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Updated November 2019
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Protein Info
Short Name:
NEDD4
Full Name:
E3 ubiquitin-protein ligase NEDD4
Alias:
KIAA0093; MGC176705; NEDD4-1; neural precursor cell expressed, developmentally down-regulated 4; receptor-potentiating factor 1; RPF1
Type:
Ubiquitin conjugating system; Ubiquitin ligase; Ligase; Nuclear receptor co-regulator; EC 6.3.2.-
Mass (Da):
149059
Number AA:
1319
UniProt ID:
P46934
International Prot ID:
IPI00009322
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016327
GO:0005938
GO:0000785
Uniprot
OncoNet
Molecular Function:
GO:0070063
GO:0031698
GO:0050815
PhosphoSite+
KinaseNET
Biological Process:
GO:0044111
GO:0042921
GO:0010766
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
H
F
A
A
R
R
S
N
T
Y
P
L
S
E
Site 2
T16
F
A
A
R
R
S
N
T
Y
P
L
S
E
T
S
Site 3
Y17
A
A
R
R
S
N
T
Y
P
L
S
E
T
S
G
Site 4
S20
R
S
N
T
Y
P
L
S
E
T
S
G
D
D
L
Site 5
S42
F
K
R
P
T
R
I
S
T
S
N
V
V
Q
M
Site 6
T43
K
R
P
T
R
I
S
T
S
N
V
V
Q
M
K
Site 7
S44
R
P
T
R
I
S
T
S
N
V
V
Q
M
K
L
Site 8
T52
N
V
V
Q
M
K
L
T
P
R
Q
T
A
L
A
Site 9
S68
L
I
K
E
N
V
Q
S
Q
E
R
S
S
V
P
Site 10
S72
N
V
Q
S
Q
E
R
S
S
V
P
S
S
E
N
Site 11
S73
V
Q
S
Q
E
R
S
S
V
P
S
S
E
N
V
Site 12
S76
Q
E
R
S
S
V
P
S
S
E
N
V
N
K
K
Site 13
S77
E
R
S
S
V
P
S
S
E
N
V
N
K
K
S
Site 14
S84
S
E
N
V
N
K
K
S
S
C
L
Q
I
S
L
Site 15
S90
K
S
S
C
L
Q
I
S
L
Q
P
T
R
Y
S
Site 16
T94
L
Q
I
S
L
Q
P
T
R
Y
S
G
Y
L
Q
Site 17
S97
S
L
Q
P
T
R
Y
S
G
Y
L
Q
S
S
N
Site 18
Y99
Q
P
T
R
Y
S
G
Y
L
Q
S
S
N
V
L
Site 19
S102
R
Y
S
G
Y
L
Q
S
S
N
V
L
A
D
S
Site 20
S109
S
S
N
V
L
A
D
S
D
D
A
S
F
T
C
Site 21
S113
L
A
D
S
D
D
A
S
F
T
C
I
L
K
D
Site 22
S125
L
K
D
G
I
Y
S
S
A
V
V
D
N
E
L
Site 23
S143
N
D
G
H
L
V
S
S
P
A
I
C
S
G
S
Site 24
S150
S
P
A
I
C
S
G
S
L
S
N
F
S
T
S
Site 25
S152
A
I
C
S
G
S
L
S
N
F
S
T
S
D
N
Site 26
S155
S
G
S
L
S
N
F
S
T
S
D
N
G
S
Y
Site 27
T156
G
S
L
S
N
F
S
T
S
D
N
G
S
Y
S
Site 28
S157
S
L
S
N
F
S
T
S
D
N
G
S
Y
S
S
Site 29
S161
F
S
T
S
D
N
G
S
Y
S
S
N
G
S
D
Site 30
Y162
S
T
S
D
N
G
S
Y
S
S
N
G
S
D
F
Site 31
S163
T
S
D
N
G
S
Y
S
S
N
G
S
D
F
G
Site 32
S164
S
D
N
G
S
Y
S
S
N
G
S
D
F
G
S
Site 33
S167
G
S
Y
S
S
N
G
S
D
F
G
S
C
A
S
Site 34
S171
S
N
G
S
D
F
G
S
C
A
S
I
T
S
G
Site 35
S174
S
D
F
G
S
C
A
S
I
T
S
G
G
S
Y
Site 36
T176
F
G
S
C
A
S
I
T
S
G
G
S
Y
T
N
Site 37
S177
G
S
C
A
S
I
T
S
G
G
S
Y
T
N
S
Site 38
S180
A
S
I
T
S
G
G
S
Y
T
N
S
V
I
S
Site 39
Y181
S
I
T
S
G
G
S
Y
T
N
S
V
I
S
D
Site 40
T182
I
T
S
G
G
S
Y
T
N
S
V
I
S
D
S
Site 41
S184
S
G
G
S
Y
T
N
S
V
I
S
D
S
S
S
Site 42
S187
S
Y
T
N
S
V
I
S
D
S
S
S
Y
T
F
Site 43
S189
T
N
S
V
I
S
D
S
S
S
Y
T
F
P
P
Site 44
S190
N
S
V
I
S
D
S
S
S
Y
T
F
P
P
S
Site 45
S191
S
V
I
S
D
S
S
S
Y
T
F
P
P
S
D
Site 46
Y192
V
I
S
D
S
S
S
Y
T
F
P
P
S
D
D
Site 47
T193
I
S
D
S
S
S
Y
T
F
P
P
S
D
D
T
Site 48
S197
S
S
Y
T
F
P
P
S
D
D
T
F
L
G
G
Site 49
T200
T
F
P
P
S
D
D
T
F
L
G
G
N
L
P
Site 50
S208
F
L
G
G
N
L
P
S
D
S
T
S
N
R
S
Site 51
S210
G
G
N
L
P
S
D
S
T
S
N
R
S
V
P
Site 52
T211
G
N
L
P
S
D
S
T
S
N
R
S
V
P
N
Site 53
S212
N
L
P
S
D
S
T
S
N
R
S
V
P
N
R
Site 54
T221
R
S
V
P
N
R
N
T
T
P
C
E
I
F
S
Site 55
T222
S
V
P
N
R
N
T
T
P
C
E
I
F
S
R
Site 56
S228
T
T
P
C
E
I
F
S
R
S
T
S
T
D
P
Site 57
S230
P
C
E
I
F
S
R
S
T
S
T
D
P
F
V
Site 58
T231
C
E
I
F
S
R
S
T
S
T
D
P
F
V
Q
Site 59
S232
E
I
F
S
R
S
T
S
T
D
P
F
V
Q
D
Site 60
S253
E
I
M
K
L
P
V
S
R
N
T
K
I
P
L
Site 61
T256
K
L
P
V
S
R
N
T
K
I
P
L
K
R
Y
Site 62
S264
K
I
P
L
K
R
Y
S
S
L
V
I
F
P
R
Site 63
S272
S
L
V
I
F
P
R
S
P
S
T
T
R
P
T
Site 64
S274
V
I
F
P
R
S
P
S
T
T
R
P
T
S
P
Site 65
T275
I
F
P
R
S
P
S
T
T
R
P
T
S
P
T
Site 66
T276
F
P
R
S
P
S
T
T
R
P
T
S
P
T
S
Site 67
T279
S
P
S
T
T
R
P
T
S
P
T
S
L
C
T
Site 68
S280
P
S
T
T
R
P
T
S
P
T
S
L
C
T
L
Site 69
T282
T
T
R
P
T
S
P
T
S
L
C
T
L
L
S
Site 70
S283
T
R
P
T
S
P
T
S
L
C
T
L
L
S
K
Site 71
T286
T
S
P
T
S
L
C
T
L
L
S
K
G
S
Y
Site 72
S289
T
S
L
C
T
L
L
S
K
G
S
Y
Q
T
S
Site 73
S292
C
T
L
L
S
K
G
S
Y
Q
T
S
H
Q
F
Site 74
Y293
T
L
L
S
K
G
S
Y
Q
T
S
H
Q
F
I
Site 75
S296
S
K
G
S
Y
Q
T
S
H
Q
F
I
I
S
P
Site 76
S302
T
S
H
Q
F
I
I
S
P
S
E
I
A
H
N
Site 77
S304
H
Q
F
I
I
S
P
S
E
I
A
H
N
E
D
Site 78
S314
A
H
N
E
D
G
T
S
A
K
G
F
L
S
T
Site 79
T331
N
G
L
R
L
S
K
T
I
C
T
P
G
E
V
Site 80
T334
R
L
S
K
T
I
C
T
P
G
E
V
R
D
I
Site 81
S349
R
P
L
H
R
K
G
S
L
Q
K
K
I
V
L
Site 82
S357
L
Q
K
K
I
V
L
S
N
N
T
P
R
Q
T
Site 83
T360
K
I
V
L
S
N
N
T
P
R
Q
T
V
C
E
Site 84
T364
S
N
N
T
P
R
Q
T
V
C
E
K
S
S
E
Site 85
S369
R
Q
T
V
C
E
K
S
S
E
G
Y
S
C
V
Site 86
S370
Q
T
V
C
E
K
S
S
E
G
Y
S
C
V
S
Site 87
Y373
C
E
K
S
S
E
G
Y
S
C
V
S
V
H
F
Site 88
S374
E
K
S
S
E
G
Y
S
C
V
S
V
H
F
T
Site 89
S377
S
E
G
Y
S
C
V
S
V
H
F
T
Q
R
K
Site 90
S408
M
S
E
I
K
L
N
S
D
S
E
Y
I
K
L
Site 91
S410
E
I
K
L
N
S
D
S
E
Y
I
K
L
M
H
Site 92
Y412
K
L
N
S
D
S
E
Y
I
K
L
M
H
R
T
Site 93
S420
V
S
Q
P
A
S
S
S
N
H
S
S
R
R
G
Site 94
S426
T
S
A
C
L
P
S
S
Q
N
V
D
C
Q
I
Site 95
S444
G
E
L
E
R
P
H
S
Q
M
N
K
N
H
G
Site 96
S456
N
H
G
I
L
R
R
S
I
S
L
G
G
A
Y
Site 97
S458
G
I
L
R
R
S
I
S
L
G
G
A
Y
P
N
Site 98
S467
G
G
A
Y
P
N
I
S
C
L
S
S
L
K
H
Site 99
S470
Y
P
N
I
S
C
L
S
S
L
K
H
N
C
S
Site 100
S471
P
N
I
S
C
L
S
S
L
K
H
N
C
S
K
Site 101
S477
S
S
L
K
H
N
C
S
K
G
G
P
S
Q
L
Site 102
S490
Q
L
L
I
K
F
A
S
G
N
E
G
K
V
D
Site 103
S500
E
G
K
V
D
N
L
S
R
D
S
N
R
D
C
Site 104
S503
V
D
N
L
S
R
D
S
N
R
D
C
T
N
E
Site 105
T508
R
D
S
N
R
D
C
T
N
E
L
S
N
S
C
Site 106
S512
R
D
C
T
N
E
L
S
N
S
C
K
T
R
D
Site 107
S514
C
T
N
E
L
S
N
S
C
K
T
R
D
D
F
Site 108
Y530
G
Q
V
D
V
P
L
Y
P
L
P
T
E
N
P
Site 109
T534
V
P
L
Y
P
L
P
T
E
N
P
R
L
E
R
Site 110
Y543
N
P
R
L
E
R
P
Y
T
F
K
D
F
V
L
Site 111
T544
P
R
L
E
R
P
Y
T
F
K
D
F
V
L
H
Site 112
S554
D
F
V
L
H
P
R
S
H
K
S
R
V
K
G
Site 113
S557
L
H
P
R
S
H
K
S
R
V
K
G
Y
L
R
Site 114
Y562
H
K
S
R
V
K
G
Y
L
R
L
K
M
T
Y
Site 115
T568
G
Y
L
R
L
K
M
T
Y
L
P
K
T
S
G
Site 116
Y569
Y
L
R
L
K
M
T
Y
L
P
K
T
S
G
S
Site 117
T573
K
M
T
Y
L
P
K
T
S
G
S
E
D
D
N
Site 118
S576
Y
L
P
K
T
S
G
S
E
D
D
N
A
E
Q
Site 119
S610
L
Q
Q
Q
Q
E
P
S
P
L
P
P
G
W
E
Site 120
Y627
Q
D
I
L
G
R
T
Y
Y
V
N
H
E
S
R
Site 121
Y628
D
I
L
G
R
T
Y
Y
V
N
H
E
S
R
R
Site 122
T636
V
N
H
E
S
R
R
T
Q
W
K
R
P
T
P
Site 123
T642
R
T
Q
W
K
R
P
T
P
Q
D
N
L
T
D
Site 124
T648
P
T
P
Q
D
N
L
T
D
A
E
N
G
N
I
Site 125
T664
L
Q
A
Q
R
A
F
T
T
R
R
Q
I
S
E
Site 126
S670
F
T
T
R
R
Q
I
S
E
E
T
E
S
V
D
Site 127
S675
Q
I
S
E
E
T
E
S
V
D
N
Q
E
S
S
Site 128
S681
E
S
V
D
N
Q
E
S
S
E
N
W
E
I
I
Site 129
T694
I
I
R
E
D
E
A
T
M
Y
S
S
Q
A
F
Site 130
Y696
R
E
D
E
A
T
M
Y
S
S
Q
A
F
P
S
Site 131
S697
E
D
E
A
T
M
Y
S
S
Q
A
F
P
S
P
Site 132
S698
D
E
A
T
M
Y
S
S
Q
A
F
P
S
P
P
Site 133
S703
Y
S
S
Q
A
F
P
S
P
P
P
S
S
N
L
Site 134
S707
A
F
P
S
P
P
P
S
S
N
L
D
V
P
T
Site 135
S708
F
P
S
P
P
P
S
S
N
L
D
V
P
T
H
Site 136
S730
R
L
T
I
F
G
N
S
A
V
S
Q
P
A
S
Site 137
S733
I
F
G
N
S
A
V
S
Q
P
A
S
S
S
N
Site 138
S737
S
A
V
S
Q
P
A
S
S
S
N
H
S
S
R
Site 139
S738
A
V
S
Q
P
A
S
S
S
N
H
S
S
R
R
Site 140
S739
V
S
Q
P
A
S
S
S
N
H
S
S
R
R
G
Site 141
S742
P
A
S
S
S
N
H
S
S
R
R
G
S
L
Q
Site 142
S743
A
S
S
S
N
H
S
S
R
R
G
S
L
Q
A
Site 143
S747
N
H
S
S
R
R
G
S
L
Q
A
Y
T
F
E
Site 144
Y751
R
R
G
S
L
Q
A
Y
T
F
E
E
Q
P
T
Site 145
T752
R
G
S
L
Q
A
Y
T
F
E
E
Q
P
T
L
Site 146
T758
Y
T
F
E
E
Q
P
T
L
P
V
L
L
P
T
Site 147
S767
P
V
L
L
P
T
S
S
G
L
P
P
G
W
E
Site 148
S783
K
Q
D
E
R
G
R
S
Y
Y
V
D
H
N
S
Site 149
Y784
Q
D
E
R
G
R
S
Y
Y
V
D
H
N
S
R
Site 150
Y785
D
E
R
G
R
S
Y
Y
V
D
H
N
S
R
T
Site 151
T793
V
D
H
N
S
R
T
T
T
W
T
K
P
T
V
Site 152
T794
D
H
N
S
R
T
T
T
W
T
K
P
T
V
Q
Site 153
T796
N
S
R
T
T
T
W
T
K
P
T
V
Q
A
T
Site 154
T803
T
K
P
T
V
Q
A
T
V
E
T
S
Q
L
T
Site 155
S807
V
Q
A
T
V
E
T
S
Q
L
T
S
S
Q
S
Site 156
T810
T
V
E
T
S
Q
L
T
S
S
Q
S
S
A
G
Site 157
S811
V
E
T
S
Q
L
T
S
S
Q
S
S
A
G
P
Site 158
S812
E
T
S
Q
L
T
S
S
Q
S
S
A
G
P
Q
Site 159
S814
S
Q
L
T
S
S
Q
S
S
A
G
P
Q
S
Q
Site 160
S815
Q
L
T
S
S
Q
S
S
A
G
P
Q
S
Q
A
Site 161
S820
Q
S
S
A
G
P
Q
S
Q
A
S
T
S
D
S
Site 162
S823
A
G
P
Q
S
Q
A
S
T
S
D
S
G
Q
Q
Site 163
T824
G
P
Q
S
Q
A
S
T
S
D
S
G
Q
Q
V
Site 164
S827
S
Q
A
S
T
S
D
S
G
Q
Q
V
T
Q
P
Site 165
T865
F
I
D
H
N
T
K
T
T
T
W
E
D
P
R
Site 166
T883
P
A
H
L
R
G
K
T
S
L
D
T
S
N
D
Site 167
S884
A
H
L
R
G
K
T
S
L
D
T
S
N
D
L
Site 168
T887
R
G
K
T
S
L
D
T
S
N
D
L
G
P
L
Site 169
S888
G
K
T
S
L
D
T
S
N
D
L
G
P
L
P
Site 170
T902
P
P
G
W
E
E
R
T
H
T
D
G
R
I
F
Site 171
T904
G
W
E
E
R
T
H
T
D
G
R
I
F
Y
I
Site 172
Y910
H
T
D
G
R
I
F
Y
I
N
H
N
I
K
R
Site 173
S938
T
G
P
A
V
P
Y
S
R
D
Y
K
R
K
Y
Site 174
Y941
A
V
P
Y
S
R
D
Y
K
R
K
Y
E
F
F
Site 175
Y945
S
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
Site 176
T970
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
Site 177
S975
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
Site 178
Y976
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
Site 179
Y1004
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
Site 180
Y1023
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
Site 181
Y1024
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
Site 182
Y1029
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
Site 183
T1032
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
Site 184
Y1035
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
Site 185
T1036
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
Site 186
Y1053
C
N
E
D
H
L
S
Y
F
K
F
I
G
R
V
Site 187
Y1080
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
Site 188
S1098
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
Site 189
Y1100
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
Site 190
Y1101
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
Site 191
T1113
W
I
L
E
N
D
P
T
E
L
D
L
R
F
I
Site 192
T1144
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
Site 193
Y1153
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
Site 194
T1211
V
N
D
W
R
E
H
T
K
Y
K
N
G
Y
S
Site 195
Y1213
D
W
R
E
H
T
K
Y
K
N
G
Y
S
A
N
Site 196
Y1261
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
Site 197
S1263
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
Site 198
S1268
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
Site 199
T1270
S
N
G
P
Q
S
F
T
V
E
Q
W
G
T
P
Site 200
T1276
F
T
V
E
Q
W
G
T
P
E
K
L
P
R
A
Site 201
T1285
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
Site 202
Y1295
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
Site 203
S1297
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation