K
S
Site 134
T965
C
A
P
M
S
D
L
T
D
L
K
S
L
P
D
Site 135
S969
S
D
L
T
D
L
K
S
L
P
D
T
E
L
M
Site 136
T973
D
L
K
S
L
P
D
T
E
L
M
K
D
T
A
Site 137
T979
D
T
E
L
M
K
D
T
A
R
G
Q
N
L
L
Site 138
T988
R
G
Q
N
L
L
Q
T
Q
D
H
A
K
A
P
Site 139
S997
D
H
A
K
A
P
K
S
E
K
G
K
I
T
K
Site 140
T1003
K
S
E
K
G
K
I
T
K
M
P
C
Q
S
L
Site 141
S1009
I
T
K
M
P
C
Q
S
L
Q
P
E
P
I
N
Site 142
T1017
L
Q
P
E
P
I
N
T
P
T
H
T
K
Q
Q
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T
K
S
Q
P
A
A
S
T
L
E
S
K
S
V
Site 447
T3213
K
S
Q
P
A
A
S
T
L
E
S
K
S
V
Q
Site 448
S3216
P
A
A
S
T
L
E
S
K
S
V
Q
R
V
T
Site 449
S3218
A
S
T
L
E
S
K
S
V
Q
R
V
T
R
S
Site 450
T3223
S
K
S
V
Q
R
V
T
R
S
V
K
R
C
A
Site 451
S3225
S
V
Q
R
V
T
R
S
V
K
R
C
A
E
N
Site 452
S3249
V
K
K
I
R
T
R
S
H
R
D
S
E
D
I
Site 453
S3253
R
T
R
S
H
R
D
S
E
D
I
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation