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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTIF2
Full Name:
Translation initiation factor IF-2, mitochondrial
Alias:
IF2M; IF-2Mt
Type:
Protein synthesis initiation protein
Mass (Da):
81317
Number AA:
727
UniProt ID:
P46199
International Prot ID:
IPI00005039
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005739
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006412
GO:0006413
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
E
N
L
L
R
F
H
T
I
Y
R
Q
L
H
S
Site 2
S23
T
I
Y
R
Q
L
H
S
L
C
Q
R
R
A
L
Site 3
Y41
R
H
G
F
S
S
A
Y
P
V
W
T
A
Q
L
Site 4
T59
P
W
P
T
D
V
L
T
G
A
A
L
S
Q
Y
Site 5
Y66
T
G
A
A
L
S
Q
Y
R
L
L
V
T
K
K
Site 6
S80
K
E
E
G
P
W
K
S
Q
L
S
S
T
K
S
Site 7
S83
G
P
W
K
S
Q
L
S
S
T
K
S
K
K
V
Site 8
S84
P
W
K
S
Q
L
S
S
T
K
S
K
K
V
V
Site 9
S87
S
Q
L
S
S
T
K
S
K
K
V
V
E
V
W
Site 10
Y112
A
M
E
K
N
T
D
Y
V
Y
E
A
L
L
N
Site 11
Y114
E
K
N
T
D
Y
V
Y
E
A
L
L
N
T
D
Site 12
S126
N
T
D
I
D
I
D
S
L
E
A
D
S
H
L
Site 13
S131
I
D
S
L
E
A
D
S
H
L
D
E
V
W
I
Site 14
T177
Q
A
D
P
A
L
L
T
P
R
S
P
V
V
T
Site 15
T184
T
P
R
S
P
V
V
T
I
M
G
H
V
D
H
Site 16
T203
L
L
D
K
F
R
K
T
Q
V
A
A
V
E
T
Site 17
T231
L
P
S
G
E
K
I
T
F
L
D
T
P
G
H
Site 18
T235
E
K
I
T
F
L
D
T
P
G
H
A
A
F
S
Site 19
T269
D
D
G
V
M
K
Q
T
V
E
S
I
Q
H
A
Site 20
Y307
V
K
K
E
L
L
A
Y
D
V
V
C
E
D
Y
Site 21
Y314
Y
D
V
V
C
E
D
Y
G
G
D
V
Q
A
V
Site 22
T358
P
N
G
P
V
E
G
T
V
I
E
S
F
T
D
Site 23
S362
V
E
G
T
V
I
E
S
F
T
D
K
G
R
G
Site 24
T373
K
G
R
G
L
V
T
T
A
I
I
Q
R
G
T
Site 25
S385
R
G
T
L
R
K
G
S
V
L
V
A
G
K
C
Site 26
T406
M
F
D
E
N
G
K
T
I
D
E
A
Y
P
S
Site 27
Y411
G
K
T
I
D
E
A
Y
P
S
M
P
V
G
I
Site 28
S413
T
I
D
E
A
Y
P
S
M
P
V
G
I
T
G
Site 29
T419
P
S
M
P
V
G
I
T
G
W
R
D
L
P
S
Site 30
S426
T
G
W
R
D
L
P
S
A
G
E
E
I
L
E
Site 31
S436
E
E
I
L
E
V
E
S
E
P
R
A
R
E
V
Site 32
Y449
E
V
V
D
W
R
K
Y
E
Q
E
Q
E
K
G
Site 33
Y481
H
Q
K
A
R
E
K
Y
G
H
L
L
W
K
K
Site 34
S490
H
L
L
W
K
K
R
S
I
L
R
F
L
E
R
Site 35
S513
K
E
K
R
E
R
D
S
N
V
L
S
V
I
I
Site 36
S517
E
R
D
S
N
V
L
S
V
I
I
K
G
D
V
Site 37
Y538
I
L
N
I
I
D
T
Y
D
A
S
H
E
C
E
Site 38
S541
I
I
D
T
Y
D
A
S
H
E
C
E
L
E
L
Site 39
S585
A
G
N
V
I
Q
Q
S
A
A
K
K
G
V
K
Site 40
S611
E
D
L
Q
E
E
L
S
S
R
L
P
C
A
V
Site 41
S612
D
L
Q
E
E
L
S
S
R
L
P
C
A
V
E
Site 42
S633
A
S
I
L
A
T
F
S
V
T
E
G
K
K
K
Site 43
S672
G
H
V
I
W
K
G
S
L
T
S
L
K
H
H
Site 44
T688
D
D
I
S
I
V
K
T
G
M
D
C
G
L
S
Site 45
S695
T
G
M
D
C
G
L
S
L
D
E
D
N
M
E
Site 46
Y712
V
G
D
R
I
V
C
Y
E
E
K
Q
I
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation