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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOTCH1
Full Name:
Neurogenic locus notch homolog protein 1
Alias:
neurogenic locus notch 1; NOTC1; notch 1 (translocation-associated); Notch 1, translocation-associated; Notch homolog 1, translocation-associated (Drosophila) (TAN1); Notch1; TAN1; translocation-associated notch protein TAN-1
Type:
Transcription factor; Receptor, misc.
Mass (Da):
272505
Number AA:
2555
UniProt ID:
P46531
International Prot ID:
IPI00412982
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0045662
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Neurogenic locus notch homologue protein 1 pan-specific antibody AB-NN298-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN298-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S1757
V
G
C
G
V
L
L
S
R
K
R
R
R
Q
H
Site 2
S1776
F
P
E
G
F
K
V
S
E
A
S
K
K
K
R
Site 3
S1791
R
E
P
L
G
E
D
S
V
G
L
K
P
L
K
Site 4
T1820
W
G
D
E
D
L
E
T
K
K
F
R
F
E
E
Site 5
S1856
D
A
A
D
L
R
M
S
A
M
A
P
T
P
P
Site 6
T1861
R
M
S
A
M
A
P
T
P
P
Q
G
E
V
D
Site 7
T1897
C
S
G
G
G
L
E
T
G
N
S
E
E
E
E
Site 8
S1900
G
G
L
E
T
G
N
S
E
E
E
E
D
A
P
Site 9
S1919
D
F
I
Y
Q
G
A
S
L
H
N
Q
T
D
R
Site 10
T1927
L
H
N
Q
T
D
R
T
G
E
T
A
L
H
L
Site 11
T1930
Q
T
D
R
T
G
E
T
A
L
H
L
A
A
R
Site 12
S1939
L
H
L
A
A
R
Y
S
R
S
D
A
A
K
R
Site 13
S1951
A
K
R
L
L
E
A
S
A
D
A
N
I
Q
D
Site 14
T1963
I
Q
D
N
M
G
R
T
P
L
H
A
A
V
S
Site 15
T1986
I
L
I
R
N
R
A
T
D
L
D
A
R
M
H
Site 16
T1997
A
R
M
H
D
G
T
T
P
L
I
L
A
A
R
Site 17
T2063
M
Q
N
N
R
E
E
T
P
L
F
L
A
A
R
Site 18
Y2116
I
V
R
L
L
D
E
Y
N
L
V
R
S
P
Q
Site 19
S2121
D
E
Y
N
L
V
R
S
P
Q
L
H
G
A
P
Site 20
T2132
H
G
A
P
L
G
G
T
P
T
L
S
P
P
L
Site 21
S2136
L
G
G
T
P
T
L
S
P
P
L
C
S
P
N
Site 22
S2141
T
L
S
P
P
L
C
S
P
N
G
Y
L
G
S
Site 23
Y2145
P
L
C
S
P
N
G
Y
L
G
S
L
K
P
G
Site 24
S2148
S
P
N
G
Y
L
G
S
L
K
P
G
V
Q
G
Site 25
S2162
G
K
K
V
R
K
P
S
S
K
G
L
A
C
G
Site 26
S2163
K
K
V
R
K
P
S
S
K
G
L
A
C
G
S
Site 27
S2183
L
K
A
R
R
K
K
S
Q
D
G
K
G
C
L
Site 28
S2198
L
D
S
S
G
M
L
S
P
V
D
S
L
E
S
Site 29
S2202
G
M
L
S
P
V
D
S
L
E
S
P
H
G
Y
Site 30
S2205
S
P
V
D
S
L
E
S
P
H
G
Y
L
S
D
Site 31
Y2209
S
L
E
S
P
H
G
Y
L
S
D
V
A
S
P
Site 32
S2211
E
S
P
H
G
Y
L
S
D
V
A
S
P
P
L
Site 33
S2221
A
S
P
P
L
L
P
S
P
F
Q
Q
S
P
S
Site 34
S2226
L
P
S
P
F
Q
Q
S
P
S
V
P
L
N
H
Site 35
S2228
S
P
F
Q
Q
S
P
S
V
P
L
N
H
L
P
Site 36
T2240
H
L
P
G
M
P
D
T
H
L
G
I
G
H
L
Site 37
T2268
G
G
R
L
A
F
E
T
G
P
P
R
L
S
H
Site 38
S2274
E
T
G
P
P
R
L
S
H
L
P
V
A
S
G
Site 39
S2303
F
T
V
G
G
S
T
S
L
N
G
Q
C
E
W
Site 40
S2316
E
W
L
S
R
L
Q
S
G
M
V
P
N
Q
Y
Site 41
Y2323
S
G
M
V
P
N
Q
Y
N
P
L
R
G
S
V
Site 42
S2329
Q
Y
N
P
L
R
G
S
V
A
P
G
P
L
S
Site 43
S2336
S
V
A
P
G
P
L
S
T
Q
A
P
S
L
Q
Site 44
T2337
V
A
P
G
P
L
S
T
Q
A
P
S
L
Q
H
Site 45
S2341
P
L
S
T
Q
A
P
S
L
Q
H
G
M
V
G
Site 46
S2364
S
A
L
S
Q
M
M
S
Y
Q
G
L
P
S
T
Site 47
S2370
M
S
Y
Q
G
L
P
S
T
R
L
A
T
Q
P
Site 48
T2375
L
P
S
T
R
L
A
T
Q
P
H
L
V
Q
T
Site 49
S2407
A
N
I
Q
Q
Q
Q
S
L
Q
P
P
P
P
P
Site 50
S2422
P
Q
P
H
L
G
V
S
S
A
A
S
G
H
L
Site 51
S2423
Q
P
H
L
G
V
S
S
A
A
S
G
H
L
G
Site 52
S2432
A
S
G
H
L
G
R
S
F
L
S
G
E
P
S
Site 53
S2435
H
L
G
R
S
F
L
S
G
E
P
S
Q
A
D
Site 54
S2439
S
F
L
S
G
E
P
S
Q
A
D
V
Q
P
L
Site 55
T2455
P
S
S
L
A
V
H
T
I
L
P
Q
E
S
P
Site 56
S2461
H
T
I
L
P
Q
E
S
P
A
L
P
T
S
L
Site 57
T2466
Q
E
S
P
A
L
P
T
S
L
P
S
S
L
V
Site 58
S2467
E
S
P
A
L
P
T
S
L
P
S
S
L
V
P
Site 59
T2483
V
T
A
A
Q
F
L
T
P
P
S
Q
H
S
Y
Site 60
S2486
A
Q
F
L
T
P
P
S
Q
H
S
Y
S
S
P
Site 61
S2489
L
T
P
P
S
Q
H
S
Y
S
S
P
V
D
N
Site 62
Y2490
T
P
P
S
Q
H
S
Y
S
S
P
V
D
N
T
Site 63
S2491
P
P
S
Q
H
S
Y
S
S
P
V
D
N
T
P
Site 64
S2492
P
S
Q
H
S
Y
S
S
P
V
D
N
T
P
S
Site 65
T2497
Y
S
S
P
V
D
N
T
P
S
H
Q
L
Q
V
Site 66
T2511
V
P
E
H
P
F
L
T
P
S
P
E
S
P
D
Site 67
S2513
E
H
P
F
L
T
P
S
P
E
S
P
D
Q
W
Site 68
S2516
F
L
T
P
S
P
E
S
P
D
Q
W
S
S
S
Site 69
S2521
P
E
S
P
D
Q
W
S
S
S
S
P
H
S
N
Site 70
S2522
P
E
S
P
D
Q
W
S
S
S
S
P
H
S
N
Site 71
S2523
E
S
P
D
Q
W
S
S
S
S
P
H
S
N
V
Site 72
S2524
S
P
D
Q
W
S
S
S
S
P
H
S
N
V
S
Site 73
S2527
W
S
S
S
S
P
H
S
N
V
S
D
W
S
E
Site 74
S2530
S
S
P
H
S
N
V
S
D
W
S
E
G
V
S
Site 75
S2533
H
S
N
V
S
D
W
S
E
G
V
S
S
P
P
Site 76
S2537
S
D
W
S
E
G
V
S
S
P
P
T
S
M
Q
Site 77
S2538
D
W
S
E
G
V
S
S
P
P
T
S
M
Q
S
Site 78
T2541
E
G
V
S
S
P
P
T
S
M
Q
S
Q
I
A
Site 79
S2542
G
V
S
S
P
P
T
S
M
Q
S
Q
I
A
R
Site 80
S2545
S
P
P
T
S
M
Q
S
Q
I
A
R
I
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation