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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PREP
Full Name:
Prolyl endopeptidase
Alias:
Post-proline cleaving enzyme; PPCE
Type:
Protease; EC 3.4.21.26
Mass (Da):
80700
Number AA:
710
UniProt ID:
P48147
International Prot ID:
IPI00008164
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
S
L
Q
Y
P
D
V
Y
R
D
E
T
A
V
Q
Site 2
T14
P
D
V
Y
R
D
E
T
A
V
Q
D
Y
H
G
Site 3
Y19
D
E
T
A
V
Q
D
Y
H
G
H
K
I
C
D
Site 4
Y28
G
H
K
I
C
D
P
Y
A
W
L
E
D
P
D
Site 5
S36
A
W
L
E
D
P
D
S
E
Q
T
K
A
F
V
Site 6
T50
V
E
A
Q
N
K
I
T
V
P
F
L
E
Q
C
Site 7
Y63
Q
C
P
I
R
G
L
Y
K
E
R
M
T
E
L
Site 8
T68
G
L
Y
K
E
R
M
T
E
L
Y
D
Y
P
K
Site 9
Y71
K
E
R
M
T
E
L
Y
D
Y
P
K
Y
S
C
Site 10
Y73
R
M
T
E
L
Y
D
Y
P
K
Y
S
C
H
F
Site 11
Y76
E
L
Y
D
Y
P
K
Y
S
C
H
F
K
K
G
Site 12
Y86
H
F
K
K
G
K
R
Y
F
Y
F
Y
N
T
G
Site 13
Y88
K
K
G
K
R
Y
F
Y
F
Y
N
T
G
L
Q
Site 14
Y90
G
K
R
Y
F
Y
F
Y
N
T
G
L
Q
N
Q
Site 15
Y101
L
Q
N
Q
R
V
L
Y
V
Q
D
S
L
E
G
Site 16
S105
R
V
L
Y
V
Q
D
S
L
E
G
E
A
R
V
Site 17
T124
N
I
L
S
D
D
G
T
V
A
L
R
G
Y
A
Site 18
Y130
G
T
V
A
L
R
G
Y
A
F
S
E
D
G
E
Site 19
S133
A
L
R
G
Y
A
F
S
E
D
G
E
Y
F
A
Site 20
Y138
A
F
S
E
D
G
E
Y
F
A
Y
G
L
S
A
Site 21
Y141
E
D
G
E
Y
F
A
Y
G
L
S
A
S
G
S
Site 22
S144
E
Y
F
A
Y
G
L
S
A
S
G
S
D
W
V
Site 23
T152
A
S
G
S
D
W
V
T
I
K
F
M
K
V
D
Site 24
Y187
H
D
G
K
G
M
F
Y
N
S
Y
P
Q
Q
D
Site 25
Y190
K
G
M
F
Y
N
S
Y
P
Q
Q
D
G
K
S
Site 26
S197
Y
P
Q
Q
D
G
K
S
D
G
T
E
T
S
T
Site 27
T200
Q
D
G
K
S
D
G
T
E
T
S
T
N
L
H
Site 28
Y211
T
N
L
H
Q
K
L
Y
Y
H
V
L
G
T
D
Site 29
Y212
N
L
H
Q
K
L
Y
Y
H
V
L
G
T
D
Q
Site 30
S220
H
V
L
G
T
D
Q
S
E
D
I
L
C
A
E
Site 31
S241
W
M
G
G
A
E
L
S
D
D
G
R
Y
V
L
Site 32
Y246
E
L
S
D
D
G
R
Y
V
L
L
S
I
R
E
Site 33
S250
D
G
R
Y
V
L
L
S
I
R
E
G
C
D
P
Site 34
Y263
D
P
V
N
R
L
W
Y
C
D
L
Q
Q
E
S
Site 35
Y290
I
D
N
F
E
G
E
Y
D
Y
V
T
N
E
G
Site 36
Y292
N
F
E
G
E
Y
D
Y
V
T
N
E
G
T
V
Site 37
T294
E
G
E
Y
D
Y
V
T
N
E
G
T
V
F
T
Site 38
T304
G
T
V
F
T
F
K
T
N
R
Q
S
P
N
Y
Site 39
S308
T
F
K
T
N
R
Q
S
P
N
Y
R
V
I
N
Site 40
Y311
T
N
R
Q
S
P
N
Y
R
V
I
N
I
D
F
Site 41
S324
D
F
R
D
P
E
E
S
K
W
K
V
L
V
P
Site 42
Y396
K
K
D
T
E
I
F
Y
Q
F
T
S
F
L
S
Site 43
T413
I
I
Y
H
C
D
L
T
K
E
E
L
E
P
R
Site 44
T426
P
R
V
F
R
E
V
T
V
K
G
I
D
A
S
Site 45
S433
T
V
K
G
I
D
A
S
D
Y
Q
T
V
Q
I
Site 46
Y435
K
G
I
D
A
S
D
Y
Q
T
V
Q
I
F
Y
Site 47
T437
I
D
A
S
D
Y
Q
T
V
Q
I
F
Y
P
S
Site 48
Y442
Y
Q
T
V
Q
I
F
Y
P
S
K
D
G
T
K
Site 49
S465
K
G
I
K
L
D
G
S
H
P
A
F
L
Y
G
Site 50
S479
G
Y
G
G
F
N
I
S
I
T
P
N
Y
S
V
Site 51
T481
G
G
F
N
I
S
I
T
P
N
Y
S
V
S
R
Site 52
Y510
N
I
R
G
G
G
E
Y
G
E
T
W
H
K
G
Site 53
T513
G
G
G
E
Y
G
E
T
W
H
K
G
G
I
L
Site 54
Y536
D
F
Q
C
A
A
E
Y
L
I
K
E
G
Y
T
Site 55
Y542
E
Y
L
I
K
E
G
Y
T
S
P
K
R
L
T
Site 56
S544
L
I
K
E
G
Y
T
S
P
K
R
L
T
I
N
Site 57
T549
Y
T
S
P
K
R
L
T
I
N
G
G
S
N
G
Site 58
T596
Y
T
I
G
H
A
W
T
T
D
Y
G
C
S
D
Site 59
Y599
G
H
A
W
T
T
D
Y
G
C
S
D
S
K
Q
Site 60
Y614
H
F
E
W
L
V
K
Y
S
P
L
H
N
V
K
Site 61
S615
F
E
W
L
V
K
Y
S
P
L
H
N
V
K
L
Site 62
Y630
P
E
A
D
D
I
Q
Y
P
S
M
L
L
L
T
Site 63
Y658
K
F
I
A
T
L
Q
Y
I
V
G
R
S
R
K
Site 64
S667
V
G
R
S
R
K
Q
S
N
P
L
L
I
H
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation