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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNJ6
Full Name:
G protein-activated inward rectifier potassium channel 2
Alias:
BIR1; GIRK2; HiGIRK2; Inward rectifier K(+) channel Kir3.2; IRK6; KATP2; KATP-2; KCNJ7; KIR3.2; Potassium channel, inwardly rectifying subfamily J member 6; Potassium inwardly-rectifying channel, subfamily J, member 6
Type:
Voltage-gated potassium channel complex, Plasma membrane, Golgi apparatus, Integral to membrane protein
Mass (Da):
48451
Number AA:
423
UniProt ID:
P48051
International Prot ID:
IPI00007627
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0015467
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
K
L
T
E
S
M
T
N
V
L
E
G
Site 2
T9
A
K
L
T
E
S
M
T
N
V
L
E
G
D
S
Site 3
S23
S
M
D
Q
D
V
E
S
P
V
A
I
H
Q
P
Site 4
S45
D
D
L
P
R
H
I
S
R
D
R
T
K
R
K
Site 5
T49
R
H
I
S
R
D
R
T
K
R
K
I
Q
R
Y
Site 6
Y56
T
K
R
K
I
Q
R
Y
V
R
K
D
G
K
C
Site 7
Y74
H
G
N
V
R
E
T
Y
R
Y
L
T
D
I
F
Site 8
Y76
N
V
R
E
T
Y
R
Y
L
T
D
I
F
T
T
Site 9
T78
R
E
T
Y
R
Y
L
T
D
I
F
T
T
L
V
Site 10
T130
H
I
E
D
P
S
W
T
P
C
V
T
N
L
N
Site 11
T152
F
S
I
E
T
E
T
T
I
G
Y
G
Y
R
V
Site 12
T161
G
Y
G
Y
R
V
I
T
D
K
C
P
E
G
I
Site 13
S194
G
C
M
F
V
K
I
S
Q
P
K
K
R
A
E
Site 14
T202
Q
P
K
K
R
A
E
T
L
V
F
S
T
H
A
Site 15
S212
F
S
T
H
A
V
I
S
M
R
D
G
K
L
C
Site 16
S230
R
V
G
D
L
R
N
S
H
I
V
E
A
S
I
Site 17
S236
N
S
H
I
V
E
A
S
I
R
A
K
L
I
K
Site 18
S244
I
R
A
K
L
I
K
S
K
Q
T
S
E
G
E
Site 19
S248
L
I
K
S
K
Q
T
S
E
G
E
F
I
P
L
Site 20
S287
S
H
E
I
N
Q
Q
S
P
F
W
E
I
S
K
Site 21
S293
Q
S
P
F
W
E
I
S
K
A
Q
L
P
K
E
Site 22
S323
G
M
T
C
Q
A
R
S
S
Y
I
T
S
E
I
Site 23
S324
M
T
C
Q
A
R
S
S
Y
I
T
S
E
I
L
Site 24
Y325
T
C
Q
A
R
S
S
Y
I
T
S
E
I
L
W
Site 25
T327
Q
A
R
S
S
Y
I
T
S
E
I
L
W
G
Y
Site 26
S328
A
R
S
S
Y
I
T
S
E
I
L
W
G
Y
R
Site 27
T341
Y
R
F
T
P
V
L
T
L
E
D
G
F
Y
E
Site 28
Y347
L
T
L
E
D
G
F
Y
E
V
D
Y
N
S
F
Site 29
Y351
D
G
F
Y
E
V
D
Y
N
S
F
H
E
T
Y
Site 30
T357
D
Y
N
S
F
H
E
T
Y
E
T
S
T
P
S
Site 31
Y358
Y
N
S
F
H
E
T
Y
E
T
S
T
P
S
L
Site 32
T360
S
F
H
E
T
Y
E
T
S
T
P
S
L
S
A
Site 33
T362
H
E
T
Y
E
T
S
T
P
S
L
S
A
K
E
Site 34
S364
T
Y
E
T
S
T
P
S
L
S
A
K
E
L
A
Site 35
S366
E
T
S
T
P
S
L
S
A
K
E
L
A
E
L
Site 36
S375
K
E
L
A
E
L
A
S
R
A
E
L
P
L
S
Site 37
S382
S
R
A
E
L
P
L
S
W
S
V
S
S
K
L
Site 38
S384
A
E
L
P
L
S
W
S
V
S
S
K
L
N
Q
Site 39
S386
L
P
L
S
W
S
V
S
S
K
L
N
Q
H
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation