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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATRX
Full Name:
Transcriptional regulator ATRX
Alias:
Alpha thalassemia/mental retardation syndrome X-linked; EC 3.6.1.-; RAD54; RAD54L; XH2; X-linked helicase II; X-linked nuclear protein; XNP; Znf-HX
Type:
Nucleus, Nuclear heterochromatin protein
Mass (Da):
282524
Number AA:
2492
UniProt ID:
P46100
International Prot ID:
IPI00220107
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005720
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003678
PhosphoSite+
KinaseNET
Biological Process:
GO:0006306
GO:0006310
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
A
E
P
M
S
E
S
K
L
N
T
L
Site 2
T13
M
S
E
S
K
L
N
T
L
V
Q
K
L
H
D
Site 3
S25
L
H
D
F
L
A
H
S
S
E
E
S
E
E
T
Site 4
S26
H
D
F
L
A
H
S
S
E
E
S
E
E
T
S
Site 5
S29
L
A
H
S
S
E
E
S
E
E
T
S
S
P
P
Site 6
T32
S
S
E
E
S
E
E
T
S
S
P
P
R
L
A
Site 7
S33
S
E
E
S
E
E
T
S
S
P
P
R
L
A
M
Site 8
S34
E
E
S
E
E
T
S
S
P
P
R
L
A
M
N
Site 9
T44
R
L
A
M
N
Q
N
T
D
K
I
S
G
S
G
Site 10
S48
N
Q
N
T
D
K
I
S
G
S
G
S
N
S
D
Site 11
S50
N
T
D
K
I
S
G
S
G
S
N
S
D
M
M
Site 12
S52
D
K
I
S
G
S
G
S
N
S
D
M
M
E
N
Site 13
S54
I
S
G
S
G
S
N
S
D
M
M
E
N
S
K
Site 14
S60
N
S
D
M
M
E
N
S
K
E
E
G
T
S
S
Site 15
S66
N
S
K
E
E
G
T
S
S
S
E
K
S
K
S
Site 16
S67
S
K
E
E
G
T
S
S
S
E
K
S
K
S
S
Site 17
S68
K
E
E
G
T
S
S
S
E
K
S
K
S
S
G
Site 18
S71
G
T
S
S
S
E
K
S
K
S
S
G
S
S
R
Site 19
S73
S
S
S
E
K
S
K
S
S
G
S
S
R
S
K
Site 20
S74
S
S
E
K
S
K
S
S
G
S
S
R
S
K
R
Site 21
S76
E
K
S
K
S
S
G
S
S
R
S
K
R
K
P
Site 22
S77
K
S
K
S
S
G
S
S
R
S
K
R
K
P
S
Site 23
S79
K
S
S
G
S
S
R
S
K
R
K
P
S
I
V
Site 24
S84
S
R
S
K
R
K
P
S
I
V
T
K
Y
V
E
Site 25
T87
K
R
K
P
S
I
V
T
K
Y
V
E
S
D
D
Site 26
Y89
K
P
S
I
V
T
K
Y
V
E
S
D
D
E
K
Site 27
S92
I
V
T
K
Y
V
E
S
D
D
E
K
P
L
D
Site 28
T102
E
K
P
L
D
D
E
T
V
N
E
D
A
S
N
Site 29
S108
E
T
V
N
E
D
A
S
N
E
N
S
E
N
D
Site 30
S112
E
D
A
S
N
E
N
S
E
N
D
I
T
M
Q
Site 31
T117
E
N
S
E
N
D
I
T
M
Q
S
L
P
K
G
Site 32
S120
E
N
D
I
T
M
Q
S
L
P
K
G
T
V
I
Site 33
S150
G
P
E
F
R
S
R
S
K
M
K
T
E
N
L
Site 34
T154
R
S
R
S
K
M
K
T
E
N
L
K
K
R
G
Site 35
Y187
H
F
Q
K
D
S
I
Y
R
H
P
S
L
Q
V
Site 36
S191
D
S
I
Y
R
H
P
S
L
Q
V
L
I
C
K
Site 37
Y204
C
K
N
C
F
K
Y
Y
M
S
D
D
I
S
R
Site 38
S210
Y
Y
M
S
D
D
I
S
R
D
S
D
G
M
D
Site 39
S213
S
D
D
I
S
R
D
S
D
G
M
D
E
Q
C
Site 40
T255
L
G
R
K
E
L
S
T
I
M
D
E
N
N
Q
Site 41
S282
D
L
V
T
A
C
N
S
V
F
E
N
L
E
Q
Site 42
S305
I
K
V
D
S
E
K
S
N
K
V
Y
E
H
T
Site 43
Y309
S
E
K
S
N
K
V
Y
E
H
T
S
R
F
S
Site 44
T312
S
N
K
V
Y
E
H
T
S
R
F
S
P
K
K
Site 45
S316
Y
E
H
T
S
R
F
S
P
K
K
T
S
S
N
Site 46
T320
S
R
F
S
P
K
K
T
S
S
N
C
N
G
E
Site 47
S322
F
S
P
K
K
T
S
S
N
C
N
G
E
E
K
Site 48
S334
E
E
K
K
L
D
D
S
C
S
G
S
V
T
Y
Site 49
S336
K
K
L
D
D
S
C
S
G
S
V
T
Y
S
Y
Site 50
S338
L
D
D
S
C
S
G
S
V
T
Y
S
Y
S
A
Site 51
S369
T
T
A
N
M
N
S
S
Y
V
K
F
L
K
Q
Site 52
Y370
T
A
N
M
N
S
S
Y
V
K
F
L
K
Q
A
Site 53
S381
L
K
Q
A
T
D
N
S
E
I
S
S
A
T
K
Site 54
S384
A
T
D
N
S
E
I
S
S
A
T
K
L
R
Q
Site 55
S385
T
D
N
S
E
I
S
S
A
T
K
L
R
Q
L
Site 56
S397
R
Q
L
K
A
F
K
S
V
L
A
D
I
K
K
Site 57
S415
A
L
E
E
D
L
N
S
E
F
R
A
M
D
A
Site 58
S460
E
K
K
D
I
S
K
S
E
A
K
L
S
R
K
Site 59
S465
S
K
S
E
A
K
L
S
R
K
Q
V
D
S
E
Site 60
S471
L
S
R
K
Q
V
D
S
E
H
M
H
Q
N
V
Site 61
T485
V
P
T
E
E
Q
R
T
N
K
S
T
G
G
E
Site 62
S488
E
E
Q
R
T
N
K
S
T
G
G
E
H
K
K
Site 63
S496
T
G
G
E
H
K
K
S
D
R
K
E
E
P
Q
Site 64
Y504
D
R
K
E
E
P
Q
Y
E
P
A
N
T
S
E
Site 65
T509
P
Q
Y
E
P
A
N
T
S
E
D
L
D
M
D
Site 66
T534
D
I
F
E
N
L
E
T
A
M
E
V
Q
S
S
Site 67
S541
T
A
M
E
V
Q
S
S
V
D
H
Q
G
D
G
Site 68
S558
G
T
E
Q
E
V
E
S
S
S
V
K
L
N
I
Site 69
S560
E
Q
E
V
E
S
S
S
V
K
L
N
I
S
S
Site 70
S566
S
S
V
K
L
N
I
S
S
K
D
N
R
G
G
Site 71
S567
S
V
K
L
N
I
S
S
K
D
N
R
G
G
I
Site 72
S576
D
N
R
G
G
I
K
S
K
T
T
A
K
V
T
Site 73
T578
R
G
G
I
K
S
K
T
T
A
K
V
T
K
E
Site 74
T591
K
E
L
Y
V
K
L
T
P
V
S
L
P
N
S
Site 75
S594
Y
V
K
L
T
P
V
S
L
P
N
S
P
I
K
Site 76
S598
T
P
V
S
L
P
N
S
P
I
K
G
A
D
C
Site 77
Y615
V
P
Q
D
K
D
G
Y
K
S
C
G
L
N
P
Site 78
S634
C
G
L
G
Q
E
N
S
D
N
E
H
L
V
E
Site 79
S645
H
L
V
E
N
E
V
S
L
L
L
E
E
S
D
Site 80
S651
V
S
L
L
L
E
E
S
D
L
R
R
S
P
R
Site 81
S656
E
E
S
D
L
R
R
S
P
R
V
K
T
T
P
Site 82
T661
R
R
S
P
R
V
K
T
T
P
L
R
R
P
T
Site 83
T662
R
S
P
R
V
K
T
T
P
L
R
R
P
T
E
Site 84
T668
T
T
P
L
R
R
P
T
E
T
N
P
V
T
S
Site 85
T670
P
L
R
R
P
T
E
T
N
P
V
T
S
N
S
Site 86
T674
P
T
E
T
N
P
V
T
S
N
S
D
E
E
C
Site 87
S675
T
E
T
N
P
V
T
S
N
S
D
E
E
C
N
Site 88
S677
T
N
P
V
T
S
N
S
D
E
E
C
N
E
T
Site 89
T684
S
D
E
E
C
N
E
T
V
K
E
K
Q
K
L
Site 90
S692
V
K
E
K
Q
K
L
S
V
P
V
R
K
K
D
Site 91
S703
R
K
K
D
K
R
N
S
S
D
S
A
I
D
N
Site 92
S704
K
K
D
K
R
N
S
S
D
S
A
I
D
N
P
Site 93
S706
D
K
R
N
S
S
D
S
A
I
D
N
P
K
P
Site 94
S719
K
P
N
K
L
P
K
S
K
Q
S
E
T
V
D
Site 95
T724
P
K
S
K
Q
S
E
T
V
D
Q
N
S
D
S
Site 96
S729
S
E
T
V
D
Q
N
S
D
S
D
E
M
L
A
Site 97
S731
T
V
D
Q
N
S
D
S
D
E
M
L
A
I
L
Site 98
S742
L
A
I
L
K
G
V
S
R
M
S
H
S
S
S
Site 99
S745
L
K
G
V
S
R
M
S
H
S
S
S
S
D
T
Site 100
S747
G
V
S
R
M
S
H
S
S
S
S
D
T
D
I
Site 101
S748
V
S
R
M
S
H
S
S
S
S
D
T
D
I
N
Site 102
S749
S
R
M
S
H
S
S
S
S
D
T
D
I
N
E
Site 103
S750
R
M
S
H
S
S
S
S
D
T
D
I
N
E
I
Site 104
T752
S
H
S
S
S
S
D
T
D
I
N
E
I
H
T
Site 105
T759
T
D
I
N
E
I
H
T
N
H
K
T
L
Y
D
Site 106
T763
E
I
H
T
N
H
K
T
L
Y
D
L
K
T
Q
Site 107
Y765
H
T
N
H
K
T
L
Y
D
L
K
T
Q
A
G
Site 108
T769
K
T
L
Y
D
L
K
T
Q
A
G
K
D
D
K
Site 109
S783
K
G
K
R
K
R
K
S
S
T
S
G
S
D
F
Site 110
S784
G
K
R
K
R
K
S
S
T
S
G
S
D
F
D
Site 111
T785
K
R
K
R
K
S
S
T
S
G
S
D
F
D
T
Site 112
S786
R
K
R
K
S
S
T
S
G
S
D
F
D
T
K
Site 113
S788
R
K
S
S
T
S
G
S
D
F
D
T
K
K
G
Site 114
T792
T
S
G
S
D
F
D
T
K
K
G
K
S
A
K
Site 115
S797
F
D
T
K
K
G
K
S
A
K
S
S
I
I
S
Site 116
S800
K
K
G
K
S
A
K
S
S
I
I
S
K
K
K
Site 117
S801
K
G
K
S
A
K
S
S
I
I
S
K
K
K
R
Site 118
S804
S
A
K
S
S
I
I
S
K
K
K
R
Q
T
Q
Site 119
T810
I
S
K
K
K
R
Q
T
Q
S
E
S
S
N
Y
Site 120
S812
K
K
K
R
Q
T
Q
S
E
S
S
N
Y
D
S
Site 121
S814
K
R
Q
T
Q
S
E
S
S
N
Y
D
S
E
L
Site 122
S815
R
Q
T
Q
S
E
S
S
N
Y
D
S
E
L
E
Site 123
Y817
T
Q
S
E
S
S
N
Y
D
S
E
L
E
K
E
Site 124
S819
S
E
S
S
N
Y
D
S
E
L
E
K
E
I
K
Site 125
S827
E
L
E
K
E
I
K
S
M
S
K
I
G
A
A
Site 126
T837
K
I
G
A
A
R
T
T
K
K
R
I
P
N
T
Site 127
T844
T
K
K
R
I
P
N
T
K
D
F
D
S
S
E
Site 128
S849
P
N
T
K
D
F
D
S
S
E
D
E
K
H
S
Site 129
S850
N
T
K
D
F
D
S
S
E
D
E
K
H
S
K
Site 130
T870
Q
G
H
K
N
L
K
T
S
Q
E
G
S
S
D
Site 131
S871
G
H
K
N
L
K
T
S
Q
E
G
S
S
D
D
Site 132
S875
L
K
T
S
Q
E
G
S
S
D
D
A
E
R
K
Site 133
S876
K
T
S
Q
E
G
S
S
D
D
A
E
R
K
Q
Site 134
T887
E
R
K
Q
E
R
E
T
F
S
S
A
E
G
T
Site 135
S889
K
Q
E
R
E
T
F
S
S
A
E
G
T
V
D
Site 136
S890
Q
E
R
E
T
F
S
S
A
E
G
T
V
D
K
Site 137
T894
T
F
S
S
A
E
G
T
V
D
K
D
T
T
I
Site 138
T899
E
G
T
V
D
K
D
T
T
I
M
E
L
R
D
Site 139
S917
K
K
Q
Q
A
S
A
S
T
D
G
V
D
K
L
Site 140
S925
T
D
G
V
D
K
L
S
G
K
E
Q
S
F
T
Site 141
S930
K
L
S
G
K
E
Q
S
F
T
S
L
E
V
R
Site 142
T932
S
G
K
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S
W
N
P
S
Y
D
I
Q
S
I
F
R
Site 295
Y2152
I
Q
S
I
F
R
V
Y
R
F
G
Q
T
K
P
Site 296
Y2161
F
G
Q
T
K
P
V
Y
V
Y
R
F
L
A
Q
Site 297
Y2176
G
T
M
E
D
K
I
Y
D
R
Q
V
T
K
Q
Site 298
T2181
K
I
Y
D
R
Q
V
T
K
Q
S
L
S
F
R
Site 299
S2184
D
R
Q
V
T
K
Q
S
L
S
F
R
V
V
D
Site 300
S2186
Q
V
T
K
Q
S
L
S
F
R
V
V
D
Q
Q
Site 301
T2200
Q
Q
V
E
R
H
F
T
M
N
E
L
T
E
L
Site 302
T2209
N
E
L
T
E
L
Y
T
F
E
P
D
L
L
D
Site 303
S2220
D
L
L
D
D
P
N
S
E
K
K
K
K
R
D
Site 304
T2228
E
K
K
K
K
R
D
T
P
M
L
P
K
D
T
Site 305
Y2251
H
K
E
H
I
V
G
Y
H
E
H
D
S
L
L
Site 306
S2256
V
G
Y
H
E
H
D
S
L
L
D
H
K
E
E
Site 307
T2267
H
K
E
E
E
E
L
T
E
E
E
R
K
A
A
Site 308
T2286
E
A
E
K
K
G
L
T
M
R
F
N
I
P
T
Site 309
T2293
T
M
R
F
N
I
P
T
G
T
N
L
P
P
V
Site 310
T2295
R
F
N
I
P
T
G
T
N
L
P
P
V
S
F
Site 311
S2301
G
T
N
L
P
P
V
S
F
N
S
Q
T
P
Y
Site 312
S2304
L
P
P
V
S
F
N
S
Q
T
P
Y
I
P
F
Site 313
T2306
P
V
S
F
N
S
Q
T
P
Y
I
P
F
N
L
Site 314
Y2308
S
F
N
S
Q
T
P
Y
I
P
F
N
L
G
A
Site 315
S2317
P
F
N
L
G
A
L
S
A
M
S
N
Q
Q
L
Site 316
S2375
Q
V
Q
A
L
A
L
S
R
Q
A
S
Q
E
L
Site 317
S2379
L
A
L
S
R
Q
A
S
Q
E
L
D
V
K
R
Site 318
Y2391
V
K
R
R
E
A
I
Y
N
D
V
L
T
K
Q
Site 319
Y2418
N
R
R
L
Q
Q
Q
Y
N
Q
Q
Q
Q
Q
Q
Site 320
Y2451
L
I
M
N
P
S
N
Y
Q
Q
I
D
M
R
G
Site 321
Y2460
Q
I
D
M
R
G
M
Y
Q
P
V
A
G
G
M
Site 322
S2481
R
A
P
P
P
M
R
S
K
N
P
G
P
S
Q
Site 323
S2487
R
S
K
N
P
G
P
S
Q
G
K
S
M
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation