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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP3CC
Full Name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Alias:
Calcineurin A gamma; Calcineurin, testis-specific catalytic subunit; CALNA3; CAM- PRP catalytic subunit; EC 3.1.3.16; P2BC; PP2BC; PP2B-gamma
Type:
Cytosol protein
Mass (Da):
57073
Number AA:
502
UniProt ID:
P48454
International Prot ID:
IPI00305491
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0005506
GO:0004721
PhosphoSite+
KinaseNET
Biological Process:
GO:0008633
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
G
R
R
F
H
L
S
T
T
D
R
V
I
K
Site 2
T10
G
R
R
F
H
L
S
T
T
D
R
V
I
K
A
Site 3
T11
R
R
F
H
L
S
T
T
D
R
V
I
K
A
V
Site 4
T23
K
A
V
P
F
P
P
T
Q
R
L
T
F
K
E
Site 5
T27
F
P
P
T
Q
R
L
T
F
K
E
V
F
E
N
Site 6
T73
A
I
L
R
Q
E
K
T
M
I
E
V
D
A
P
Site 7
S103
K
L
F
E
V
G
G
S
P
S
N
T
R
Y
L
Site 8
S105
F
E
V
G
G
S
P
S
N
T
R
Y
L
F
L
Site 9
T107
V
G
G
S
P
S
N
T
R
Y
L
F
L
G
D
Site 10
Y109
G
S
P
S
N
T
R
Y
L
F
L
G
D
Y
V
Site 11
Y115
R
Y
L
F
L
G
D
Y
V
D
R
G
Y
F
S
Site 12
T139
L
K
I
N
H
P
K
T
L
F
L
L
R
G
N
Site 13
Y155
E
C
R
H
L
T
D
Y
F
T
F
K
Q
E
C
Site 14
Y166
K
Q
E
C
R
I
K
Y
S
E
Q
V
Y
D
A
Site 15
Y171
I
K
Y
S
E
Q
V
Y
D
A
C
M
E
T
F
Site 16
T203
G
G
M
S
P
E
I
T
S
L
D
D
I
R
K
Site 17
T215
I
R
K
L
D
R
F
T
E
P
P
A
F
G
P
Site 18
S229
P
V
C
D
L
L
W
S
D
P
S
E
D
Y
G
Site 19
S232
D
L
L
W
S
D
P
S
E
D
Y
G
N
E
K
Site 20
Y235
W
S
D
P
S
E
D
Y
G
N
E
K
T
L
E
Site 21
T240
E
D
Y
G
N
E
K
T
L
E
H
Y
T
H
N
Site 22
Y254
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Site 23
Y284
H
E
A
Q
D
A
G
Y
R
M
Y
R
K
S
Q
Site 24
Y287
Q
D
A
G
Y
R
M
Y
R
K
S
Q
A
T
G
Site 25
S290
G
Y
R
M
Y
R
K
S
Q
A
T
G
F
P
S
Site 26
T293
M
Y
R
K
S
Q
A
T
G
F
P
S
L
I
T
Site 27
Y307
T
I
F
S
A
P
N
Y
L
D
V
Y
N
N
K
Site 28
Y311
A
P
N
Y
L
D
V
Y
N
N
K
A
A
V
L
Site 29
Y320
N
K
A
A
V
L
K
Y
E
N
N
V
M
N
I
Site 30
S382
S
D
D
E
A
E
G
S
T
T
V
R
K
E
I
Site 31
T384
D
E
A
E
G
S
T
T
V
R
K
E
I
I
R
Site 32
S405
G
K
M
A
R
V
F
S
I
L
R
Q
E
S
E
Site 33
S411
F
S
I
L
R
Q
E
S
E
S
V
L
T
L
K
Site 34
T416
Q
E
S
E
S
V
L
T
L
K
G
L
T
P
T
Site 35
S456
R
E
A
I
R
G
F
S
L
Q
H
K
I
R
S
Site 36
S463
S
L
Q
H
K
I
R
S
F
E
E
A
R
G
L
Site 37
S483
R
M
P
P
R
K
D
S
I
H
A
G
G
P
M
Site 38
S492
H
A
G
G
P
M
K
S
V
T
S
A
H
S
H
Site 39
T494
G
G
P
M
K
S
V
T
S
A
H
S
H
A
A
Site 40
S495
G
P
M
K
S
V
T
S
A
H
S
H
A
A
H
Site 41
S498
K
S
V
T
S
A
H
S
H
A
A
H
R
S
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation