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Updated November 2019
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Protein Info
Short Name:
RIP140
Full Name:
Nuclear receptor-interacting protein 1
Alias:
NRIP1; Nuclear factor RIP140; Nuclear receptor interacting protein 1; Receptor interacting protein 140
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
126942
Number AA:
1158
UniProt ID:
P48552
International Prot ID:
IPI00010196
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0030331
GO:0035259
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0000122
GO:0045944
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
T
H
G
E
E
L
G
S
D
V
H
Q
D
S
I
Site 2
S15
G
S
D
V
H
Q
D
S
I
V
L
T
Y
L
E
Site 3
S41
G
T
A
V
D
K
K
S
A
G
H
N
E
E
D
Site 4
S56
Q
N
F
N
I
S
G
S
A
F
P
T
C
Q
S
Site 5
T60
I
S
G
S
A
F
P
T
C
Q
S
N
G
P
V
Site 6
T70
S
N
G
P
V
L
N
T
H
T
Y
Q
G
S
G
Site 7
T72
G
P
V
L
N
T
H
T
Y
Q
G
S
G
M
L
Site 8
Y73
P
V
L
N
T
H
T
Y
Q
G
S
G
M
L
H
Site 9
S90
K
A
R
L
L
Q
S
S
E
D
W
N
A
A
K
Site 10
S102
A
A
K
R
K
R
L
S
D
S
I
M
N
L
N
Site 11
S104
K
R
K
R
L
S
D
S
I
M
N
L
N
V
K
Site 12
S122
L
L
A
G
M
V
D
S
V
P
K
G
K
Q
D
Site 13
S130
V
P
K
G
K
Q
D
S
T
L
L
A
S
L
L
Site 14
T131
P
K
G
K
Q
D
S
T
L
L
A
S
L
L
Q
Site 15
T146
S
F
S
S
R
L
Q
T
V
A
L
S
Q
Q
I
Site 16
S150
R
L
Q
T
V
A
L
S
Q
Q
I
R
Q
S
L
Site 17
S156
L
S
Q
Q
I
R
Q
S
L
K
E
Q
G
Y
A
Site 18
S165
K
E
Q
G
Y
A
L
S
H
D
S
L
K
V
E
Site 19
S168
G
Y
A
L
S
H
D
S
L
K
V
E
K
D
L
Site 20
Y178
V
E
K
D
L
R
C
Y
G
V
A
S
S
H
L
Site 21
S183
R
C
Y
G
V
A
S
S
H
L
K
T
L
L
K
Site 22
T187
V
A
S
S
H
L
K
T
L
L
K
K
S
K
V
Site 23
S192
L
K
T
L
L
K
K
S
K
V
K
D
Q
K
P
Site 24
T201
V
K
D
Q
K
P
D
T
N
L
P
D
V
T
K
Site 25
T207
D
T
N
L
P
D
V
T
K
N
L
I
R
D
R
Site 26
S218
I
R
D
R
F
A
E
S
P
H
H
V
G
Q
S
Site 27
S231
Q
S
G
T
K
V
M
S
E
P
L
S
C
A
A
Site 28
S245
A
R
L
Q
A
V
A
S
M
V
E
K
R
A
S
Site 29
S252
S
M
V
E
K
R
A
S
P
A
T
S
P
K
P
Site 30
T255
E
K
R
A
S
P
A
T
S
P
K
P
S
V
A
Site 31
S256
K
R
A
S
P
A
T
S
P
K
P
S
V
A
C
Site 32
S260
P
A
T
S
P
K
P
S
V
A
C
S
Q
L
A
Site 33
Y279
S
E
A
H
L
Q
Q
Y
S
R
E
H
A
L
K
Site 34
T287
S
R
E
H
A
L
K
T
Q
N
A
N
Q
A
A
Site 35
S314
N
G
Q
K
D
V
G
S
Y
Q
L
P
K
G
M
Site 36
Y315
G
Q
K
D
V
G
S
Y
Q
L
P
K
G
M
S
Site 37
S332
L
N
G
Q
A
R
T
S
S
S
K
L
M
A
S
Site 38
S333
N
G
Q
A
R
T
S
S
S
K
L
M
A
S
K
Site 39
S334
G
Q
A
R
T
S
S
S
K
L
M
A
S
K
S
Site 40
S339
S
S
S
K
L
M
A
S
K
S
S
A
T
V
F
Site 41
S341
S
K
L
M
A
S
K
S
S
A
T
V
F
Q
N
Site 42
S355
N
P
M
G
I
I
P
S
S
P
K
N
A
G
Y
Site 43
S356
P
M
G
I
I
P
S
S
P
K
N
A
G
Y
K
Site 44
Y362
S
S
P
K
N
A
G
Y
K
N
S
L
E
R
N
Site 45
S365
K
N
A
G
Y
K
N
S
L
E
R
N
N
I
K
Site 46
S378
I
K
Q
A
A
N
N
S
L
L
L
H
L
L
K
Site 47
T388
L
H
L
L
K
S
Q
T
I
P
K
P
M
N
G
Site 48
S397
P
K
P
M
N
G
H
S
H
S
E
R
G
S
I
Site 49
S399
P
M
N
G
H
S
H
S
E
R
G
S
I
F
E
Site 50
S403
H
S
H
S
E
R
G
S
I
F
E
E
S
S
T
Site 51
S408
R
G
S
I
F
E
E
S
S
T
P
T
T
I
D
Site 52
T410
S
I
F
E
E
S
S
T
P
T
T
I
D
E
Y
Site 53
T412
F
E
E
S
S
T
P
T
T
I
D
E
Y
S
D
Site 54
T413
E
E
S
S
T
P
T
T
I
D
E
Y
S
D
N
Site 55
Y417
T
P
T
T
I
D
E
Y
S
D
N
N
P
S
F
Site 56
S418
P
T
T
I
D
E
Y
S
D
N
N
P
S
F
T
Site 57
S423
E
Y
S
D
N
N
P
S
F
T
D
D
S
S
G
Site 58
T425
S
D
N
N
P
S
F
T
D
D
S
S
G
D
E
Site 59
S428
N
P
S
F
T
D
D
S
S
G
D
E
S
S
Y
Site 60
S429
P
S
F
T
D
D
S
S
G
D
E
S
S
Y
S
Site 61
S433
D
D
S
S
G
D
E
S
S
Y
S
N
C
V
P
Site 62
S434
D
S
S
G
D
E
S
S
Y
S
N
C
V
P
I
Site 63
Y435
S
S
G
D
E
S
S
Y
S
N
C
V
P
I
D
Site 64
S436
S
G
D
E
S
S
Y
S
N
C
V
P
I
D
L
Site 65
S452
C
K
H
R
T
E
K
S
E
S
D
Q
P
V
S
Site 66
S454
H
R
T
E
K
S
E
S
D
Q
P
V
S
L
D
Site 67
S459
S
E
S
D
Q
P
V
S
L
D
N
F
T
Q
S
Site 68
T464
P
V
S
L
D
N
F
T
Q
S
L
L
N
T
W
Site 69
S466
S
L
D
N
F
T
Q
S
L
L
N
T
W
D
P
Site 70
T470
F
T
Q
S
L
L
N
T
W
D
P
K
V
P
D
Site 71
T486
D
I
K
E
D
Q
D
T
S
K
N
S
K
L
N
Site 72
S487
I
K
E
D
Q
D
T
S
K
N
S
K
L
N
S
Site 73
S490
D
Q
D
T
S
K
N
S
K
L
N
S
H
Q
K
Site 74
S494
S
K
N
S
K
L
N
S
H
Q
K
V
T
L
L
Site 75
S518
E
N
V
E
K
N
T
S
P
Q
G
V
H
N
D
Site 76
T531
N
D
V
S
K
F
N
T
Q
N
Y
A
R
T
S
Site 77
Y534
S
K
F
N
T
Q
N
Y
A
R
T
S
V
I
E
Site 78
S538
T
Q
N
Y
A
R
T
S
V
I
E
S
P
S
T
Site 79
S542
A
R
T
S
V
I
E
S
P
S
T
N
R
T
T
Site 80
T545
S
V
I
E
S
P
S
T
N
R
T
T
P
V
S
Site 81
T548
E
S
P
S
T
N
R
T
T
P
V
S
T
P
P
Site 82
T549
S
P
S
T
N
R
T
T
P
V
S
T
P
P
L
Site 83
S552
T
N
R
T
T
P
V
S
T
P
P
L
L
T
S
Site 84
T553
N
R
T
T
P
V
S
T
P
P
L
L
T
S
S
Site 85
T558
V
S
T
P
P
L
L
T
S
S
K
A
G
S
P
Site 86
S559
S
T
P
P
L
L
T
S
S
K
A
G
S
P
I
Site 87
S560
T
P
P
L
L
T
S
S
K
A
G
S
P
I
N
Site 88
S564
L
T
S
S
K
A
G
S
P
I
N
L
S
Q
H
Site 89
S572
P
I
N
L
S
Q
H
S
L
V
I
K
W
N
S
Site 90
Y582
I
K
W
N
S
P
P
Y
V
C
S
T
Q
S
E
Site 91
S585
N
S
P
P
Y
V
C
S
T
Q
S
E
K
L
T
Site 92
T586
S
P
P
Y
V
C
S
T
Q
S
E
K
L
T
N
Site 93
T592
S
T
Q
S
E
K
L
T
N
T
A
S
N
H
S
Site 94
T594
Q
S
E
K
L
T
N
T
A
S
N
H
S
M
D
Site 95
T603
S
N
H
S
M
D
L
T
K
S
K
D
P
P
G
Site 96
S605
H
S
M
D
L
T
K
S
K
D
P
P
G
E
K
Site 97
S622
Q
N
E
G
A
Q
N
S
A
T
F
S
A
S
K
Site 98
T624
E
G
A
Q
N
S
A
T
F
S
A
S
K
L
L
Site 99
S626
A
Q
N
S
A
T
F
S
A
S
K
L
L
Q
N
Site 100
S642
A
Q
C
G
M
Q
S
S
M
S
V
E
E
Q
R
Site 101
S644
C
G
M
Q
S
S
M
S
V
E
E
Q
R
P
S
Site 102
S651
S
V
E
E
Q
R
P
S
K
Q
L
L
T
G
N
Site 103
T659
K
Q
L
L
T
G
N
T
D
K
P
I
G
M
I
Site 104
S671
G
M
I
D
R
L
N
S
P
L
L
S
N
K
T
Site 105
S675
R
L
N
S
P
L
L
S
N
K
T
N
A
V
E
Site 106
T678
S
P
L
L
S
N
K
T
N
A
V
E
E
N
K
Site 107
S689
E
E
N
K
A
F
S
S
Q
P
T
G
P
E
P
Site 108
T692
K
A
F
S
S
Q
P
T
G
P
E
P
G
L
S
Site 109
S699
T
G
P
E
P
G
L
S
G
S
E
I
E
N
L
Site 110
S701
P
E
P
G
L
S
G
S
E
I
E
N
L
L
E
Site 111
S725
G
N
P
N
K
G
K
S
E
K
K
E
K
T
P
Site 112
T731
K
S
E
K
K
E
K
T
P
L
R
D
E
S
T
Site 113
S737
K
T
P
L
R
D
E
S
T
Q
E
H
S
E
R
Site 114
T738
T
P
L
R
D
E
S
T
Q
E
H
S
E
R
A
Site 115
S742
D
E
S
T
Q
E
H
S
E
R
A
L
S
E
Q
Site 116
S747
E
H
S
E
R
A
L
S
E
Q
I
L
M
V
K
Site 117
S757
I
L
M
V
K
I
K
S
E
P
C
D
D
L
Q
Site 118
T768
D
D
L
Q
I
P
N
T
N
V
H
L
S
H
D
Site 119
S773
P
N
T
N
V
H
L
S
H
D
A
K
S
A
P
Site 120
S778
H
L
S
H
D
A
K
S
A
P
F
L
G
M
A
Site 121
S798
S
A
P
A
L
P
V
S
E
D
F
K
S
E
P
Site 122
S803
P
V
S
E
D
F
K
S
E
P
V
S
P
Q
D
Site 123
S807
D
F
K
S
E
P
V
S
P
Q
D
F
S
F
S
Site 124
S812
P
V
S
P
Q
D
F
S
F
S
K
N
G
L
L
Site 125
S814
S
P
Q
D
F
S
F
S
K
N
G
L
L
S
R
Site 126
S829
L
L
R
Q
N
Q
D
S
Y
L
A
D
D
S
D
Site 127
Y830
L
R
Q
N
Q
D
S
Y
L
A
D
D
S
D
R
Site 128
S835
D
S
Y
L
A
D
D
S
D
R
S
H
R
N
N
Site 129
S838
L
A
D
D
S
D
R
S
H
R
N
N
E
M
A
Site 130
Y862
V
P
K
K
R
K
L
Y
T
E
P
L
E
N
P
Site 131
Y911
R
N
D
L
E
F
K
Y
P
A
G
H
G
S
A
Site 132
S917
K
Y
P
A
G
H
G
S
A
S
E
S
E
H
R
Site 133
S919
P
A
G
H
G
S
A
S
E
S
E
H
R
S
W
Site 134
S921
G
H
G
S
A
S
E
S
E
H
R
S
W
A
R
Site 135
S925
A
S
E
S
E
H
R
S
W
A
R
E
S
K
S
Site 136
S930
H
R
S
W
A
R
E
S
K
S
F
N
V
L
K
Site 137
S932
S
W
A
R
E
S
K
S
F
N
V
L
K
Q
L
Site 138
S950
E
N
C
V
R
D
L
S
P
H
R
S
N
S
V
Site 139
S954
R
D
L
S
P
H
R
S
N
S
V
A
D
S
K
Site 140
S956
L
S
P
H
R
S
N
S
V
A
D
S
K
K
K
Site 141
S960
R
S
N
S
V
A
D
S
K
K
K
G
H
K
N
Site 142
S972
H
K
N
N
V
T
N
S
K
P
E
F
S
I
S
Site 143
S977
T
N
S
K
P
E
F
S
I
S
S
L
N
G
L
Site 144
S979
S
K
P
E
F
S
I
S
S
L
N
G
L
M
Y
Site 145
S980
K
P
E
F
S
I
S
S
L
N
G
L
M
Y
S
Site 146
Y986
S
S
L
N
G
L
M
Y
S
S
T
Q
P
S
S
Site 147
S987
S
L
N
G
L
M
Y
S
S
T
Q
P
S
S
C
Site 148
S988
L
N
G
L
M
Y
S
S
T
Q
P
S
S
C
M
Site 149
T989
N
G
L
M
Y
S
S
T
Q
P
S
S
C
M
D
Site 150
S992
M
Y
S
S
T
Q
P
S
S
C
M
D
N
R
T
Site 151
S993
Y
S
S
T
Q
P
S
S
C
M
D
N
R
T
F
Site 152
T999
S
S
C
M
D
N
R
T
F
S
Y
P
G
V
V
Site 153
S1001
C
M
D
N
R
T
F
S
Y
P
G
V
V
K
T
Site 154
T1008
S
Y
P
G
V
V
K
T
P
V
S
P
T
F
P
Site 155
S1011
G
V
V
K
T
P
V
S
P
T
F
P
E
H
L
Site 156
T1013
V
K
T
P
V
S
P
T
F
P
E
H
L
G
C
Site 157
S1023
E
H
L
G
C
A
G
S
R
P
E
S
G
L
L
Site 158
S1027
C
A
G
S
R
P
E
S
G
L
L
N
G
C
S
Site 159
S1034
S
G
L
L
N
G
C
S
M
P
S
E
K
G
P
Site 160
Y1054
T
D
A
E
K
N
E
Y
E
K
D
S
P
R
L
Site 161
S1058
K
N
E
Y
E
K
D
S
P
R
L
T
K
T
N
Site 162
T1062
E
K
D
S
P
R
L
T
K
T
N
P
I
L
Y
Site 163
T1064
D
S
P
R
L
T
K
T
N
P
I
L
Y
Y
M
Site 164
Y1069
T
K
T
N
P
I
L
Y
Y
M
L
Q
K
G
G
Site 165
Y1070
K
T
N
P
I
L
Y
Y
M
L
Q
K
G
G
N
Site 166
T1084
N
S
V
T
S
R
E
T
Q
D
K
D
I
W
R
Site 167
S1094
K
D
I
W
R
E
A
S
S
A
E
S
V
S
Q
Site 168
S1095
D
I
W
R
E
A
S
S
A
E
S
V
S
Q
V
Site 169
S1098
R
E
A
S
S
A
E
S
V
S
Q
V
T
A
K
Site 170
S1100
A
S
S
A
E
S
V
S
Q
V
T
A
K
E
E
Site 171
T1111
A
K
E
E
L
L
P
T
A
E
T
K
A
S
F
Site 172
S1117
P
T
A
E
T
K
A
S
F
F
N
L
R
S
P
Site 173
S1123
A
S
F
F
N
L
R
S
P
Y
N
S
H
M
G
Site 174
Y1125
F
F
N
L
R
S
P
Y
N
S
H
M
G
N
N
Site 175
S1127
N
L
R
S
P
Y
N
S
H
M
G
N
N
A
S
Site 176
S1134
S
H
M
G
N
N
A
S
R
P
H
S
A
N
G
Site 177
S1138
N
N
A
S
R
P
H
S
A
N
G
E
V
Y
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation