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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALDH1A3
Full Name:
Aldehyde dehydrogenase family 1 member A3
Alias:
AL1A3; Aldehyde dehydrogenase 1 family, member A3; Aldehyde dehydrogenase 1, A3; Aldehyde dehydrogenase 1A3; Aldehyde dehydrogenase 6; ALDH1A6; ALDH6; EC 1.2.1.5; RALDH3; RALDH-3; Retinaldehyde dehydrogenase 3
Type:
Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; EC 1.2.1.5
Mass (Da):
56108
Number AA:
512
UniProt ID:
P47895
International Prot ID:
IPI00026663
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004028
GO:0004030
PhosphoSite+
KinaseNET
Biological Process:
GO:0006066
GO:0006629
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
R
N
L
E
V
K
F
T
K
I
F
I
N
N
E
Site 2
T51
K
S
G
K
K
F
A
T
C
N
P
S
T
R
E
Site 3
S86
Q
V
A
F
Q
R
G
S
P
W
R
R
L
D
A
Site 4
S95
W
R
R
L
D
A
L
S
R
G
R
L
L
H
Q
Site 5
T122
A
A
L
E
T
M
D
T
G
K
P
F
L
H
A
Site 6
T140
D
L
E
G
C
I
R
T
L
R
Y
F
A
G
W
Site 7
Y143
G
C
I
R
T
L
R
Y
F
A
G
W
A
D
K
Site 8
S245
P
T
V
G
A
A
I
S
S
H
P
Q
I
N
K
Site 9
T278
R
S
N
L
K
R
V
T
L
E
L
G
G
K
N
Site 10
Y327
V
F
V
E
E
Q
V
Y
S
E
F
V
R
R
S
Site 11
S328
F
V
E
E
Q
V
Y
S
E
F
V
R
R
S
V
Site 12
S334
Y
S
E
F
V
R
R
S
V
E
Y
A
K
K
R
Site 13
Y337
F
V
R
R
S
V
E
Y
A
K
K
R
P
V
G
Site 14
T351
G
D
P
F
D
V
K
T
E
Q
G
P
Q
I
D
Site 15
S371
K
I
L
E
L
I
E
S
G
K
K
E
G
A
K
Site 16
S384
A
K
L
E
C
G
G
S
A
M
E
D
K
G
L
Site 17
S424
Q
P
I
L
K
F
K
S
I
E
E
V
I
K
R
Site 18
S434
E
V
I
K
R
A
N
S
T
D
Y
G
L
T
A
Site 19
Y437
K
R
A
N
S
T
D
Y
G
L
T
A
A
V
F
Site 20
T440
N
S
T
D
Y
G
L
T
A
A
V
F
T
K
N
Site 21
S483
P
F
G
G
F
K
M
S
G
N
G
R
E
L
G
Site 22
Y492
N
G
R
E
L
G
E
Y
A
L
A
E
Y
T
E
Site 23
Y497
G
E
Y
A
L
A
E
Y
T
E
V
K
T
V
T
Site 24
T502
A
E
Y
T
E
V
K
T
V
T
I
K
L
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation