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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NSF
Full Name:
Vesicle-fusing ATPase
Alias:
EC 3.6.4.6; SKD2; Vesicle-fusing ATPase; Vesicular-fusion protein NSF
Type:
EC 3.6.4.6; Vesicle protein; Adaptor/scaffold; Protease
Mass (Da):
82594
Number AA:
744
UniProt ID:
P46459
International Prot ID:
IPI00006451
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004176
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0006508
GO:0045184
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
M
Q
A
A
R
C
P
T
D
E
L
S
L
T
N
Site 2
T19
P
T
D
E
L
S
L
T
N
C
A
V
V
N
E
Site 3
Y45
R
T
S
P
N
H
R
Y
T
F
T
L
K
T
H
Site 4
T46
T
S
P
N
H
R
Y
T
F
T
L
K
T
H
P
Site 5
T48
P
N
H
R
Y
T
F
T
L
K
T
H
P
S
V
Site 6
T51
R
Y
T
F
T
L
K
T
H
P
S
V
V
P
G
Site 7
S63
V
P
G
S
I
A
F
S
L
P
Q
R
K
W
A
Site 8
S81
I
G
Q
E
I
E
V
S
L
Y
T
F
D
K
A
Site 9
Y83
Q
E
I
E
V
S
L
Y
T
F
D
K
A
K
Q
Site 10
T84
E
I
E
V
S
L
Y
T
F
D
K
A
K
Q
C
Site 11
S106
I
D
F
L
Q
K
K
S
I
D
S
N
P
Y
D
Site 12
S158
D
I
E
A
M
D
P
S
I
L
K
G
E
P
A
Site 13
S207
K
T
K
E
N
R
Q
S
I
I
N
P
D
W
N
Site 14
S228
G
G
L
D
K
E
F
S
D
I
F
R
R
A
F
Site 15
Y259
H
V
K
G
I
L
L
Y
G
P
P
G
C
G
K
Site 16
T267
G
P
P
G
C
G
K
T
L
L
A
R
Q
I
G
Site 17
Y294
G
P
E
I
L
N
K
Y
V
G
E
S
E
A
N
Site 18
S298
L
N
K
Y
V
G
E
S
E
A
N
I
R
K
L
Site 19
S339
A
I
C
K
Q
R
G
S
M
A
G
S
T
G
V
Site 20
S343
Q
R
G
S
M
A
G
S
T
G
V
H
D
T
V
Site 21
T349
G
S
T
G
V
H
D
T
V
V
N
Q
L
L
S
Site 22
S356
T
V
V
N
Q
L
L
S
K
I
D
G
V
E
Q
Site 23
T411
L
Q
I
L
H
I
H
T
A
R
M
R
G
H
Q
Site 24
T451
L
V
R
A
A
Q
S
T
A
M
N
R
H
I
K
Site 25
S472
V
D
M
E
K
A
E
S
L
Q
V
T
R
G
D
Site 26
T476
K
A
E
S
L
Q
V
T
R
G
D
F
L
A
S
Site 27
S483
T
R
G
D
F
L
A
S
L
E
N
D
I
K
P
Site 28
Y499
F
G
T
N
Q
E
D
Y
A
S
Y
I
M
N
G
Site 29
Y502
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Site 30
T515
I
K
W
G
D
P
V
T
R
V
L
D
D
G
E
Site 31
S531
L
V
Q
Q
T
K
N
S
D
R
T
P
L
V
S
Site 32
T534
Q
T
K
N
S
D
R
T
P
L
V
S
V
L
L
Site 33
S538
S
D
R
T
P
L
V
S
V
L
L
E
G
P
P
Site 34
S547
L
L
E
G
P
P
H
S
G
K
T
A
L
A
A
Site 35
S569
F
P
F
I
K
I
C
S
P
D
K
M
I
G
F
Site 36
S577
P
D
K
M
I
G
F
S
E
T
A
K
C
Q
A
Site 37
Y593
K
K
I
F
D
D
A
Y
K
S
Q
L
S
C
V
Site 38
Y611
D
I
E
R
L
L
D
Y
V
P
I
G
P
R
F
Site 39
T693
F
K
D
K
E
R
T
T
I
A
Q
Q
V
K
G
Site 40
Y724
S
L
Q
M
D
P
E
Y
R
V
R
K
F
L
A
Site 41
S739
L
L
R
E
E
G
A
S
P
L
D
F
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation