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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IREB2
Full Name:
Iron-responsive element-binding protein 2
Alias:
ACO3; IRE-BP 2; Iron regulatory 2; Iron-responsive element-binding 2; IRP2; IRP2AD
Type:
mRNA regulatory binding protein; Cytoplasm
Mass (Da):
105012
Number AA:
963
UniProt ID:
P48200
International Prot ID:
IPI00008726
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0005506
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
K
A
G
Y
A
F
E
Y
L
I
E
T
L
N
D
Site 2
T16
A
F
E
Y
L
I
E
T
L
N
D
S
S
H
K
Site 3
S20
L
I
E
T
L
N
D
S
S
H
K
K
F
F
D
Site 4
S29
H
K
K
F
F
D
V
S
K
L
G
T
K
Y
D
Site 5
T33
F
D
V
S
K
L
G
T
K
Y
D
V
L
P
Y
Site 6
Y40
T
K
Y
D
V
L
P
Y
S
I
R
V
L
L
E
Site 7
T108
A
M
R
E
A
V
K
T
L
G
G
D
P
E
K
Site 8
S129
T
D
L
T
V
D
H
S
L
Q
I
D
F
S
K
Site 9
S157
L
Q
K
A
G
K
L
S
P
L
K
V
Q
P
K
Site 10
T172
K
L
P
C
R
G
Q
T
T
C
R
G
S
C
D
Site 11
T173
L
P
C
R
G
Q
T
T
C
R
G
S
C
D
S
Site 12
S177
G
Q
T
T
C
R
G
S
C
D
S
G
E
L
G
Site 13
S180
T
C
R
G
S
C
D
S
G
E
L
G
R
N
S
Site 14
S187
S
G
E
L
G
R
N
S
G
T
F
S
S
Q
I
Site 15
T189
E
L
G
R
N
S
G
T
F
S
S
Q
I
E
N
Site 16
S191
G
R
N
S
G
T
F
S
S
Q
I
E
N
T
P
Site 17
S192
R
N
S
G
T
F
S
S
Q
I
E
N
T
P
I
Site 18
T197
F
S
S
Q
I
E
N
T
P
I
L
C
P
F
H
Site 19
T213
Q
P
V
P
E
P
E
T
V
L
K
N
Q
E
V
Site 20
Y259
A
H
Q
I
N
L
E
Y
L
S
R
V
V
F
E
Site 21
S275
K
D
L
L
F
P
D
S
V
V
G
T
D
S
H
Site 22
S281
D
S
V
V
G
T
D
S
H
I
T
M
V
N
G
Site 23
T391
F
F
P
V
D
N
V
T
L
K
H
L
E
H
T
Site 24
T410
A
K
L
E
S
M
E
T
Y
L
K
A
V
K
L
Site 25
Y411
K
L
E
S
M
E
T
Y
L
K
A
V
K
L
F
Site 26
S424
L
F
R
N
D
Q
N
S
S
G
E
P
E
Y
S
Site 27
Y430
N
S
S
G
E
P
E
Y
S
Q
V
I
Q
I
N
Site 28
S431
S
S
G
E
P
E
Y
S
Q
V
I
Q
I
N
L
Site 29
S444
N
L
N
S
I
V
P
S
V
S
G
P
K
R
P
Site 30
S446
N
S
I
V
P
S
V
S
G
P
K
R
P
Q
D
Site 31
T458
P
Q
D
R
V
A
V
T
D
M
K
S
D
F
Q
Site 32
S489
E
K
Q
K
D
I
V
S
I
H
Y
E
G
S
E
Site 33
S495
V
S
I
H
Y
E
G
S
E
Y
K
L
S
H
G
Site 34
Y497
I
H
Y
E
G
S
E
Y
K
L
S
H
G
S
V
Site 35
S500
E
G
S
E
Y
K
L
S
H
G
S
V
V
I
A
Site 36
Y541
A
G
L
R
V
K
P
Y
I
R
T
S
L
S
P
Site 37
S545
V
K
P
Y
I
R
T
S
L
S
P
G
S
G
M
Site 38
S547
P
Y
I
R
T
S
L
S
P
G
S
G
M
V
T
Site 39
S550
R
T
S
L
S
P
G
S
G
M
V
T
H
Y
L
Site 40
T554
S
P
G
S
G
M
V
T
H
Y
L
S
S
S
G
Site 41
T647
T
V
N
I
D
F
Q
T
E
P
L
G
T
D
P
Site 42
T652
F
Q
T
E
P
L
G
T
D
P
T
G
K
N
I
Site 43
Y660
D
P
T
G
K
N
I
Y
L
H
D
I
W
P
S
Site 44
S682
E
E
E
H
V
I
L
S
M
F
K
A
L
K
D
Site 45
S700
M
G
N
K
R
W
N
S
L
E
A
P
D
S
V
Site 46
S706
N
S
L
E
A
P
D
S
V
L
F
P
W
D
L
Site 47
Y717
P
W
D
L
K
S
T
Y
I
R
C
P
S
F
F
Site 48
S722
S
T
Y
I
R
C
P
S
F
F
D
K
L
T
K
Site 49
T728
P
S
F
F
D
K
L
T
K
E
P
I
A
L
Q
Site 50
T751
L
Y
L
G
D
S
V
T
T
D
H
I
S
P
A
Site 51
S756
S
V
T
T
D
H
I
S
P
A
G
S
I
A
R
Site 52
S760
D
H
I
S
P
A
G
S
I
A
R
N
S
A
A
Site 53
S765
A
G
S
I
A
R
N
S
A
A
A
K
Y
L
T
Site 54
Y770
R
N
S
A
A
A
K
Y
L
T
N
R
G
L
T
Site 55
T772
S
A
A
A
K
Y
L
T
N
R
G
L
T
P
R
Site 56
T777
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
Site 57
S783
L
T
P
R
E
F
N
S
Y
G
A
R
R
G
N
Site 58
Y784
T
P
R
E
F
N
S
Y
G
A
R
R
G
N
D
Site 59
T816
I
G
K
P
A
P
K
T
I
H
F
P
S
G
Q
Site 60
S821
P
K
T
I
H
F
P
S
G
Q
T
L
D
V
F
Site 61
Y849
I
I
L
A
G
K
K
Y
G
S
G
N
S
R
D
Site 62
S901
L
P
G
E
N
A
D
S
L
G
L
S
G
R
E
Site 63
S905
N
A
D
S
L
G
L
S
G
R
E
T
F
S
L
Site 64
T909
L
G
L
S
G
R
E
T
F
S
L
T
F
P
E
Site 65
S911
L
S
G
R
E
T
F
S
L
T
F
P
E
E
L
Site 66
T913
G
R
E
T
F
S
L
T
F
P
E
E
L
S
P
Site 67
T923
E
E
L
S
P
G
I
T
L
N
I
Q
T
S
T
Site 68
Y949
D
D
V
E
I
T
L
Y
K
H
G
G
L
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation