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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHKA2
Full Name:
Phosphorylase b kinase regulatory subunit alpha, liver isoform
Alias:
KPB2; Liver isoform; PHK; Phosphorylase kinase alpha L; PYK; PYKL; XLG; XLG2
Type:
Protein-serine kinase, regulatory subunit
Mass (Da):
138408
Number AA:
1235
UniProt ID:
P46019
International Prot ID:
IPI00004237
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005964
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0004689
PhosphoSite+
KinaseNET
Biological Process:
GO:0005977
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
R
S
R
S
N
S
G
V
R
L
D
Site 2
S7
_
M
R
S
R
S
N
S
G
V
R
L
D
G
Y
Site 3
Y14
S
G
V
R
L
D
G
Y
A
R
L
V
Q
Q
T
Site 4
S34
N
P
V
T
G
L
L
S
A
S
H
E
Q
K
D
Site 5
S107
E
K
F
K
H
T
Q
S
T
K
D
S
L
H
A
Site 6
S111
H
T
Q
S
T
K
D
S
L
H
A
K
Y
N
T
Site 7
Y116
K
D
S
L
H
A
K
Y
N
T
A
T
C
G
T
Site 8
Y181
A
A
Y
K
V
A
D
Y
G
M
W
E
R
G
D
Site 9
T190
M
W
E
R
G
D
K
T
N
Q
G
I
P
E
L
Site 10
S226
G
A
H
G
G
R
K
S
V
I
H
V
L
P
D
Site 11
S250
F
S
M
L
P
R
A
S
T
S
K
E
I
D
A
Site 12
T251
S
M
L
P
R
A
S
T
S
K
E
I
D
A
G
Site 13
Y301
C
R
F
L
R
D
G
Y
K
T
P
R
E
D
P
Site 14
T303
F
L
R
D
G
Y
K
T
P
R
E
D
P
N
R
Site 15
Y313
E
D
P
N
R
L
H
Y
D
P
A
E
L
K
L
Site 16
Y384
P
N
K
V
D
E
E
Y
K
N
P
H
T
V
D
Site 17
T389
E
E
Y
K
N
P
H
T
V
D
R
V
P
M
G
Site 18
S431
D
P
L
N
R
R
F
S
T
S
V
K
P
D
V
Site 19
T432
P
L
N
R
R
F
S
T
S
V
K
P
D
V
V
Site 20
S433
L
N
R
R
F
S
T
S
V
K
P
D
V
V
V
Site 21
Y483
G
R
I
L
S
H
I
Y
A
K
L
G
R
N
K
Site 22
S495
R
N
K
N
M
N
L
S
G
R
P
Y
R
H
I
Site 23
Y499
M
N
L
S
G
R
P
Y
R
H
I
G
V
L
G
Site 24
S508
H
I
G
V
L
G
T
S
K
L
Y
V
I
R
N
Site 25
T519
V
I
R
N
Q
I
F
T
F
T
P
Q
F
T
D
Site 26
T521
R
N
Q
I
F
T
F
T
P
Q
F
T
D
Q
H
Site 27
Y531
F
T
D
Q
H
H
F
Y
L
A
L
D
N
E
M
Site 28
Y549
M
L
R
I
E
L
A
Y
L
C
T
C
W
R
M
Site 29
T561
W
R
M
T
G
R
P
T
L
T
F
P
I
S
R
Site 30
T563
M
T
G
R
P
T
L
T
F
P
I
S
R
T
M
Site 31
S567
P
T
L
T
F
P
I
S
R
T
M
L
T
N
D
Site 32
T572
P
I
S
R
T
M
L
T
N
D
G
S
D
I
H
Site 33
S580
N
D
G
S
D
I
H
S
A
V
L
S
T
I
R
Site 34
S584
D
I
H
S
A
V
L
S
T
I
R
K
L
E
D
Site 35
Y593
I
R
K
L
E
D
G
Y
F
G
G
A
R
V
K
Site 36
T617
T
S
F
Y
T
Y
L
T
F
L
D
P
D
C
D
Site 37
S632
E
K
L
F
D
N
A
S
E
G
T
F
S
P
D
Site 38
T635
F
D
N
A
S
E
G
T
F
S
P
D
S
D
S
Site 39
S637
N
A
S
E
G
T
F
S
P
D
S
D
S
D
L
Site 40
S640
E
G
T
F
S
P
D
S
D
S
D
L
V
G
Y
Site 41
S642
T
F
S
P
D
S
D
S
D
L
V
G
Y
L
E
Site 42
Y647
S
D
S
D
L
V
G
Y
L
E
D
T
C
N
Q
Site 43
T651
L
V
G
Y
L
E
D
T
C
N
Q
E
S
Q
D
Site 44
S656
E
D
T
C
N
Q
E
S
Q
D
E
L
D
H
Y
Site 45
Y663
S
Q
D
E
L
D
H
Y
I
N
H
L
L
Q
S
Site 46
S670
Y
I
N
H
L
L
Q
S
T
S
L
R
S
Y
L
Site 47
S672
N
H
L
L
Q
S
T
S
L
R
S
Y
L
P
P
Site 48
S675
L
Q
S
T
S
L
R
S
Y
L
P
P
L
C
K
Site 49
Y676
Q
S
T
S
L
R
S
Y
L
P
P
L
C
K
N
Site 50
S691
T
E
D
R
H
V
F
S
A
I
H
S
T
R
D
Site 51
S701
H
S
T
R
D
I
L
S
V
M
A
K
A
K
G
Site 52
S724
T
L
P
T
K
V
L
S
A
H
R
K
S
L
N
Site 53
S729
V
L
S
A
H
R
K
S
L
N
L
V
D
S
P
Site 54
S735
K
S
L
N
L
V
D
S
P
Q
P
L
L
E
K
Site 55
S746
L
L
E
K
V
P
E
S
D
F
Q
W
P
R
D
Site 56
S771
V
E
Q
L
K
D
C
S
N
L
Q
D
Q
A
D
Site 57
S790
L
Y
V
I
K
G
P
S
W
D
T
N
L
S
G
Site 58
T793
I
K
G
P
S
W
D
T
N
L
S
G
Q
H
G
Site 59
S796
P
S
W
D
T
N
L
S
G
Q
H
G
V
T
V
Site 60
T802
L
S
G
Q
H
G
V
T
V
Q
N
L
L
G
E
Site 61
Y811
Q
N
L
L
G
E
L
Y
G
K
A
G
L
N
Q
Site 62
Y825
Q
E
W
G
L
I
R
Y
I
S
G
L
L
R
K
Site 63
S846
E
A
C
T
D
L
L
S
H
Q
K
Q
L
T
V
Site 64
T852
L
S
H
Q
K
Q
L
T
V
G
L
P
P
E
P
Site 65
S865
E
P
R
E
K
I
I
S
A
P
L
P
P
E
E
Site 66
Y878
E
E
L
T
K
L
I
Y
E
A
S
G
Q
D
I
Site 67
S886
E
A
S
G
Q
D
I
S
I
A
V
L
T
Q
E
Site 68
S931
M
A
T
E
L
A
R
S
L
N
C
S
G
E
E
Site 69
S935
L
A
R
S
L
N
C
S
G
E
E
A
S
E
S
Site 70
S942
S
G
E
E
A
S
E
S
L
M
N
L
S
P
F
Site 71
S947
S
E
S
L
M
N
L
S
P
F
D
M
K
N
L
Site 72
S960
N
L
L
H
H
I
L
S
G
K
E
F
G
V
E
Site 73
S969
K
E
F
G
V
E
R
S
V
R
P
I
H
S
S
Site 74
S975
R
S
V
R
P
I
H
S
S
T
S
S
P
T
I
Site 75
S976
S
V
R
P
I
H
S
S
T
S
S
P
T
I
S
Site 76
T977
V
R
P
I
H
S
S
T
S
S
P
T
I
S
I
Site 77
S978
R
P
I
H
S
S
T
S
S
P
T
I
S
I
H
Site 78
S979
P
I
H
S
S
T
S
S
P
T
I
S
I
H
E
Site 79
S983
S
T
S
S
P
T
I
S
I
H
E
V
G
H
T
Site 80
T990
S
I
H
E
V
G
H
T
G
V
T
K
T
E
R
Site 81
T995
G
H
T
G
V
T
K
T
E
R
S
G
I
N
R
Site 82
S998
G
V
T
K
T
E
R
S
G
I
N
R
L
R
S
Site 83
S1005
S
G
I
N
R
L
R
S
E
M
K
Q
M
T
R
Site 84
T1011
R
S
E
M
K
Q
M
T
R
R
F
S
A
D
E
Site 85
S1015
K
Q
M
T
R
R
F
S
A
D
E
Q
F
F
S
Site 86
S1022
S
A
D
E
Q
F
F
S
V
G
Q
A
A
S
S
Site 87
S1028
F
S
V
G
Q
A
A
S
S
S
A
H
S
S
K
Site 88
S1029
S
V
G
Q
A
A
S
S
S
A
H
S
S
K
S
Site 89
S1030
V
G
Q
A
A
S
S
S
A
H
S
S
K
S
A
Site 90
S1033
A
A
S
S
S
A
H
S
S
K
S
A
R
S
S
Site 91
S1034
A
S
S
S
A
H
S
S
K
S
A
R
S
S
T
Site 92
S1036
S
S
A
H
S
S
K
S
A
R
S
S
T
P
S
Site 93
S1039
H
S
S
K
S
A
R
S
S
T
P
S
S
P
T
Site 94
S1040
S
S
K
S
A
R
S
S
T
P
S
S
P
T
G
Site 95
T1041
S
K
S
A
R
S
S
T
P
S
S
P
T
G
T
Site 96
S1043
S
A
R
S
S
T
P
S
S
P
T
G
T
S
S
Site 97
S1044
A
R
S
S
T
P
S
S
P
T
G
T
S
S
S
Site 98
T1046
S
S
T
P
S
S
P
T
G
T
S
S
S
D
S
Site 99
T1048
T
P
S
S
P
T
G
T
S
S
S
D
S
G
G
Site 100
S1049
P
S
S
P
T
G
T
S
S
S
D
S
G
G
H
Site 101
S1050
S
S
P
T
G
T
S
S
S
D
S
G
G
H
H
Site 102
S1051
S
P
T
G
T
S
S
S
D
S
G
G
H
H
I
Site 103
S1053
T
G
T
S
S
S
D
S
G
G
H
H
I
G
W
Site 104
Y1085
N
R
V
P
V
G
F
Y
Q
R
V
W
K
I
L
Site 105
Y1103
H
G
L
S
I
D
G
Y
V
L
P
S
S
T
T
Site 106
S1108
D
G
Y
V
L
P
S
S
T
T
R
E
M
T
P
Site 107
T1109
G
Y
V
L
P
S
S
T
T
R
E
M
T
P
H
Site 108
T1114
S
S
T
T
R
E
M
T
P
H
E
I
K
F
A
Site 109
S1126
K
F
A
V
H
V
E
S
V
L
N
R
V
P
Q
Site 110
Y1214
G
A
Y
G
T
M
T
Y
L
T
R
A
V
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation