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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFX2
Full Name:
DNA-binding protein RFX2
Alias:
Dna binding protein rfx2; Flj14226; HLA class II regulatory factor RFX2; Regulatory factor X 2; Regulatory factor x, 2 (influences hla class ii expression); Regulatory factor x2; Regulatory factor x2 isoform a; Regulatory factor x2 isoform b; Rfx2; Rfx2 protein; Trans-acting regulatory factor 2
Type:
Mass (Da):
79969
Number AA:
723
UniProt ID:
P48378
International Prot ID:
IPI00298182
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0030528
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
N
S
E
G
G
A
D
S
P
A
S
V
A
L
R
Site 2
S13
G
G
A
D
S
P
A
S
V
A
L
R
P
S
A
Site 3
S38
R
V
L
V
Q
A
A
S
S
N
P
K
G
A
Q
Site 4
S39
V
L
V
Q
A
A
S
S
N
P
K
G
A
Q
M
Site 5
S50
G
A
Q
M
Q
P
I
S
L
P
R
V
Q
Q
V
Site 6
Y68
V
Q
P
V
Q
H
V
Y
P
A
Q
V
Q
Y
V
Site 7
Y82
V
E
G
G
D
A
V
Y
T
N
G
A
I
R
T
Site 8
Y91
N
G
A
I
R
T
A
Y
T
Y
N
P
E
P
Q
Site 9
T92
G
A
I
R
T
A
Y
T
Y
N
P
E
P
Q
M
Site 10
Y93
A
I
R
T
A
Y
T
Y
N
P
E
P
Q
M
Y
Site 11
Y100
Y
N
P
E
P
Q
M
Y
A
P
S
S
T
A
S
Site 12
S103
E
P
Q
M
Y
A
P
S
S
T
A
S
Y
F
E
Site 13
S104
P
Q
M
Y
A
P
S
S
T
A
S
Y
F
E
A
Site 14
S107
Y
A
P
S
S
T
A
S
Y
F
E
A
P
G
G
Site 15
Y108
A
P
S
S
T
A
S
Y
F
E
A
P
G
G
A
Site 16
S159
L
I
H
G
G
M
D
S
T
R
H
S
L
A
H
Site 17
T160
I
H
G
G
M
D
S
T
R
H
S
L
A
H
T
Site 18
S163
G
M
D
S
T
R
H
S
L
A
H
T
S
R
S
Site 19
T167
T
R
H
S
L
A
H
T
S
R
S
S
P
A
T
Site 20
S168
R
H
S
L
A
H
T
S
R
S
S
P
A
T
L
Site 21
S170
S
L
A
H
T
S
R
S
S
P
A
T
L
E
M
Site 22
S171
L
A
H
T
S
R
S
S
P
A
T
L
E
M
A
Site 23
T174
T
S
R
S
S
P
A
T
L
E
M
A
I
E
N
Site 24
S185
A
I
E
N
L
Q
K
S
E
G
I
T
S
H
K
Site 25
T189
L
Q
K
S
E
G
I
T
S
H
K
S
G
L
L
Site 26
S190
Q
K
S
E
G
I
T
S
H
K
S
G
L
L
N
Site 27
S193
E
G
I
T
S
H
K
S
G
L
L
N
S
H
L
Site 28
S198
H
K
S
G
L
L
N
S
H
L
Q
W
L
L
D
Site 29
Y207
L
Q
W
L
L
D
N
Y
E
T
A
E
G
V
S
Site 30
S214
Y
E
T
A
E
G
V
S
L
P
R
S
S
L
Y
Site 31
S218
E
G
V
S
L
P
R
S
S
L
Y
N
H
Y
L
Site 32
S219
G
V
S
L
P
R
S
S
L
Y
N
H
Y
L
R
Site 33
Y221
S
L
P
R
S
S
L
Y
N
H
Y
L
R
H
C
Site 34
Y224
R
S
S
L
Y
N
H
Y
L
R
H
C
Q
E
H
Site 35
T254
S
V
F
M
G
L
R
T
R
R
L
G
T
R
G
Site 36
T259
L
R
T
R
R
L
G
T
R
G
N
S
K
Y
H
Site 37
S263
R
L
G
T
R
G
N
S
K
Y
H
Y
Y
G
I
Site 38
Y265
G
T
R
G
N
S
K
Y
H
Y
Y
G
I
R
L
Site 39
Y267
R
G
N
S
K
Y
H
Y
Y
G
I
R
L
K
P
Site 40
Y268
G
N
S
K
Y
H
Y
Y
G
I
R
L
K
P
D
Site 41
S276
G
I
R
L
K
P
D
S
P
L
N
R
L
Q
E
Site 42
Y287
R
L
Q
E
D
T
Q
Y
M
A
M
R
Q
Q
P
Site 43
Y301
P
M
H
Q
K
P
R
Y
R
P
A
Q
K
T
D
Site 44
T307
R
Y
R
P
A
Q
K
T
D
S
L
G
D
S
G
Site 45
S309
R
P
A
Q
K
T
D
S
L
G
D
S
G
S
H
Site 46
S313
K
T
D
S
L
G
D
S
G
S
H
S
G
L
H
Site 47
S315
D
S
L
G
D
S
G
S
H
S
G
L
H
S
T
Site 48
S317
L
G
D
S
G
S
H
S
G
L
H
S
T
P
E
Site 49
S321
G
S
H
S
G
L
H
S
T
P
E
Q
T
M
A
Site 50
T322
S
H
S
G
L
H
S
T
P
E
Q
T
M
A
V
Site 51
Y337
Q
S
Q
H
H
Q
Q
Y
I
D
V
S
H
V
F
Site 52
S402
L
W
L
S
F
W
N
S
K
A
S
S
S
D
G
Site 53
S405
S
F
W
N
S
K
A
S
S
S
D
G
P
T
S
Site 54
S406
F
W
N
S
K
A
S
S
S
D
G
P
T
S
L
Site 55
S407
W
N
S
K
A
S
S
S
D
G
P
T
S
L
P
Site 56
T411
A
S
S
S
D
G
P
T
S
L
P
A
S
D
E
Site 57
S412
S
S
S
D
G
P
T
S
L
P
A
S
D
E
D
Site 58
S416
G
P
T
S
L
P
A
S
D
E
D
P
E
G
A
Site 59
S468
D
V
L
R
P
V
P
S
T
L
T
Q
A
I
R
Site 60
T469
V
L
R
P
V
P
S
T
L
T
Q
A
I
R
N
Site 61
S480
A
I
R
N
F
A
K
S
L
E
G
W
L
T
N
Site 62
T486
K
S
L
E
G
W
L
T
N
A
M
S
D
F
P
Site 63
Y514
F
A
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Site 64
T515
A
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Q
Site 65
S516
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Q
A
Site 66
S532
R
A
V
L
Q
N
T
S
Q
I
N
Q
M
L
S
Site 67
S580
L
T
L
Q
Q
Q
S
S
L
D
Q
W
A
S
W
Site 68
S586
S
S
L
D
Q
W
A
S
W
L
D
S
V
V
T
Site 69
T593
S
W
L
D
S
V
V
T
Q
V
L
K
Q
H
A
Site 70
S602
V
L
K
Q
H
A
G
S
P
S
F
P
K
A
A
Site 71
S604
K
Q
H
A
G
S
P
S
F
P
K
A
A
R
Q
Site 72
Y651
L
Y
D
E
Y
M
F
Y
L
V
E
H
R
V
A
Site 73
S695
M
G
D
E
Q
R
G
S
E
A
G
P
D
A
R
Site 74
S703
E
A
G
P
D
A
R
S
L
G
E
P
L
V
K
Site 75
S714
P
L
V
K
R
E
R
S
D
P
N
H
S
L
Q
Site 76
S719
E
R
S
D
P
N
H
S
L
Q
G
I
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation