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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Crk
Full Name:
Adapter molecule crk
Alias:
Adapter molecule crk; Crk-II; CRKO; P38; V-crk sarcoma virus CT10 oncogene
Type:
Adapter/scaffold protein
Mass (Da):
33831
Number AA:
304
UniProt ID:
P46108
International Prot ID:
IPI00004838
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005768
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042169
GO:0005515
GO:0019904
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0007242
GO:0006357
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
F
D
S
E
E
R
S
S
W
Y
W
G
R
L
S
Site 2
Y14
S
E
E
R
S
S
W
Y
W
G
R
L
S
R
Q
Site 3
S19
S
W
Y
W
G
R
L
S
R
Q
E
A
V
A
L
Site 4
S40
G
V
F
L
V
R
D
S
S
T
S
P
G
D
Y
Site 5
S41
V
F
L
V
R
D
S
S
T
S
P
G
D
Y
V
Site 6
T42
F
L
V
R
D
S
S
T
S
P
G
D
Y
V
L
Site 7
S43
L
V
R
D
S
S
T
S
P
G
D
Y
V
L
S
Site 8
Y47
S
S
T
S
P
G
D
Y
V
L
S
V
S
E
N
Site 9
S50
S
P
G
D
Y
V
L
S
V
S
E
N
S
R
V
Site 10
S52
G
D
Y
V
L
S
V
S
E
N
S
R
V
S
H
Site 11
S58
V
S
E
N
S
R
V
S
H
Y
I
I
N
S
S
Site 12
Y60
E
N
S
R
V
S
H
Y
I
I
N
S
S
G
P
Site 13
S64
V
S
H
Y
I
I
N
S
S
G
P
R
P
P
V
Site 14
S65
S
H
Y
I
I
N
S
S
G
P
R
P
P
V
P
Site 15
S74
P
R
P
P
V
P
P
S
P
A
Q
P
P
P
G
Site 16
S83
A
Q
P
P
P
G
V
S
P
S
R
L
R
I
G
Site 17
S85
P
P
P
G
V
S
P
S
R
L
R
I
G
D
Q
Site 18
S96
I
G
D
Q
E
F
D
S
L
P
A
L
L
E
F
Site 19
Y108
L
E
F
Y
K
I
H
Y
L
D
T
T
T
L
I
Site 20
T112
K
I
H
Y
L
D
T
T
T
L
I
E
P
V
S
Site 21
T113
I
H
Y
L
D
T
T
T
L
I
E
P
V
S
R
Site 22
S119
T
T
L
I
E
P
V
S
R
S
R
Q
G
S
G
Site 23
S121
L
I
E
P
V
S
R
S
R
Q
G
S
G
V
I
Site 24
S125
V
S
R
S
R
Q
G
S
G
V
I
L
R
Q
E
Site 25
Y136
L
R
Q
E
E
A
E
Y
V
R
A
L
F
D
F
Site 26
Y186
R
G
M
I
P
V
P
Y
V
E
K
Y
R
P
A
Site 27
Y190
P
V
P
Y
V
E
K
Y
R
P
A
S
A
S
V
Site 28
S194
V
E
K
Y
R
P
A
S
A
S
V
S
A
L
I
Site 29
S196
K
Y
R
P
A
S
A
S
V
S
A
L
I
G
G
Site 30
S198
R
P
A
S
A
S
V
S
A
L
I
G
G
N
Q
Site 31
S208
I
G
G
N
Q
E
G
S
H
P
Q
P
L
G
G
Site 32
Y221
G
G
P
E
P
G
P
Y
A
Q
P
S
V
N
T
Site 33
S225
P
G
P
Y
A
Q
P
S
V
N
T
P
L
P
N
Site 34
T228
Y
A
Q
P
S
V
N
T
P
L
P
N
L
Q
N
Site 35
Y239
N
L
Q
N
G
P
I
Y
A
R
V
I
Q
K
R
Site 36
Y251
Q
K
R
V
P
N
A
Y
D
K
T
A
L
A
L
Site 37
T254
V
P
N
A
Y
D
K
T
A
L
A
L
E
V
G
Site 38
T289
K
R
G
H
F
P
F
T
H
V
R
L
L
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation