KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
BRCC3
Full Name:
Lys-63-specific deubiquitinase BRCC36
Alias:
BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex, subunit 3; BRCC36; C6.1A; CXorf53; EC 3.1.2.15; Lys-63-specific deubiquitinase BRCC36
Type:
Ubiquitin conjugating system
Mass (Da):
36072
Number AA:
316
UniProt ID:
P46736
International Prot ID:
IPI00853631
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070531
GO:0070552
GO:0000152
Uniprot
OncoNet
Molecular Function:
GO:0030234
GO:0008237
GO:0031593
PhosphoSite+
KinaseNET
Biological Process:
GO:0031572
GO:0006302
GO:0070537
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
V
C
L
N
H
A
L
S
T
E
K
E
E
V
M
Site 2
T46
I
G
E
L
N
D
D
T
R
S
D
S
K
F
A
Site 3
S48
E
L
N
D
D
T
R
S
D
S
K
F
A
Y
T
Site 4
S50
N
D
D
T
R
S
D
S
K
F
A
Y
T
G
T
Site 5
Y54
R
S
D
S
K
F
A
Y
T
G
T
E
M
R
T
Site 6
S83
S
V
I
I
L
R
R
S
D
K
R
K
D
R
V
Site 7
S93
R
K
D
R
V
E
I
S
P
E
Q
L
S
A
A
Site 8
S98
E
I
S
P
E
Q
L
S
A
A
S
T
E
A
E
Site 9
T102
E
Q
L
S
A
A
S
T
E
A
E
R
L
A
E
Site 10
T111
A
E
R
L
A
E
L
T
G
R
P
M
R
V
V
Site 11
Y142
D
V
R
T
Q
A
M
Y
Q
M
M
D
Q
G
F
Site 12
T163
C
F
I
E
D
K
N
T
K
T
G
R
V
L
Y
Site 13
T165
I
E
D
K
N
T
K
T
G
R
V
L
Y
T
C
Site 14
Y170
T
K
T
G
R
V
L
Y
T
C
F
Q
S
I
Q
Site 15
T171
K
T
G
R
V
L
Y
T
C
F
Q
S
I
Q
A
Site 16
S181
Q
S
I
Q
A
Q
K
S
S
E
S
L
H
G
P
Site 17
S182
S
I
Q
A
Q
K
S
S
E
S
L
H
G
P
R
Site 18
S184
Q
A
Q
K
S
S
E
S
L
H
G
P
R
D
F
Site 19
S193
H
G
P
R
D
F
W
S
S
S
Q
H
I
S
I
Site 20
S194
G
P
R
D
F
W
S
S
S
Q
H
I
S
I
E
Site 21
S195
P
R
D
F
W
S
S
S
Q
H
I
S
I
E
G
Site 22
S199
W
S
S
S
Q
H
I
S
I
E
G
Q
K
E
E
Site 23
Y209
G
Q
K
E
E
E
R
Y
E
R
I
E
I
P
I
Site 24
S231
I
G
K
V
C
L
E
S
A
V
E
L
P
K
I
Site 25
Y247
C
Q
E
E
Q
D
A
Y
R
R
I
H
S
L
T
Site 26
S252
D
A
Y
R
R
I
H
S
L
T
H
L
D
S
V
Site 27
T254
Y
R
R
I
H
S
L
T
H
L
D
S
V
T
K
Site 28
S258
H
S
L
T
H
L
D
S
V
T
K
I
H
N
G
Site 29
T260
L
T
H
L
D
S
V
T
K
I
H
N
G
S
V
Site 30
S314
E
L
M
Q
E
L
S
S
L
E
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation