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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIP5K2A
Full Name:
Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
Alias:
1-phosphatidylinositol-4-phosphate 5-kinase; Diphosphoinositide kinase; EC 2.7.1.149; EC 2.7.1.68; Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; PI42A; PI52A; PIP5K2; PIP5KIIA; PIP5KIIalpha; PIP5KII-alpha; PIPK II-alpha; PtdIns(4)P-5-kinase B isoform
Type:
EC 2.7.1.68; EC 2.7.1.149; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid
Mass (Da):
46225
Number AA:
406
UniProt ID:
P48426
International Prot ID:
IPI00009688
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016308
GO:0016309
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
GO:0046488
GO:0016310
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
P
G
N
L
G
S
S
Site 2
S9
A
T
P
G
N
L
G
S
S
V
L
A
S
K
T
Site 3
S10
T
P
G
N
L
G
S
S
V
L
A
S
K
T
K
Site 4
S14
L
G
S
S
V
L
A
S
K
T
K
T
K
K
K
Site 5
T16
S
S
V
L
A
S
K
T
K
T
K
K
K
H
F
Site 6
T18
V
L
A
S
K
T
K
T
K
K
K
H
F
V
A
Site 7
Y93
S
H
F
K
F
K
E
Y
C
P
M
V
F
R
N
Site 8
S115
D
D
Q
D
F
Q
N
S
L
T
R
S
A
P
L
Site 9
T117
Q
D
F
Q
N
S
L
T
R
S
A
P
L
P
N
Site 10
S119
F
Q
N
S
L
T
R
S
A
P
L
P
N
D
S
Site 11
S126
S
A
P
L
P
N
D
S
Q
A
R
S
G
A
R
Site 12
S130
P
N
D
S
Q
A
R
S
G
A
R
F
H
T
S
Site 13
T136
R
S
G
A
R
F
H
T
S
Y
D
K
R
Y
I
Site 14
S137
S
G
A
R
F
H
T
S
Y
D
K
R
Y
I
I
Site 15
Y138
G
A
R
F
H
T
S
Y
D
K
R
Y
I
I
K
Site 16
Y142
H
T
S
Y
D
K
R
Y
I
I
K
T
I
T
S
Site 17
T146
D
K
R
Y
I
I
K
T
I
T
S
E
D
V
A
Site 18
Y162
M
H
N
I
L
K
K
Y
H
Q
Y
I
V
E
C
Site 19
Y192
N
V
D
G
V
E
I
Y
V
I
V
T
R
N
V
Site 20
S201
I
V
T
R
N
V
F
S
H
R
L
S
V
Y
R
Site 21
S205
N
V
F
S
H
R
L
S
V
Y
R
K
Y
D
L
Site 22
Y210
R
L
S
V
Y
R
K
Y
D
L
K
G
S
T
V
Site 23
S215
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
Site 24
T216
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
Site 25
S222
S
T
V
A
R
E
A
S
D
K
E
K
A
K
E
Site 26
Y246
I
N
E
G
Q
K
I
Y
I
D
D
N
N
K
K
Site 27
S304
D
G
E
E
E
G
E
S
D
G
T
H
P
V
G
Site 28
T307
E
E
G
E
S
D
G
T
H
P
V
G
T
P
P
Site 29
T312
D
G
T
H
P
V
G
T
P
P
D
S
P
G
N
Site 30
S316
P
V
G
T
P
P
D
S
P
G
N
T
L
N
S
Site 31
T320
P
P
D
S
P
G
N
T
L
N
S
S
P
P
L
Site 32
S323
S
P
G
N
T
L
N
S
S
P
P
L
A
P
G
Site 33
S324
P
G
N
T
L
N
S
S
P
P
L
A
P
G
E
Site 34
Y339
F
D
P
N
I
D
V
Y
G
I
K
C
H
E
N
Site 35
S347
G
I
K
C
H
E
N
S
P
R
K
E
V
Y
F
Site 36
Y353
N
S
P
R
K
E
V
Y
F
M
A
I
I
D
I
Site 37
T362
M
A
I
I
D
I
L
T
H
Y
D
A
K
K
K
Site 38
Y364
I
I
D
I
L
T
H
Y
D
A
K
K
K
A
A
Site 39
T376
K
A
A
H
A
A
K
T
V
K
H
G
A
G
A
Site 40
S386
H
G
A
G
A
E
I
S
T
V
N
P
E
Q
Y
Site 41
T387
G
A
G
A
E
I
S
T
V
N
P
E
Q
Y
S
Site 42
Y393
S
T
V
N
P
E
Q
Y
S
K
R
F
L
D
F
Site 43
S394
T
V
N
P
E
Q
Y
S
K
R
F
L
D
F
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation