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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IQGAP1
Full Name:
Ras GTPase-activating-like protein IQGAP1
Alias:
HUMORFA01; IQ motif containing GTPase activating protein 1; IQG1; IQGA1; KIAA0051; P195; RasGAP-like with IQ motifs; SAR1
Type:
GTPase-activating protein for G protein
Mass (Da):
189252
Number AA:
1657
UniProt ID:
P46940
International Prot ID:
IPI00009342
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005884
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005095
GO:0005099
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007264
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
A
A
D
E
V
D
G
Site 2
Y17
L
G
V
A
R
P
H
Y
G
S
V
L
D
N
E
Site 3
S19
V
A
R
P
H
Y
G
S
V
L
D
N
E
R
L
Site 4
T27
V
L
D
N
E
R
L
T
A
E
E
M
D
E
R
Site 5
Y41
R
R
R
Q
N
V
A
Y
E
Y
L
C
H
L
E
Site 6
Y43
R
Q
N
V
A
Y
E
Y
L
C
H
L
E
E
A
Site 7
T65
L
G
E
D
L
P
P
T
T
E
L
E
E
G
L
Site 8
Y77
E
G
L
R
N
G
V
Y
L
A
K
L
G
N
F
Site 9
Y96
V
V
S
L
K
K
I
Y
D
R
E
Q
T
R
Y
Site 10
T101
K
I
Y
D
R
E
Q
T
R
Y
K
A
T
G
L
Site 11
Y103
Y
D
R
E
Q
T
R
Y
K
A
T
G
L
H
F
Site 12
Y133
I
G
L
P
K
I
F
Y
P
E
T
T
D
I
Y
Site 13
T136
P
K
I
F
Y
P
E
T
T
D
I
Y
D
R
K
Site 14
Y140
Y
P
E
T
T
D
I
Y
D
R
K
N
M
P
R
Site 15
Y172
A
P
Q
I
Q
D
L
Y
G
K
V
D
F
T
E
Site 16
T178
L
Y
G
K
V
D
F
T
E
E
E
I
N
N
M
Site 17
Y192
M
K
T
E
L
E
K
Y
G
I
Q
M
P
A
F
Site 18
T236
D
R
R
I
P
A
D
T
F
A
A
L
K
N
P
Site 19
S256
N
L
E
E
P
L
A
S
T
Y
Q
D
I
L
Y
Site 20
Y263
S
T
Y
Q
D
I
L
Y
Q
A
K
Q
D
K
M
Site 21
S280
A
K
N
R
T
E
N
S
E
R
E
R
D
V
Y
Site 22
Y287
S
E
R
E
R
D
V
Y
E
E
L
L
T
Q
A
Site 23
T292
D
V
Y
E
E
L
L
T
Q
A
E
I
Q
G
N
Site 24
S330
A
L
F
R
A
L
Q
S
P
A
L
G
L
R
G
Site 25
S343
R
G
L
Q
Q
Q
N
S
D
W
Y
L
K
Q
L
Site 26
Y346
Q
Q
Q
N
S
D
W
Y
L
K
Q
L
L
S
D
Site 27
S352
W
Y
L
K
Q
L
L
S
D
K
Q
Q
K
R
Q
Site 28
S360
D
K
Q
Q
K
R
Q
S
G
Q
T
D
P
L
Q
Site 29
S373
L
Q
K
E
E
L
Q
S
G
V
D
A
A
N
S
Site 30
S380
S
G
V
D
A
A
N
S
A
A
Q
Q
Y
Q
R
Site 31
Y385
A
N
S
A
A
Q
Q
Y
Q
R
R
L
A
A
V
Site 32
T407
Q
K
G
V
A
E
K
T
V
L
E
L
M
N
P
Site 33
Y422
E
A
Q
L
P
Q
V
Y
P
F
A
A
D
L
Y
Site 34
Y429
Y
P
F
A
A
D
L
Y
Q
K
E
L
A
T
L
Site 35
T435
L
Y
Q
K
E
L
A
T
L
Q
R
Q
S
P
E
Site 36
S440
L
A
T
L
Q
R
Q
S
P
E
H
N
L
T
H
Site 37
T446
Q
S
P
E
H
N
L
T
H
P
E
L
S
V
A
Site 38
T474
L
E
S
G
D
V
N
T
V
W
K
Q
L
S
S
Site 39
S480
N
T
V
W
K
Q
L
S
S
S
V
T
G
L
T
Site 40
T484
K
Q
L
S
S
S
V
T
G
L
T
N
I
E
E
Site 41
Y497
E
E
E
N
C
Q
R
Y
L
D
E
L
M
K
L
Site 42
T557
D
E
G
D
A
Q
K
T
L
Q
A
L
Q
I
P
Site 43
T582
V
A
Q
H
Y
Q
D
T
L
I
R
A
K
R
E
Site 44
T617
I
W
Q
S
N
K
D
T
Q
E
A
Q
K
F
A
Site 45
S636
A
I
N
E
A
V
E
S
G
D
V
G
K
T
L
Site 46
T642
E
S
G
D
V
G
K
T
L
S
A
L
R
S
P
Site 47
S644
G
D
V
G
K
T
L
S
A
L
R
S
P
D
V
Site 48
S648
K
T
L
S
A
L
R
S
P
D
V
G
L
Y
G
Site 49
Y654
R
S
P
D
V
G
L
Y
G
V
I
P
E
C
G
Site 50
T663
V
I
P
E
C
G
E
T
Y
H
S
D
L
A
E
Site 51
S666
E
C
G
E
T
Y
H
S
D
L
A
E
A
K
K
Site 52
Y694
K
H
W
V
K
G
G
Y
Y
Y
Y
H
N
L
E
Site 53
Y695
H
W
V
K
G
G
Y
Y
Y
Y
H
N
L
E
T
Site 54
Y696
W
V
K
G
G
Y
Y
Y
Y
H
N
L
E
T
Q
Site 55
Y697
V
K
G
G
Y
Y
Y
Y
H
N
L
E
T
Q
E
Site 56
S717
P
P
N
F
V
Q
N
S
M
Q
L
S
R
E
E
Site 57
S721
V
Q
N
S
M
Q
L
S
R
E
E
I
Q
S
S
Site 58
S727
L
S
R
E
E
I
Q
S
S
I
S
G
V
T
A
Site 59
S728
S
R
E
E
I
Q
S
S
I
S
G
V
T
A
A
Site 60
S730
E
E
I
Q
S
S
I
S
G
V
T
A
A
Y
N
Site 61
Y736
I
S
G
V
T
A
A
Y
N
R
E
Q
L
W
L
Site 62
Y759
L
Q
A
R
C
R
G
Y
L
V
R
Q
E
F
R
Site 63
S767
L
V
R
Q
E
F
R
S
R
M
N
F
L
K
K
Site 64
Y789
I
Q
S
Q
W
R
G
Y
K
Q
K
K
A
Y
Q
Site 65
Y801
A
Y
Q
D
R
L
A
Y
L
R
S
H
K
D
E
Site 66
S804
D
R
L
A
Y
L
R
S
H
K
D
E
V
V
K
Site 67
S814
D
E
V
V
K
I
Q
S
L
A
R
M
H
Q
A
Site 68
Y825
M
H
Q
A
R
K
R
Y
R
D
R
L
Q
Y
F
Site 69
Y831
R
Y
R
D
R
L
Q
Y
F
R
D
H
I
N
D
Site 70
Y855
A
N
K
A
R
D
D
Y
K
T
L
I
N
A
E
Site 71
T857
K
A
R
D
D
Y
K
T
L
I
N
A
E
D
P
Site 72
S879
F
V
H
L
L
D
Q
S
D
Q
D
F
Q
E
E
Site 73
T898
K
M
R
E
E
V
I
T
L
I
R
S
N
Q
Q
Site 74
S932
I
T
L
Q
D
V
V
S
H
S
K
K
L
T
K
Site 75
T938
V
S
H
S
K
K
L
T
K
K
N
K
E
Q
L
Site 76
S962
K
G
G
L
K
A
L
S
K
E
K
R
E
K
L
Site 77
Y972
K
R
E
K
L
E
A
Y
Q
H
L
F
Y
L
L
Site 78
Y977
E
A
Y
Q
H
L
F
Y
L
L
Q
T
N
P
T
Site 79
S1004
K
S
T
K
F
M
D
S
V
I
F
T
L
Y
N
Site 80
Y1010
D
S
V
I
F
T
L
Y
N
Y
A
S
N
Q
R
Site 81
Y1020
A
S
N
Q
R
E
E
Y
L
L
L
R
L
F
K
Site 82
S1036
A
L
Q
E
E
I
K
S
K
V
D
Q
I
Q
E
Site 83
T1046
D
Q
I
Q
E
I
V
T
G
N
P
T
V
I
K
Site 84
S1084
K
E
I
M
D
D
K
S
L
N
I
K
T
D
P
Site 85
T1089
D
K
S
L
N
I
K
T
D
P
V
D
I
Y
K
Site 86
Y1095
K
T
D
P
V
D
I
Y
K
S
W
V
N
Q
M
Site 87
S1104
S
W
V
N
Q
M
E
S
Q
T
G
E
A
S
K
Site 88
Y1114
G
E
A
S
K
L
P
Y
D
V
T
P
E
Q
A
Site 89
T1117
S
K
L
P
Y
D
V
T
P
E
Q
A
L
A
H
Site 90
T1129
L
A
H
E
E
V
K
T
R
L
D
S
S
I
R
Site 91
S1133
E
V
K
T
R
L
D
S
S
I
R
N
M
R
A
Site 92
S1134
V
K
T
R
L
D
S
S
I
R
N
M
R
A
V
Site 93
S1147
A
V
T
D
K
F
L
S
A
I
V
S
S
V
D
Site 94
S1151
K
F
L
S
A
I
V
S
S
V
D
K
I
P
Y
Site 95
S1152
F
L
S
A
I
V
S
S
V
D
K
I
P
Y
G
Site 96
Y1158
S
S
V
D
K
I
P
Y
G
M
R
F
I
A
K
Site 97
S1170
I
A
K
V
L
K
D
S
L
H
E
K
F
P
D
Site 98
Y1192
K
I
I
G
N
L
L
Y
Y
R
Y
M
N
P
A
Site 99
S1227
D
Q
R
R
N
L
G
S
I
A
K
M
L
Q
H
Site 100
S1237
K
M
L
Q
H
A
A
S
N
K
M
F
L
G
D
Site 101
S1249
L
G
D
N
A
H
L
S
I
I
N
E
Y
L
S
Site 102
Y1254
H
L
S
I
I
N
E
Y
L
S
Q
S
Y
Q
K
Site 103
S1256
S
I
I
N
E
Y
L
S
Q
S
Y
Q
K
F
R
Site 104
T1268
K
F
R
R
F
F
Q
T
A
C
D
V
P
E
L
Site 105
Y1284
D
K
F
N
V
D
E
Y
S
D
L
V
T
L
T
Site 106
S1285
K
F
N
V
D
E
Y
S
D
L
V
T
L
T
K
Site 107
T1289
D
E
Y
S
D
L
V
T
L
T
K
P
V
I
Y
Site 108
S1339
G
E
V
P
T
I
E
S
L
I
G
E
S
S
G
Site 109
S1345
E
S
L
I
G
E
S
S
G
N
L
N
D
P
N
Site 110
T1359
N
K
E
A
L
A
K
T
E
V
S
L
T
L
T
Site 111
T1364
A
K
T
E
V
S
L
T
L
T
N
K
F
D
V
Site 112
T1366
T
E
V
S
L
T
L
T
N
K
F
D
V
P
G
Site 113
T1410
T
L
T
E
I
L
E
T
P
A
T
S
E
Q
E
Site 114
T1413
E
I
L
E
T
P
A
T
S
E
Q
E
A
E
H
Site 115
T1434
R
A
I
R
D
A
K
T
P
D
K
M
K
K
S
Site 116
S1441
T
P
D
K
M
K
K
S
K
S
V
K
E
D
S
Site 117
S1443
D
K
M
K
K
S
K
S
V
K
E
D
S
N
L
Site 118
S1448
S
K
S
V
K
E
D
S
N
L
T
L
Q
E
K
Site 119
T1451
V
K
E
D
S
N
L
T
L
Q
E
K
K
E
K
Site 120
T1461
E
K
K
E
K
I
Q
T
G
L
K
K
L
T
E
Site 121
T1467
Q
T
G
L
K
K
L
T
E
L
G
T
V
D
P
Site 122
T1471
K
K
L
T
E
L
G
T
V
D
P
K
N
K
Y
Site 123
Y1478
T
V
D
P
K
N
K
Y
Q
E
L
I
N
D
I
Site 124
Y1495
D
I
R
N
Q
R
R
Y
R
Q
R
R
K
A
E
Site 125
T1509
E
L
V
K
L
Q
Q
T
Y
A
A
L
N
S
K
Site 126
Y1510
L
V
K
L
Q
Q
T
Y
A
A
L
N
S
K
A
Site 127
T1518
A
A
L
N
S
K
A
T
F
Y
G
E
Q
V
D
Site 128
Y1526
F
Y
G
E
Q
V
D
Y
Y
K
S
Y
I
K
T
Site 129
Y1527
Y
G
E
Q
V
D
Y
Y
K
S
Y
I
K
T
C
Site 130
T1533
Y
Y
K
S
Y
I
K
T
C
L
D
N
L
A
S
Site 131
S1540
T
C
L
D
N
L
A
S
K
G
K
V
S
K
K
Site 132
S1556
R
E
M
K
G
K
K
S
K
K
I
S
L
K
Y
Site 133
S1560
G
K
K
S
K
K
I
S
L
K
Y
T
A
A
R
Site 134
Y1563
S
K
K
I
S
L
K
Y
T
A
A
R
L
H
E
Site 135
T1564
K
K
I
S
L
K
Y
T
A
A
R
L
H
E
K
Site 136
S1593
K
N
V
I
F
E
I
S
P
T
E
E
V
G
D
Site 137
Y1627
Q
D
L
L
Q
L
Q
Y
E
G
V
A
V
M
K
Site 138
Y1655
F
L
L
N
K
K
F
Y
G
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation