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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rap1GAP
Full Name:
Rap1 GTPase-activating protein 1
Alias:
KIAA0474; RAP1 GTPase activating protein; RAP1GA1; RAP1GAP1; RAP1GAPII; RGP2; RPGP1
Type:
GTPase-activating protein for G protein
Mass (Da):
73361
Number AA:
663
UniProt ID:
P47736
International Prot ID:
IPI00514917
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
R
M
D
E
Q
R
C
S
F
P
P
P
L
K
T
Site 2
T23
S
F
P
P
P
L
K
T
E
E
D
Y
I
P
Y
Site 3
Y27
P
L
K
T
E
E
D
Y
I
P
Y
P
S
V
H
Site 4
Y30
T
E
E
D
Y
I
P
Y
P
S
V
H
E
V
L
Site 5
S32
E
D
Y
I
P
Y
P
S
V
H
E
V
L
G
R
Site 6
Y54
L
L
P
Q
F
G
G
Y
W
I
E
G
T
N
H
Site 7
T64
E
G
T
N
H
E
I
T
S
I
P
E
T
E
P
Site 8
S65
G
T
N
H
E
I
T
S
I
P
E
T
E
P
L
Site 9
T69
E
I
T
S
I
P
E
T
E
P
L
Q
S
P
T
Site 10
S74
P
E
T
E
P
L
Q
S
P
T
T
K
V
K
L
Site 11
T77
E
P
L
Q
S
P
T
T
K
V
K
L
E
C
N
Site 12
T86
V
K
L
E
C
N
P
T
A
R
I
Y
R
K
H
Site 13
Y90
C
N
P
T
A
R
I
Y
R
K
H
F
L
G
K
Site 14
Y102
L
G
K
E
H
F
N
Y
Y
S
L
D
A
A
L
Site 15
S104
K
E
H
F
N
Y
Y
S
L
D
A
A
L
G
H
Site 16
Y118
H
L
V
F
S
L
K
Y
D
V
I
G
D
Q
E
Site 17
T133
H
L
R
L
L
L
R
T
K
C
R
T
Y
H
D
Site 18
T137
L
L
R
T
K
C
R
T
Y
H
D
V
I
P
I
Site 19
Y138
L
R
T
K
C
R
T
Y
H
D
V
I
P
I
S
Site 20
Y170
D
V
N
V
D
R
F
Y
P
V
L
Y
P
K
A
Site 21
Y174
D
R
F
Y
P
V
L
Y
P
K
A
S
R
L
I
Site 22
Y199
N
F
K
F
G
V
I
Y
Q
K
L
G
Q
T
S
Site 23
S212
T
S
E
E
E
L
F
S
T
N
E
E
S
P
A
Site 24
T213
S
E
E
E
L
F
S
T
N
E
E
S
P
A
F
Site 25
T246
F
R
G
G
L
D
V
T
H
G
Q
T
G
T
E
Site 26
Y256
Q
T
G
T
E
S
V
Y
C
N
F
R
N
K
E
Site 27
Y332
G
G
P
D
G
P
L
Y
K
V
S
V
T
A
R
Site 28
S335
D
G
P
L
Y
K
V
S
V
T
A
R
D
D
V
Site 29
T367
E
F
Q
E
F
L
L
T
K
L
I
N
A
E
Y
Site 30
Y374
T
K
L
I
N
A
E
Y
A
C
Y
K
A
E
K
Site 31
Y377
I
N
A
E
Y
A
C
Y
K
A
E
K
F
A
K
Site 32
S405
Y
E
E
L
H
I
H
S
Q
S
M
M
G
L
G
Site 33
S407
E
L
H
I
H
S
Q
S
M
M
G
L
G
G
D
Site 34
S430
G
G
G
G
F
F
E
S
F
K
R
V
I
R
S
Site 35
S437
S
F
K
R
V
I
R
S
R
S
Q
S
M
D
A
Site 36
S439
K
R
V
I
R
S
R
S
Q
S
M
D
A
M
G
Site 37
S441
V
I
R
S
R
S
Q
S
M
D
A
M
G
L
S
Site 38
S448
S
M
D
A
M
G
L
S
N
K
K
P
N
T
V
Site 39
T454
L
S
N
K
K
P
N
T
V
S
T
S
H
S
G
Site 40
S456
N
K
K
P
N
T
V
S
T
S
H
S
G
S
F
Site 41
S458
K
P
N
T
V
S
T
S
H
S
G
S
F
A
P
Site 42
S460
N
T
V
S
T
S
H
S
G
S
F
A
P
N
N
Site 43
S462
V
S
T
S
H
S
G
S
F
A
P
N
N
P
D
Site 44
S484
S
L
I
V
P
G
K
S
P
T
R
K
K
S
G
Site 45
T486
I
V
P
G
K
S
P
T
R
K
K
S
G
P
F
Site 46
S490
K
S
P
T
R
K
K
S
G
P
F
G
S
R
R
Site 47
S495
K
K
S
G
P
F
G
S
R
R
S
S
A
I
G
Site 48
S498
G
P
F
G
S
R
R
S
S
A
I
G
I
E
N
Site 49
S499
P
F
G
S
R
R
S
S
A
I
G
I
E
N
I
Site 50
S515
E
V
Q
E
K
R
E
S
P
P
A
G
Q
K
T
Site 51
T522
S
P
P
A
G
Q
K
T
P
D
S
G
H
V
S
Site 52
S525
A
G
Q
K
T
P
D
S
G
H
V
S
Q
E
P
Site 53
S529
T
P
D
S
G
H
V
S
Q
E
P
K
S
E
N
Site 54
S534
H
V
S
Q
E
P
K
S
E
N
S
S
T
Q
S
Site 55
S537
Q
E
P
K
S
E
N
S
S
T
Q
S
S
P
E
Site 56
S538
E
P
K
S
E
N
S
S
T
Q
S
S
P
E
M
Site 57
T539
P
K
S
E
N
S
S
T
Q
S
S
P
E
M
P
Site 58
S541
S
E
N
S
S
T
Q
S
S
P
E
M
P
T
T
Site 59
S542
E
N
S
S
T
Q
S
S
P
E
M
P
T
T
K
Site 60
T547
Q
S
S
P
E
M
P
T
T
K
N
R
A
E
T
Site 61
T548
S
S
P
E
M
P
T
T
K
N
R
A
E
T
A
Site 62
T554
T
T
K
N
R
A
E
T
A
A
Q
R
A
E
A
Site 63
S566
A
E
A
L
K
D
F
S
R
S
S
S
S
A
S
Site 64
S568
A
L
K
D
F
S
R
S
S
S
S
A
S
S
F
Site 65
S569
L
K
D
F
S
R
S
S
S
S
A
S
S
F
A
Site 66
S570
K
D
F
S
R
S
S
S
S
A
S
S
F
A
S
Site 67
S571
D
F
S
R
S
S
S
S
A
S
S
F
A
S
V
Site 68
S573
S
R
S
S
S
S
A
S
S
F
A
S
V
V
E
Site 69
S574
R
S
S
S
S
A
S
S
F
A
S
V
V
E
E
Site 70
S577
S
S
A
S
S
F
A
S
V
V
E
E
T
E
G
Site 71
T590
E
G
V
D
G
E
D
T
G
L
E
S
V
S
S
Site 72
S594
G
E
D
T
G
L
E
S
V
S
S
S
G
T
P
Site 73
S596
D
T
G
L
E
S
V
S
S
S
G
T
P
H
K
Site 74
S597
T
G
L
E
S
V
S
S
S
G
T
P
H
K
R
Site 75
S598
G
L
E
S
V
S
S
S
G
T
P
H
K
R
D
Site 76
T600
E
S
V
S
S
S
G
T
P
H
K
R
D
S
F
Site 77
S606
G
T
P
H
K
R
D
S
F
I
Y
S
T
W
L
Site 78
Y609
H
K
R
D
S
F
I
Y
S
T
W
L
E
D
S
Site 79
S610
K
R
D
S
F
I
Y
S
T
W
L
E
D
S
V
Site 80
S616
Y
S
T
W
L
E
D
S
V
S
T
T
S
G
G
Site 81
S618
T
W
L
E
D
S
V
S
T
T
S
G
G
S
S
Site 82
T620
L
E
D
S
V
S
T
T
S
G
G
S
S
P
G
Site 83
S621
E
D
S
V
S
T
T
S
G
G
S
S
P
G
P
Site 84
S625
S
T
T
S
G
G
S
S
P
G
P
S
R
S
P
Site 85
S629
G
G
S
S
P
G
P
S
R
S
P
H
P
D
A
Site 86
S631
S
S
P
G
P
S
R
S
P
H
P
D
A
G
K
Site 87
S654
I
K
I
Q
L
E
A
S
E
Q
H
M
P
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation